Hs03677503_cn

• Gene Symbol: EXOSC4
• Assay Reference Genome Location: Chr.8:144068493 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 54512
• Gene Name: exosome component 4
• Gene Aliases: RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
• Location: Chr.8:144064092-144080648 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC4	XM_011517134.2			XP_011515436.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	MIR6846 DGAT1 PPP1R16A BOP1 MIR6893 ADCK5 FBXL6 SCX SLC39A4 MIR1234 MIR939 MFSD3 SLC52A2 MAF1 MIR6847 EXOSC4 GPAA1 GPT LOC101928953 MROH1 SPATC1 CPSF1 CYC1 FOXH1 MIR7112 MIR6848 LOC101928902 SCRT1 RECQL4 VPS28 GRINA PARP10 LRRC14 TONSL HGH1 PLEC MIR661 SHARPIN TMEM249 MIR6849 KIFC2 WDR97 CYHR1 HSF1 OPLAH SMPD5 TONSL-AS1
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	MIR6846 GRINA PARP10 PLEC MAF1 MIR6847 SHARPIN EXOSC4 GPAA1 WDR97 OPLAH SMPD5 SPATC1 CYC1
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	MIR6846 EPPK1 GRINA PARP10 PLEC MIR661 MAF1 MIR6847 SHARPIN EXOSC4 GPAA1 WDR97 OPLAH SMPD5 SPATC1 CYC1
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	MIR6846 LOC642574 PUF60 MIR937 NRBP2 EPPK1 GRINA PARP10 SCRIB PLEC MIR661 MIR6847 EXOSC4 MIR6845 OPLAH SMPD5 SPATC1
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	MIR6846 MIR7112 BOP1 SCX HGH1 MAF1 MIR6847 SHARPIN EXOSC4 GPAA1 WDR97 HSF1 OPLAH SMPD5 MROH1 SPATC1 CYC1
esv29971	Chr.8:144068526 - 144172197 on Build GRCh38	Loss	HGH1 MAF1 MIR6847 SHARPIN EXOSC4 GPAA1 WDR97 MROH1 CYC1
nsv612915	Chr.8:144007080 - 144224185 on Build GRCh38	Loss	MIR6846 HGH1 MAF1 MIR6847 SHARPIN EXOSC4 GPAA1 WDR97 OPLAH SMPD5 MROH1 SPATC1 CYC1
nsv6447	Chr.8:144064665 - 144087389 on Build GRCh38	Insertion	MIR6847 EXOSC4 GPAA1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	MIR6846 DGAT1 PPP1R16A BOP1 MIR6893 ADCK5 FBXL6 SCX SLC39A4 MIR1234 MIR939 MFSD3 SLC52A2 MAF1 MIR6847 EXOSC4 GPAA1 GPT LOC101928953 MROH1 SPATC1 CPSF1 CYC1 FOXH1 MIR7112 MIR6848 LOC101928902 SCRT1 RECQL4 VPS28 GRINA PARP10 LRRC14 TONSL HGH1 PLEC MIR661 SHARPIN TMEM249 MIR6849 KIFC2 WDR97 CYHR1 HSF1 OPLAH SMPD5 TONSL-AS1
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	MIR6846 EPPK1 GRINA PARP10 HGH1 PLEC MIR661 MAF1 MIR6847 SHARPIN EXOSC4 GPAA1 WDR97 OPLAH SMPD5 MROH1 SPATC1 CYC1
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	MIR6846 DGAT1 PPP1R16A BOP1 MIR6893 ADCK5 FBXL6 SCX SLC39A4 MIR1234 C8orf82 MIR939 MFSD3 SLC52A2 MAF1 MIR6847 ARHGAP39 EXOSC4 GPAA1 GPT LOC101928953 MROH1 SPATC1 CPSF1 CYC1 ZNF251 FOXH1 MIR7112 MIR6848 LOC101928902 SCRT1 LRRC24 RECQL4 VPS28 LRRC14 TONSL HGH1 SHARPIN TMEM249 MIR6849 KIFC2 WDR97 CYHR1 HSF1 OPLAH SMPD5 TONSL-AS1
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	MIR6846 PLEC MIR661 MIR6847 EXOSC4 GPAA1 OPLAH SMPD5 GRINA PARP10 SPATC1 CYC1
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	MIR6846 GRINA PARP10 PLEC MIR661 MAF1 MIR6847 SHARPIN EXOSC4 GPAA1 WDR97 OPLAH SMPD5 SPATC1 CYC1
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	MIR6846 PLEC MIR661 MIR6847 EXOSC4 GPAA1 OPLAH SMPD5 GRINA PARP10 SPATC1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

exoribonuclease

Gene Ontology Categories:

Process(es)

maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
exoribonuclease activity
protein binding
AU-rich element binding