Hs03657633_cn

• Gene Symbol: EXOSC4
• Assay Reference Genome Location: Chr.8:144065297 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 54512
• Gene Name: exosome component 4
• Gene Aliases: RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
• Location: Chr.8:144064092-144080648 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC4	XM_011517134.2			XP_011515436.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	BOP1 SLC52A2 ADCK5 DGAT1 LOC101928902 SPATC1 WDR97 PARP10 PPP1R16A PLEC GPAA1 MIR6847 MIR6848 OPLAH MIR939 MIR1234 GPT HGH1 MAF1 SCX SCRT1 MIR6846 HSF1 SLC39A4 GRINA SHARPIN FOXH1 TMEM249 CPSF1 VPS28 MROH1 KIFC2 FBXL6 EXOSC4 CYHR1 LOC101928953 MIR6849 SMPD5 MIR6893 TONSL-AS1 RECQL4 CYC1 TONSL MFSD3 MIR661 LRRC14 MIR7112
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	GRINA SHARPIN SPATC1 EXOSC4 WDR97 PARP10 PLEC GPAA1 SMPD5 MIR6847 OPLAH CYC1 MAF1 MIR6846
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	GRINA SHARPIN SPATC1 EPPK1 EXOSC4 WDR97 PARP10 PLEC GPAA1 SMPD5 MIR6847 OPLAH CYC1 MAF1 MIR6846 MIR661
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	GRINA SPATC1 EPPK1 EXOSC4 PARP10 PLEC LOC642574 SCRIB SMPD5 MIR6845 MIR6847 OPLAH PUF60 MIR937 MIR6846 MIR661 NRBP2
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	BOP1 SHARPIN MROH1 SPATC1 EXOSC4 WDR97 GPAA1 SMPD5 MIR6847 OPLAH HGH1 CYC1 MAF1 SCX MIR6846 HSF1 MIR7112
nsv466014	Chr.8:144007080 - 144224185 on Build GRCh38	Loss	SHARPIN MROH1 SPATC1 EXOSC4 WDR97 GPAA1 SMPD5 MIR6847 OPLAH HGH1 CYC1 MAF1 MIR6846
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	BOP1 SLC52A2 ADCK5 DGAT1 LOC101928902 SPATC1 WDR97 PARP10 PPP1R16A PLEC GPAA1 MIR6847 MIR6848 OPLAH MIR939 MIR1234 GPT HGH1 MAF1 SCX SCRT1 MIR6846 HSF1 SLC39A4 GRINA SHARPIN FOXH1 TMEM249 CPSF1 VPS28 MROH1 KIFC2 FBXL6 EXOSC4 CYHR1 LOC101928953 MIR6849 SMPD5 MIR6893 TONSL-AS1 RECQL4 CYC1 TONSL MFSD3 MIR661 LRRC14 MIR7112
nsv6447	Chr.8:144064665 - 144087389 on Build GRCh38	Insertion	MIR6847 EXOSC4 GPAA1
dgv906n27	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	GRINA SHARPIN MROH1 SPATC1 EPPK1 EXOSC4 WDR97 PARP10 PLEC GPAA1 SMPD5 MIR6847 OPLAH HGH1 CYC1 MAF1 MIR6846 MIR661
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	GRINA SHARPIN SPATC1 EXOSC4 WDR97 PARP10 PLEC GPAA1 SMPD5 MIR6847 OPLAH CYC1 MAF1 MIR6846 MIR661
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	GRINA SMPD5 MIR6847 OPLAH CYC1 SPATC1 MIR6846 EXOSC4 MIR661 PARP10 PLEC GPAA1
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	BOP1 SLC52A2 ADCK5 DGAT1 LOC101928902 SPATC1 WDR97 PPP1R16A GPAA1 ARHGAP39 ZNF251 MIR6847 MIR6848 OPLAH MIR939 MIR1234 GPT HGH1 MAF1 SCX SCRT1 MIR6846 HSF1 SLC39A4 SHARPIN FOXH1 TMEM249 CPSF1 VPS28 MROH1 KIFC2 FBXL6 EXOSC4 CYHR1 LOC101928953 C8orf82 MIR6849 SMPD5 MIR6893 TONSL-AS1 RECQL4 CYC1 TONSL MFSD3 LRRC24 LRRC14 MIR7112
nsv612907	Chr.8:143917935 - 144097007 on Build GRCh38	Gain+Loss	GRINA SMPD5 MIR6847 OPLAH CYC1 SPATC1 MIR6846 EXOSC4 MIR661 PARP10 PLEC GPAA1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

exoribonuclease

Gene Ontology Categories:

Process(es)

maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
exoribonuclease activity
protein binding
AU-rich element binding