Hs03697182_cn

• Gene Symbol: EXOSC4
• Assay Reference Genome Location: Chr.8:144077359 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 54512
• Gene Name: exosome component 4
• Gene Aliases: RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
• Location: Chr.8:144064092-144080648 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC4	XM_011517134.2			XP_011515436.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2759651	Chr.8:144076281 - 144230741 on Build GRCh38	Gain	MIR6847 HGH1 MAF1 WDR97 SHARPIN MROH1 GPAA1 CYC1 EXOSC4
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	LRRC14 MIR6847 PLEC HSF1 KIFC2 BOP1 TONSL LOC101928953 OPLAH MAF1 WDR97 CYHR1 SLC39A4 MROH1 GPAA1 SMPD5 MIR6846 GRINA RECQL4 MIR6849 MIR7112 FOXH1 SCX TONSL-AS1 CPSF1 SPATC1 CYC1 EXOSC4 MIR1234 DGAT1 MFSD3 ADCK5 HGH1 MIR6893 PPP1R16A SHARPIN MIR661 MIR6848 FBXL6 LOC101928902 TMEM249 PARP10 VPS28 MIR939 SLC52A2 SCRT1 GPT
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	MIR6847 PLEC OPLAH MAF1 WDR97 SHARPIN GPAA1 SMPD5 MIR6846 GRINA PARP10 SPATC1 CYC1 EXOSC4
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	MIR6847 PLEC OPLAH MAF1 WDR97 SHARPIN GPAA1 SMPD5 MIR661 MIR6846 GRINA EPPK1 PARP10 SPATC1 CYC1 EXOSC4
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	PUF60 MIR6847 PLEC LOC642574 OPLAH SCRIB MIR937 SMPD5 MIR661 MIR6846 MIR6845 GRINA EPPK1 NRBP2 PARP10 SPATC1 EXOSC4
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	MIR6847 HSF1 HGH1 BOP1 OPLAH MAF1 WDR97 SHARPIN MROH1 GPAA1 SMPD5 MIR6846 MIR7112 SCX SPATC1 CYC1 EXOSC4
esv29971	Chr.8:144068526 - 144172197 on Build GRCh38	Loss	MIR6847 HGH1 MAF1 WDR97 SHARPIN MROH1 GPAA1 CYC1 EXOSC4
nsv466014	Chr.8:144007080 - 144224185 on Build GRCh38	Loss	MIR6847 HGH1 OPLAH MAF1 WDR97 SHARPIN MROH1 GPAA1 SMPD5 MIR6846 SPATC1 CYC1 EXOSC4
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	LRRC14 MIR6847 PLEC HSF1 KIFC2 BOP1 TONSL LOC101928953 OPLAH MAF1 WDR97 CYHR1 SLC39A4 MROH1 GPAA1 SMPD5 MIR6846 GRINA RECQL4 MIR6849 MIR7112 FOXH1 SCX TONSL-AS1 CPSF1 SPATC1 CYC1 EXOSC4 MIR1234 DGAT1 MFSD3 ADCK5 HGH1 MIR6893 PPP1R16A SHARPIN MIR661 MIR6848 FBXL6 LOC101928902 TMEM249 PARP10 VPS28 MIR939 SLC52A2 SCRT1 GPT
nsv6447	Chr.8:144064665 - 144087389 on Build GRCh38	Insertion	MIR6847 GPAA1 EXOSC4
dgv906n27	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	MIR6847 PLEC HGH1 OPLAH MAF1 WDR97 SHARPIN MROH1 GPAA1 SMPD5 MIR661 MIR6846 GRINA EPPK1 PARP10 SPATC1 CYC1 EXOSC4
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	MIR6847 PLEC OPLAH MAF1 WDR97 SHARPIN GPAA1 SMPD5 MIR661 MIR6846 GRINA PARP10 SPATC1 CYC1 EXOSC4
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	MIR6847 PLEC PARP10 OPLAH GPAA1 SPATC1 SMPD5 CYC1 EXOSC4 MIR661 MIR6846 GRINA
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	LRRC14 MIR6847 HSF1 LRRC24 KIFC2 BOP1 TONSL LOC101928953 OPLAH MAF1 WDR97 ARHGAP39 CYHR1 SLC39A4 MROH1 GPAA1 SMPD5 MIR6846 RECQL4 ZNF251 MIR6849 C8orf82 MIR7112 FOXH1 SCX TONSL-AS1 CPSF1 SPATC1 CYC1 EXOSC4 MIR1234 DGAT1 MFSD3 ADCK5 HGH1 MIR6893 PPP1R16A SHARPIN MIR6848 FBXL6 LOC101928902 TMEM249 VPS28 MIR939 SLC52A2 SCRT1 GPT
nsv612907	Chr.8:143917935 - 144097007 on Build GRCh38	Gain+Loss	MIR6847 PLEC PARP10 OPLAH GPAA1 SPATC1 SMPD5 CYC1 EXOSC4 MIR661 MIR6846 GRINA

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

exoribonuclease

Gene Ontology Categories:

Process(es)

maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
exoribonuclease activity
protein binding
AU-rich element binding