Hs03638921_cn

• Gene Symbol: FIS1
• Assay Reference Genome Location: Chr.7:101243247 on build GRCh38
• Cytoband: 7q22.1

Target Gene Details

• Entrez Gene ID: 51024
• Gene Name: fission, mitochondrial 1
• Gene Aliases: CGI-135, TTC11
• Location: Chr.7:101239612-101245090 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FIS1	NM_016068.2			NP_057152.2
	AF151893.1			AAD34130.1
	AK310968.1
	AK311665.1
	BC003540.1			AAH03540.1
	BC009428.1			AAH09428.1
	BI836529.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv5875	Chr.7:101227053 - 101259693 on Build GRCh38	Insertion	CLDN15 FIS1
nsv831077	Chr.7:101230928 - 101440649 on Build GRCh38	Loss	LOC101927721 CLDN15 COL26A1 IFT22 FIS1 LOC101927746
esv2422376	Chr.7:101100204 - 101373190 on Build GRCh38	Duplication	NAT16 MOGAT3 CLDN15 AP1S1 MIR4653 ZNHIT1 LOC101927721 COL26A1 SERPINE1 VGF IFT22 PLOD3 FIS1 LOC101927746
esv2422326	Chr.7:101190168 - 101356850 on Build GRCh38	Duplication	MOGAT3 LOC101927721 CLDN15 IFT22 PLOD3 FIS1 LOC101927746 ZNHIT1
nsv1030604	Chr.7:101074451 - 101580185 on Build GRCh38	Gain	NAT16 MOGAT3 CLDN15 LINC01007 AP1S1 TRIM56 MIR4653 ZNHIT1 LOC101927721 COL26A1 SERPINE1 VGF IFT22 PLOD3 FIS1 LOC101927746
esv2734888	Chr.7:99975623 - 101290285 on Build GRCh38	Deletion	PMS2P1 TRIM56 ZKSCAN1 ZCWPW1 UFSP1 MIR93 POP7 STAG3 STAG3L5P TAF6 GPC2 AZGP1P1 C7orf43 LAMTOR4 CNPY4 ZSCAN21 NAT16 CLDN15 SAP25 PILRA GATS PCOLCE-AS1 MEPCE MIR6840 ZNHIT1 SPDYE3 SRRT LOC105375429 NYAP1 PPP1R35 PCOLCE GNB2 ZNF3 MIR106B MOSPD3 LRCH4 MIR6875 TRIP6 AP1S1 MUC3A AGFG2 PVRIG2P SLC12A9 MIR4653 TSC22D4 MIR4658 ACTL6B MUC12 MBLAC1 ZAN PVRIG SERPINE1 VGF AZGP1 PLOD3 FIS1 MUC17 C7orf61 FBXO24 PILRB MOGAT3 GIGYF1 MIR25 COPS6 ZASP ACHE EPHB4 STAG3L5P-PVRIG2P-PILRB TFR2 MCM7 LOC102724094 GAL3ST4 AP4M1 EPO
esv2752134	Chr.7:101156850 - 101498586 on Build GRCh38	Gain	NAT16 MOGAT3 CLDN15 AP1S1 MIR4653 ZNHIT1 LOC101927721 COL26A1 VGF IFT22 PLOD3 FIS1 LOC101927746
nsv607978	Chr.7:101217932 - 101328323 on Build GRCh38	Loss	LOC101927721 CLDN15 IFT22 FIS1 LOC101927746 ZNHIT1
nsv831075	Chr.7:101049016 - 101273737 on Build GRCh38	Loss	NAT16 MOGAT3 CLDN15 AP1S1 SERPINE1 VGF PLOD3 TRIM56 MIR4653 FIS1 MUC17 ZNHIT1
nsv607974	Chr.7:101149529 - 101328323 on Build GRCh38	Loss	NAT16 MOGAT3 LOC101927721 CLDN15 AP1S1 VGF IFT22 PLOD3 MIR4653 FIS1 LOC101927746 ZNHIT1
esv3614318	Chr.7:101206795 - 101265542 on Build GRCh38	Loss	CLDN15 PLOD3 FIS1 ZNHIT1
esv3614324	Chr.7:101231569 - 101248238 on Build GRCh38	Gain	CLDN15 FIS1
nsv831076	Chr.7:101185566 - 101368393 on Build GRCh38	Loss	MOGAT3 LOC101927721 CLDN15 COL26A1 IFT22 PLOD3 FIS1 LOC101927746 ZNHIT1

More Information

Additional Information:

For this assay, SNP(s) [rs75628363] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

mitochondrial fission
mitophagy
release of cytochrome c from mitochondria
protein targeting to mitochondrion
positive regulation of cytosolic calcium ion concentration
mitochondrial fusion
regulation of mitochondrion organization
peroxisome fission
negative regulation of endoplasmic reticulum calcium ion concentration
calcium-mediated signaling using intracellular calcium source
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial fragmentation involved in apoptotic process
protein homooligomerization
positive regulation of mitochondrial calcium ion concentration
mitochondrion morphogenesis
positive regulation of mitochondrial fission
positive regulation of protein targeting to membrane
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

receptor binding
protein binding