Hs03684165_cn

• Gene Symbol: EXOSC4
• Assay Reference Genome Location: Chr.8:144064370 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 54512
• Gene Name: exosome component 4
• Gene Aliases: RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
• Location: Chr.8:144064092-144080648 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC4	XM_011517134.2			XP_011515436.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv612915	Chr.8:144007080 - 144224185 on Build GRCh38	Loss	SPATC1 MAF1 MIR6847 HGH1 SMPD5 MIR6846 MROH1 EXOSC4 SHARPIN GPAA1 OPLAH WDR97 CYC1
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	TMEM249 MIR7112 DGAT1 LOC101928902 MAF1 LRRC14 KIFC2 SLC39A4 MIR1234 MIR939 CYHR1 SCX RECQL4 HSF1 MIR6846 CPSF1 SHARPIN GPAA1 MIR6893 GRINA WDR97 FOXH1 MIR6849 GPT BOP1 TONSL-AS1 SLC52A2 PPP1R16A SPATC1 MIR6847 HGH1 VPS28 MFSD3 SMPD5 MIR6848 MIR661 ADCK5 MROH1 EXOSC4 PLEC TONSL LOC101928953 SCRT1 OPLAH FBXL6 PARP10 CYC1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	TMEM249 MIR7112 DGAT1 LOC101928902 MAF1 LRRC14 KIFC2 SLC39A4 MIR1234 MIR939 CYHR1 SCX RECQL4 HSF1 MIR6846 CPSF1 SHARPIN GPAA1 MIR6893 GRINA WDR97 FOXH1 MIR6849 GPT BOP1 TONSL-AS1 SLC52A2 PPP1R16A SPATC1 MIR6847 HGH1 VPS28 MFSD3 SMPD5 MIR6848 MIR661 ADCK5 MROH1 EXOSC4 PLEC TONSL LOC101928953 SCRT1 OPLAH FBXL6 PARP10 CYC1
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	SPATC1 MAF1 MIR6847 SMPD5 MIR6846 EXOSC4 SHARPIN PLEC GPAA1 OPLAH GRINA WDR97 PARP10 CYC1
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	EPPK1 SPATC1 MAF1 MIR6847 HGH1 SMPD5 MIR6846 MIR661 MROH1 EXOSC4 SHARPIN PLEC GPAA1 OPLAH GRINA WDR97 PARP10 CYC1
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	EPPK1 SPATC1 MAF1 MIR6847 SMPD5 MIR6846 MIR661 EXOSC4 SHARPIN PLEC GPAA1 OPLAH GRINA WDR97 PARP10 CYC1
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	SCRIB EPPK1 NRBP2 MIR6845 MIR937 LOC642574 SPATC1 PUF60 MIR6847 SMPD5 MIR6846 MIR661 EXOSC4 PLEC OPLAH GRINA PARP10
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	BOP1 MIR7112 SPATC1 MAF1 MIR6847 HGH1 SCX SMPD5 HSF1 MIR6846 MROH1 EXOSC4 SHARPIN GPAA1 OPLAH WDR97 CYC1
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	TMEM249 MIR7112 DGAT1 LOC101928902 MAF1 LRRC14 KIFC2 SLC39A4 MIR1234 MIR939 CYHR1 SCX RECQL4 HSF1 MIR6846 CPSF1 SHARPIN GPAA1 MIR6893 WDR97 FOXH1 ZNF251 MIR6849 GPT BOP1 TONSL-AS1 SLC52A2 LRRC24 PPP1R16A SPATC1 MIR6847 HGH1 VPS28 C8orf82 MFSD3 SMPD5 MIR6848 ADCK5 MROH1 EXOSC4 TONSL LOC101928953 SCRT1 ARHGAP39 OPLAH FBXL6 CYC1
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	SMPD5 MIR6846 MIR661 EXOSC4 PLEC GPAA1 SPATC1 OPLAH MIR6847 GRINA PARP10 CYC1
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	SPATC1 MAF1 MIR6847 SMPD5 MIR6846 MIR661 EXOSC4 SHARPIN PLEC GPAA1 OPLAH GRINA WDR97 PARP10 CYC1
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	SMPD5 MIR6846 MIR661 EXOSC4 PLEC GPAA1 SPATC1 OPLAH MIR6847 GRINA PARP10

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

exoribonuclease

Gene Ontology Categories:

Process(es)

maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
exoribonuclease activity
protein binding
AU-rich element binding