Hs03646717_cn

• Gene Symbol: YWHAG
• Assay Reference Genome Location: Chr.7:76357601 on build GRCh38
• Cytoband: 7q11.23

Target Gene Details

• Entrez Gene ID: 7532
• Gene Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
• Gene Aliases: 14-3-3GAMMA, PPP1R170
• Location: Chr.7:76326791-76359025 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
YWHAG	NM_012479.3			NP_036611.2
	AB024334.1			BAA85184.1
	AF142498.1			AAD48408.1
	AK024230.1
	AK293505.1
	AK295029.1
	BC020963.2			AAH20963.1
	CR541904.1			CAG46702.1
	CR541925.1			CAG46723.1
	DC343104.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2422494	Chr.7:76286900 - 76984449 on Build GRCh38	Duplication	ZP3 SSC4D DTX2 SRRM3 LOC100133091 DTX2P1-UPK3BP1-PMS2P11 YWHAG POMZP3 FDPSP2 SPDYE16 LOC105375355 HSPB1
nsv528969	Chr.7:75074053 - 76920728 on Build GRCh38	Gain	TRIM73 SRRM3 LOC541473 TMEM120A YWHAG MDH2 PMS2P2 SSC4D DTX2 SPDYE5 GTF2IRD2B FDPSP2 GTF2IP7 SPDYE16 LOC105375355 HIP1 LOC441259 POM121C ZP3 RHBDD2 GTF2IP1 CCL24 LOC107986711 LOC100133091 POR POMZP3 STYXL1 PMS2P3 CCL26 HSPB1 STAG3L1 MIR4651 NSUN5P1 SNORA14A PMS2P10 NCF1C
nsv428174	Chr.7:76305019 - 77220062 on Build GRCh38	Gain	ZP3 LOC100133091 SPDYE18 SPDYE17 PMS2P9 YWHAG POMZP3 FGL2 CCDC146 SSC4D DTX2 DTX2P1-UPK3BP1-PMS2P11 FDPSP2 SPDYE16 LOC105375355
nsv1148733	Chr.7:76353392 - 76365602 on Build GRCh38	Deletion	YWHAG
nsv1028665	Chr.7:76336044 - 76445651 on Build GRCh38	Gain	ZP3 SSC4D YWHAG
dgv120n16	Chr.7:75440769 - 76641919 on Build GRCh38	Deletion	SRRM3 TMEM120A YWHAG MDH2 SSC4D DTX2 SPDYE5 FDPSP2 GTF2IP7 SPDYE16 LOC105375355 HIP1 POM121C ZP3 RHBDD2 CCL24 LOC107986711 LOC100133091 POR POMZP3 STYXL1 PMS2P3 CCL26 HSPB1 MIR4651 SNORA14A

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

G2/M transition of mitotic cell cycle
negative regulation of protein kinase activity
protein targeting
regulation of signal transduction
cellular response to insulin stimulus
regulation of neuron differentiation
regulation of synaptic plasticity
membrane organization
negative regulation of protein serine/threonine kinase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Function(s)

protein kinase C binding
insulin-like growth factor receptor binding
protein binding
protein kinase C inhibitor activity
protein domain specific binding
receptor tyrosine kinase binding
poly(A) RNA binding