Hs03724812_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136882312 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	RABL6 EDF1 MIR4479 TRAF2 FBXW5 C9orf172 MAMDC4 PHPT1 MIR4292
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	LOC100128593 PTGDS TRAF2 LCN6 CCDC183-AS1 LCNL1 LCN15 CLIC3 RABL6 C9orf142 CCDC183 PRR31 TMEM141 LCN10 MIR4292 MIR4479 ABCA2 C8G MAMDC4 LCN12 LCN8 EDF1 FBXW5 C9orf172 MIR6722 PHPT1
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	SAPCD2 TMEM210 LCNL1 CLIC3 RABL6 C9orf142 CCDC183 PRR31 MAN1B1 SSNA1 MIR3621 LOC101930307 MIR4292 NRARP TUBB4B RNF208 ABCA2 NOXA1 C8G ENTPD2 NELFB PNPLA7 LCN12 MIR7114 EDF1 ANAPC2 NSMF FBXW5 LRRC26 TPRN C9orf139 PHPT1 NDOR1 TOR4A PTGDS TRAF2 GRIN1 CCDC183-AS1 FAM166A FUT7 MAN1B1-AS1 UAP1L1 C9orf173-AS1 MIR4479 EXD3 DPP7 SLC34A3 MAMDC4 STPG3 CYSRT1 ENTPD8 TMEM203 C9orf172 NPDC1 RNF224
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	SAPCD2 FAM69B TMEM210 LCNL1 LCN15 CLIC3 RABL6 C9orf142 CCDC183 PRR31 SNORA17B MAN1B1 MIR3621 SDCCAG3 LOC101930307 LCN10 MIR4292 SEC16A ABCA2 C9orf163 C8G ENTPD2 MIR4674 SNAPC4 LCN12 NOTCH1 EDF1 FBXW5 LRRC26 C9orf139 PHPT1 LOC100128593 PTGDS TRAF2 GRIN1 LCN6 CARD9 CCDC183-AS1 LINC01451 MIR4673 FUT7 TMEM141 MAN1B1-AS1 UAP1L1 MIR126 EGFL7 INPP5E MIR4479 DPP7 DNLZ MAMDC4 SNORA17A AGPAT2 LCN8 PMPCA NALT1 HSPC324 C9orf172 MIR6722 NPDC1 SNHG7
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	LOC100128593 FAM69B TRAF2 LCN6 CARD9 CCDC183-AS1 LINC01451 LCN15 RABL6 MIR4673 CCDC183 SNORA17B TMEM141 SDCCAG3 LCN10 MIR4292 MIR126 EGFL7 INPP5E MIR4479 GPSM1 SEC16A C9orf163 DNLZ MAMDC4 MIR4674 SNAPC4 SNORA17A AGPAT2 NOTCH1 LCN8 PMPCA NALT1 EDF1 HSPC324 C9orf172 MIR6722 PHPT1 SNHG7
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	SAPCD2 FAM69B TMEM210 LCNL1 LCN15 CLIC3 RABL6 C9orf142 CCDC183 PRR31 SNORA17B MAN1B1 SSNA1 MIR3621 LOC101930307 LCN10 MIR4292 NRARP TUBB4B RNF208 ABCA2 C8G ENTPD2 NELFB LCN12 EDF1 ANAPC2 FBXW5 LRRC26 TPRN C9orf139 PHPT1 NDOR1 TOR4A LOC100128593 PTGDS TRAF2 GRIN1 LCN6 CCDC183-AS1 FAM166A LINC01451 FUT7 TMEM141 MAN1B1-AS1 UAP1L1 C9orf173-AS1 MIR126 EGFL7 MIR4479 EXD3 DPP7 SLC34A3 MAMDC4 STPG3 CYSRT1 SNORA17A TMEM203 AGPAT2 LCN8 HSPC324 C9orf172 MIR6722 NPDC1 RNF224 SNHG7

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding