Hs03638921_cn

• Gene Symbol: FIS1
• Assay Reference Genome Location: Chr.7:101243247 on build GRCh38
• Cytoband: 7q22.1

Target Gene Details

• Entrez Gene ID: 51024
• Gene Name: fission, mitochondrial 1
• Gene Aliases: CGI-135, TTC11
• Location: Chr.7:101239612-101245090 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FIS1	NM_016068.2			NP_057152.2
	AF151893.1			AAD34130.1
	AK310968.1
	AK311665.1
	BC003540.1			AAH03540.1
	BC009428.1			AAH09428.1
	BI836529.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv5875	Chr.7:101227053 - 101259693 on Build GRCh38	Insertion	FIS1 CLDN15
nsv831077	Chr.7:101230928 - 101440649 on Build GRCh38	Loss	LOC101927746 LOC101927721 COL26A1 FIS1 CLDN15 IFT22
esv2422376	Chr.7:101100204 - 101373190 on Build GRCh38	Duplication	ZNHIT1 COL26A1 FIS1 NAT16 MOGAT3 CLDN15 IFT22 LOC101927746 LOC101927721 MIR4653 SERPINE1 AP1S1 PLOD3 VGF
esv2422326	Chr.7:101190168 - 101356850 on Build GRCh38	Duplication	LOC101927746 ZNHIT1 LOC101927721 FIS1 MOGAT3 CLDN15 IFT22 PLOD3
nsv1030604	Chr.7:101074451 - 101580185 on Build GRCh38	Gain	ZNHIT1 COL26A1 FIS1 NAT16 MOGAT3 CLDN15 TRIM56 IFT22 LINC01007 LOC101927746 LOC101927721 MIR4653 SERPINE1 AP1S1 PLOD3 VGF
nsv607978	Chr.7:101217932 - 101328323 on Build GRCh38	Loss	LOC101927746 ZNHIT1 LOC101927721 FIS1 CLDN15 IFT22
esv2752134	Chr.7:101156850 - 101498586 on Build GRCh38	Gain	ZNHIT1 COL26A1 FIS1 NAT16 MOGAT3 CLDN15 IFT22 LOC101927746 LOC101927721 MIR4653 AP1S1 PLOD3 VGF
esv2734888	Chr.7:99975623 - 101290285 on Build GRCh38	Deletion	PVRIG2P PVRIG ZCWPW1 LOC102724094 FBXO24 MUC3A ACHE C7orf43 TRIM56 LAMTOR4 STAG3 MIR4658 ZASP MUC17 LOC105375429 MBLAC1 NYAP1 AP1S1 POP7 MCM7 UFSP1 VGF SPDYE3 MIR106B PILRA AZGP1P1 NAT16 ZKSCAN1 GIGYF1 CNPY4 COPS6 PPP1R35 TRIP6 GAL3ST4 PLOD3 PCOLCE-AS1 AP4M1 ZNHIT1 ZSCAN21 ACTL6B MEPCE FIS1 AZGP1 MIR6875 PILRB CLDN15 EPO SLC12A9 MIR6840 STAG3L5P-PVRIG2P-PILRB PMS2P1 PCOLCE TSC22D4 SRRT STAG3L5P SAP25 GPC2 MOSPD3 ZAN MIR25 C7orf61 MOGAT3 MIR93 TAF6 AGFG2 MIR4653 MUC12 LRCH4 TFR2 SERPINE1 ZNF3 GNB2 GATS EPHB4
nsv831075	Chr.7:101049016 - 101273737 on Build GRCh38	Loss	ZNHIT1 MUC17 MIR4653 FIS1 NAT16 SERPINE1 MOGAT3 CLDN15 AP1S1 TRIM56 PLOD3 VGF
nsv607974	Chr.7:101149529 - 101328323 on Build GRCh38	Loss	LOC101927746 ZNHIT1 LOC101927721 MIR4653 FIS1 NAT16 MOGAT3 CLDN15 AP1S1 IFT22 PLOD3 VGF
esv3614323	Chr.7:101231569 - 101248238 on Build GRCh38	Loss	FIS1 CLDN15
esv3614319	Chr.7:101206795 - 101265542 on Build GRCh38	Gain	ZNHIT1 FIS1 CLDN15 PLOD3
nsv831076	Chr.7:101185566 - 101368393 on Build GRCh38	Loss	LOC101927746 ZNHIT1 LOC101927721 COL26A1 FIS1 MOGAT3 CLDN15 IFT22 PLOD3

More Information

Additional Information:

For this assay, SNP(s) [rs75628363] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

mitochondrial fission
mitophagy
release of cytochrome c from mitochondria
protein targeting to mitochondrion
positive regulation of cytosolic calcium ion concentration
mitochondrial fusion
regulation of mitochondrion organization
peroxisome fission
negative regulation of endoplasmic reticulum calcium ion concentration
calcium-mediated signaling using intracellular calcium source
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial fragmentation involved in apoptotic process
protein homooligomerization
positive regulation of mitochondrial calcium ion concentration
mitochondrion morphogenesis
positive regulation of mitochondrial fission
positive regulation of protein targeting to membrane
positive regulation of intrinsic apoptotic signaling pathway

Function(s)

receptor binding
protein binding