Hs03684165_cn

• Gene Symbol: EXOSC4
• Assay Reference Genome Location: Chr.8:144064370 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 54512
• Gene Name: exosome component 4
• Gene Aliases: RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
• Location: Chr.8:144064092-144080648 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC4	XM_011517134.2			XP_011515436.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	MROH1 MFSD3 CYC1 TONSL-AS1 KIFC2 MIR6849 SMPD5 PLEC TONSL GPAA1 PPP1R16A CPSF1 MIR661 MIR6847 DGAT1 SPATC1 SCRT1 TMEM249 MIR1234 FOXH1 WDR97 SHARPIN SLC52A2 SCX CYHR1 MIR6848 MIR6893 LRRC14 MIR6846 MIR7112 MAF1 LOC101928902 BOP1 FBXL6 PARP10 EXOSC4 SLC39A4 HGH1 HSF1 MIR939 LOC101928953 RECQL4 GRINA ADCK5 OPLAH VPS28 GPT
nsv466014	Chr.8:144007080 - 144224185 on Build GRCh38	Loss	MROH1 CYC1 WDR97 SHARPIN SMPD5 GPAA1 MIR6846 MAF1 EXOSC4 HGH1 OPLAH MIR6847 SPATC1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	MROH1 MFSD3 CYC1 TONSL-AS1 KIFC2 MIR6849 SMPD5 PLEC TONSL GPAA1 PPP1R16A CPSF1 MIR661 MIR6847 DGAT1 SPATC1 SCRT1 TMEM249 MIR1234 FOXH1 WDR97 SHARPIN SLC52A2 SCX CYHR1 MIR6848 MIR6893 LRRC14 MIR6846 MIR7112 MAF1 LOC101928902 BOP1 FBXL6 PARP10 EXOSC4 SLC39A4 HGH1 HSF1 MIR939 LOC101928953 RECQL4 GRINA ADCK5 OPLAH VPS28 GPT
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	CYC1 WDR97 SHARPIN SMPD5 PLEC GPAA1 MIR6846 MAF1 PARP10 EXOSC4 GRINA OPLAH MIR6847 SPATC1
dgv906n27	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	MROH1 CYC1 WDR97 SHARPIN SMPD5 PLEC GPAA1 MIR6846 EPPK1 MAF1 PARP10 EXOSC4 HGH1 MIR661 GRINA OPLAH MIR6847 SPATC1
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	CYC1 WDR97 SHARPIN SMPD5 PLEC GPAA1 MIR6846 EPPK1 MAF1 PARP10 EXOSC4 MIR661 GRINA OPLAH MIR6847 SPATC1
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	NRBP2 SMPD5 PLEC PUF60 MIR6846 EPPK1 SCRIB PARP10 EXOSC4 MIR6845 MIR661 GRINA MIR937 OPLAH MIR6847 SPATC1 LOC642574
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	CYC1 WDR97 SHARPIN SMPD5 PLEC GPAA1 MIR6846 MAF1 PARP10 EXOSC4 MIR661 GRINA OPLAH MIR6847 SPATC1
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	CYC1 PARP10 EXOSC4 SMPD5 MIR661 PLEC GRINA GPAA1 OPLAH MIR6847 SPATC1 MIR6846
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	MROH1 MFSD3 CYC1 LRRC24 TONSL-AS1 KIFC2 MIR6849 SMPD5 TONSL ZNF251 GPAA1 PPP1R16A CPSF1 C8orf82 MIR6847 DGAT1 SPATC1 SCRT1 TMEM249 MIR1234 FOXH1 WDR97 SHARPIN SLC52A2 SCX CYHR1 MIR6848 MIR6893 LRRC14 ARHGAP39 MIR6846 MIR7112 MAF1 LOC101928902 BOP1 FBXL6 EXOSC4 SLC39A4 HGH1 HSF1 MIR939 LOC101928953 RECQL4 ADCK5 OPLAH VPS28 GPT
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	MROH1 CYC1 WDR97 SHARPIN SCX SMPD5 GPAA1 MIR6846 MIR7112 MAF1 BOP1 EXOSC4 HGH1 HSF1 OPLAH MIR6847 SPATC1
nsv612907	Chr.8:143917935 - 144097007 on Build GRCh38	Gain+Loss	CYC1 PARP10 EXOSC4 SMPD5 MIR661 PLEC GRINA GPAA1 OPLAH MIR6847 SPATC1 MIR6846

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

exoribonuclease

Gene Ontology Categories:

Process(es)

maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
exoribonuclease activity
protein binding
AU-rich element binding