Hs03645732_cn

• Gene Symbol: YWHAG
• Assay Reference Genome Location: Chr.7:76355026 on build GRCh38
• Cytoband: 7q11.23

Target Gene Details

• Entrez Gene ID: 7532
• Gene Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
• Gene Aliases: 14-3-3GAMMA, PPP1R170
• Location: Chr.7:76326791-76359025 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
YWHAG	NM_012479.3			NP_036611.2
	AB024334.1			BAA85184.1
	AF142498.1			AAD48408.1
	AK024230.1
	AK293505.1
	AK295029.1
	BC020963.2			AAH20963.1
	CR541904.1			CAG46702.1
	CR541925.1			CAG46723.1
	DC343104.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2422494	Chr.7:76286900 - 76984449 on Build GRCh38	Duplication	HSPB1 ZP3 POMZP3 DTX2P1-UPK3BP1-PMS2P11 SSC4D SPDYE16 YWHAG LOC105375355 SRRM3 FDPSP2 DTX2 LOC100133091
nsv528969	Chr.7:75074053 - 76920728 on Build GRCh38	Gain	POM121C GTF2IP7 SSC4D LOC105375355 STAG3L1 DTX2 LOC541473 HSPB1 POR PMS2P3 GTF2IRD2B HIP1 NSUN5P1 PMS2P10 FDPSP2 CCL26 NCF1C MIR4651 CCL24 POMZP3 PMS2P2 MDH2 SPDYE16 SPDYE5 YWHAG SRRM3 GTF2IP1 ZP3 SNORA14A LOC107986711 TRIM73 STYXL1 TMEM120A LOC441259 RHBDD2 LOC100133091
nsv428174	Chr.7:76305019 - 77220062 on Build GRCh38	Gain	SPDYE17 POMZP3 CCDC146 FGL2 DTX2P1-UPK3BP1-PMS2P11 SSC4D SPDYE16 PMS2P9 YWHAG SPDYE18 LOC105375355 DTX2 ZP3 FDPSP2 LOC100133091
nsv1148733	Chr.7:76353392 - 76365602 on Build GRCh38	Deletion	YWHAG
nsv1028665	Chr.7:76336044 - 76445651 on Build GRCh38	Gain	ZP3 SSC4D YWHAG
dgv120n16	Chr.7:75440769 - 76641919 on Build GRCh38	Deletion	POM121C GTF2IP7 SSC4D LOC105375355 DTX2 HSPB1 POR PMS2P3 HIP1 FDPSP2 CCL26 MIR4651 CCL24 POMZP3 MDH2 SPDYE16 SPDYE5 YWHAG SRRM3 ZP3 SNORA14A LOC107986711 STYXL1 TMEM120A RHBDD2 LOC100133091

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

G2/M transition of mitotic cell cycle
negative regulation of protein kinase activity
protein targeting
regulation of signal transduction
cellular response to insulin stimulus
regulation of neuron differentiation
regulation of synaptic plasticity
membrane organization
negative regulation of protein serine/threonine kinase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Function(s)

protein kinase C binding
insulin-like growth factor receptor binding
protein binding
protein kinase C inhibitor activity
protein domain specific binding
receptor tyrosine kinase binding
poly(A) RNA binding