Hs03677503_cn

• Gene Symbol: EXOSC4
• Assay Reference Genome Location: Chr.8:144068493 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 54512
• Gene Name: exosome component 4
• Gene Aliases: RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
• Location: Chr.8:144064092-144080648 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC4	XM_011517134.2			XP_011515436.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	MROH1 SLC52A2 LOC101928953 TONSL-AS1 HSF1 SHARPIN MIR6848 MAF1 MFSD3 VPS28 FBXL6 DGAT1 PLEC SLC39A4 LOC101928902 CYHR1 PARP10 BOP1 MIR1234 MIR661 CYC1 SCRT1 FOXH1 SPATC1 LRRC14 OPLAH KIFC2 GPT ADCK5 SMPD5 PPP1R16A GRINA WDR97 HGH1 MIR6846 TONSL MIR7112 GPAA1 RECQL4 TMEM249 SCX MIR6847 EXOSC4 CPSF1 MIR6849 MIR939 MIR6893
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	SPATC1 OPLAH SHARPIN SMPD5 MAF1 PLEC GRINA WDR97 PARP10 MIR6846 GPAA1 MIR6847 EXOSC4 CYC1
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	SPATC1 OPLAH SHARPIN SMPD5 MAF1 PLEC GRINA WDR97 PARP10 EPPK1 MIR6846 GPAA1 MIR6847 EXOSC4 MIR661 CYC1
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	SCRIB SPATC1 OPLAH SMPD5 PLEC GRINA PARP10 EPPK1 MIR6846 MIR937 PUF60 NRBP2 LOC642574 MIR6847 EXOSC4 MIR661 MIR6845
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	MROH1 SPATC1 OPLAH HSF1 SHARPIN SMPD5 MAF1 WDR97 HGH1 MIR6846 MIR7112 GPAA1 BOP1 SCX MIR6847 EXOSC4 CYC1
esv29971	Chr.8:144068526 - 144172197 on Build GRCh38	Loss	MROH1 WDR97 HGH1 GPAA1 SHARPIN MAF1 MIR6847 EXOSC4 CYC1
nsv466014	Chr.8:144007080 - 144224185 on Build GRCh38	Loss	MROH1 SPATC1 OPLAH SHARPIN SMPD5 MAF1 WDR97 HGH1 MIR6846 GPAA1 MIR6847 EXOSC4 CYC1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	MROH1 SLC52A2 LOC101928953 TONSL-AS1 HSF1 SHARPIN MIR6848 MAF1 MFSD3 VPS28 FBXL6 DGAT1 PLEC SLC39A4 LOC101928902 CYHR1 PARP10 BOP1 MIR1234 MIR661 CYC1 SCRT1 FOXH1 SPATC1 LRRC14 OPLAH KIFC2 GPT ADCK5 SMPD5 PPP1R16A GRINA WDR97 HGH1 MIR6846 TONSL MIR7112 GPAA1 RECQL4 TMEM249 SCX MIR6847 EXOSC4 CPSF1 MIR6849 MIR939 MIR6893
nsv6447	Chr.8:144064665 - 144087389 on Build GRCh38	Insertion	GPAA1 MIR6847 EXOSC4
dgv906n27	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	MROH1 SPATC1 OPLAH SHARPIN SMPD5 MAF1 PLEC GRINA WDR97 PARP10 HGH1 EPPK1 MIR6846 GPAA1 MIR6847 EXOSC4 MIR661 CYC1
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	SPATC1 OPLAH SHARPIN SMPD5 MAF1 PLEC GRINA WDR97 PARP10 MIR6846 GPAA1 MIR6847 EXOSC4 MIR661 CYC1
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	PARP10 SPATC1 MIR6846 OPLAH GPAA1 SMPD5 MIR6847 EXOSC4 PLEC MIR661 CYC1 GRINA
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	MROH1 ZNF251 SLC52A2 LOC101928953 TONSL-AS1 HSF1 SHARPIN MIR6848 MAF1 MFSD3 VPS28 FBXL6 DGAT1 SLC39A4 LOC101928902 CYHR1 BOP1 MIR1234 C8orf82 CYC1 SCRT1 FOXH1 SPATC1 LRRC14 OPLAH KIFC2 GPT ADCK5 ARHGAP39 SMPD5 PPP1R16A WDR97 HGH1 MIR6846 TONSL LRRC24 MIR7112 GPAA1 RECQL4 TMEM249 SCX MIR6847 EXOSC4 CPSF1 MIR6849 MIR939 MIR6893
nsv612907	Chr.8:143917935 - 144097007 on Build GRCh38	Gain+Loss	PARP10 SPATC1 MIR6846 OPLAH GPAA1 SMPD5 MIR6847 EXOSC4 PLEC MIR661 CYC1 GRINA

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

exoribonuclease

Gene Ontology Categories:

Process(es)

maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
exoribonuclease activity
protein binding
AU-rich element binding