Hs03621041_cn

• Gene Symbol: YWHAG
• Assay Reference Genome Location: Chr.7:76347775 on build GRCh38
• Cytoband: 7q11.23

Target Gene Details

• Entrez Gene ID: 7532
• Gene Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
• Gene Aliases: 14-3-3GAMMA, PPP1R170
• Location: Chr.7:76326791-76359025 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
YWHAG	NM_012479.3			NP_036611.2
	AB024334.1			BAA85184.1
	AF142498.1			AAD48408.1
	AK024230.1
	AK293505.1
	AK295029.1
	BC020963.2			AAH20963.1
	CR541904.1			CAG46702.1
	CR541925.1			CAG46723.1
	DC343104.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2422494	Chr.7:76286900 - 76984449 on Build GRCh38	Duplication	LOC105375355 SRRM3 LOC100133091 ZP3 DTX2P1-UPK3BP1-PMS2P11 POMZP3 HSPB1 SSC4D SPDYE16 YWHAG FDPSP2 DTX2
nsv428174	Chr.7:76305019 - 77220062 on Build GRCh38	Gain	ZP3 DTX2P1-UPK3BP1-PMS2P11 POMZP3 SPDYE17 PMS2P9 SSC4D SPDYE16 YWHAG FDPSP2 LOC105375355 SPDYE18 LOC100133091 FGL2 CCDC146 DTX2
nsv528969	Chr.7:75074053 - 76920728 on Build GRCh38	Gain	STAG3L1 ZP3 PMS2P10 SSC4D SPDYE16 YWHAG STYXL1 SPDYE5 CCL26 LOC107986711 LOC100133091 LOC541473 PMS2P3 HSPB1 RHBDD2 LOC441259 GTF2IP1 TMEM120A POM121C TRIM73 HIP1 PMS2P2 POMZP3 GTF2IRD2B MIR4651 FDPSP2 LOC105375355 SRRM3 SNORA14A GTF2IP7 POR NSUN5P1 NCF1C CCL24 MDH2 DTX2
nsv1028665	Chr.7:76336044 - 76445651 on Build GRCh38	Gain	ZP3 SSC4D YWHAG
dgv120n16	Chr.7:75440769 - 76641919 on Build GRCh38	Deletion	ZP3 SSC4D SPDYE16 YWHAG STYXL1 SPDYE5 CCL26 LOC107986711 LOC100133091 PMS2P3 HSPB1 RHBDD2 TMEM120A POM121C HIP1 POMZP3 MIR4651 FDPSP2 LOC105375355 SRRM3 SNORA14A GTF2IP7 POR CCL24 MDH2 DTX2

More Information

Additional Information:

For this assay, SNP(s) [rs73359657] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

G2/M transition of mitotic cell cycle
negative regulation of protein kinase activity
protein targeting
regulation of signal transduction
cellular response to insulin stimulus
regulation of neuron differentiation
regulation of synaptic plasticity
membrane organization
negative regulation of protein serine/threonine kinase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Function(s)

protein kinase C binding
insulin-like growth factor receptor binding
protein binding
protein kinase C inhibitor activity
protein domain specific binding
receptor tyrosine kinase binding
poly(A) RNA binding