Hs03724812_cn

• Gene Symbol: TRAF2
• Assay Reference Genome Location: Chr.9:136882312 on build GRCh38
• Cytoband: 9q34.3

Target Gene Details

• Entrez Gene ID: 7186
• Gene Name: TNF receptor associated factor 2
• Gene Aliases: MGC:45012, TRAP, TRAP3
• Location: Chr.9:136881776-136926615 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TRAF2	XM_011518973.2			XP_011517275.1
	XM_011518976.2			XP_011517278.1
	AK289722.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv951205	Chr.9:136821949 - 136944648 on Build GRCh38	Deletion	MAMDC4 MIR4292 FBXW5 C9orf172 RABL6 EDF1 TRAF2 PHPT1 MIR4479
nsv818738	Chr.9:136740043 - 137009585 on Build GRCh38	Gain	LOC100128593 LCNL1 ABCA2 RABL6 PRR31 C8G TMEM141 TRAF2 PHPT1 PTGDS MIR4479 MAMDC4 C9orf142 FBXW5 LCN10 CCDC183-AS1 MIR6722 LCN15 MIR4292 CCDC183 CLIC3 C9orf172 LCN8 LCN12 EDF1 LCN6
nsv524322	Chr.9:136795692 - 137482216 on Build GRCh38	Loss	UAP1L1 LCNL1 ABCA2 TMEM210 LOC101930307 ENTPD2 C8G NOXA1 MAN1B1 PHPT1 TOR4A MIR4479 CYSRT1 C9orf142 FBXW5 LRRC26 C9orf139 CCDC183 DPP7 C9orf173-AS1 SLC34A3 GRIN1 MIR3621 RNF208 PNPLA7 EDF1 EXD3 NELFB MAN1B1-AS1 FAM166A NPDC1 NRARP RABL6 SSNA1 PRR31 ANAPC2 TRAF2 TMEM203 PTGDS NDOR1 MAMDC4 FUT7 STPG3 CCDC183-AS1 ENTPD8 MIR4292 TUBB4B RNF224 CLIC3 C9orf172 SAPCD2 MIR7114 TPRN NSMF LCN12
esv2759720	Chr.9:136356377 - 136932033 on Build GRCh38	Loss	NOTCH1 SNORA17A LOC100128593 DNLZ NALT1 SEC16A RABL6 HSPC324 PMPCA TMEM141 MIR4673 TRAF2 PHPT1 SNORA17B FAM69B MIR4479 EGFL7 MAMDC4 SNHG7 C9orf163 LCN10 SNAPC4 MIR126 CCDC183-AS1 MIR6722 LCN15 MIR4292 CCDC183 C9orf172 LCN8 INPP5E AGPAT2 LINC01451 SDCCAG3 MIR4674 EDF1 GPSM1 LCN6 CARD9
nsv469918	Chr.9:136359865 - 137173890 on Build GRCh38	Loss	NOTCH1 DNLZ NALT1 UAP1L1 LCNL1 ABCA2 TMEM210 LOC101930307 ENTPD2 PMPCA C8G TMEM141 MIR4673 MAN1B1 PHPT1 FAM69B MIR4479 EGFL7 C9orf142 FBXW5 MIR126 MIR6722 LRRC26 LCN15 C9orf139 CCDC183 DPP7 GRIN1 AGPAT2 MIR3621 SDCCAG3 MIR4674 EDF1 LCN6 CARD9 MAN1B1-AS1 SNORA17A LOC100128593 NPDC1 SEC16A RABL6 HSPC324 PRR31 TRAF2 SNORA17B PTGDS MAMDC4 SNHG7 C9orf163 FUT7 LCN10 SNAPC4 CCDC183-AS1 MIR4292 CLIC3 C9orf172 SAPCD2 LCN8 INPP5E LINC01451 LCN12
esv2422220	Chr.9:136584135 - 137350098 on Build GRCh38	Deletion	UAP1L1 LCNL1 ABCA2 TMEM210 LOC101930307 ENTPD2 C8G TMEM141 MAN1B1 PHPT1 TOR4A FAM69B MIR4479 EGFL7 CYSRT1 C9orf142 FBXW5 MIR126 MIR6722 LRRC26 LCN15 C9orf139 CCDC183 DPP7 C9orf173-AS1 SLC34A3 GRIN1 AGPAT2 MIR3621 RNF208 EDF1 LCN6 EXD3 NELFB MAN1B1-AS1 FAM166A SNORA17A LOC100128593 NPDC1 NRARP RABL6 SSNA1 HSPC324 PRR31 ANAPC2 TRAF2 TMEM203 SNORA17B PTGDS NDOR1 MAMDC4 SNHG7 FUT7 LCN10 STPG3 CCDC183-AS1 MIR4292 TUBB4B RNF224 CLIC3 C9orf172 SAPCD2 TPRN LCN8 LINC01451 LCN12

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

positive regulation of T cell cytokine production
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
I-kappaB kinase/NF-kappaB signaling
activation of NF-kappaB-inducing kinase activity
regulation of tumor necrosis factor-mediated signaling pathway
regulation of necrotic cell death
protein catabolic process
positive regulation of interleukin-2 production
tumor necrosis factor-mediated signaling pathway
negative regulation of glial cell apoptotic process
response to endoplasmic reticulum stress
regulation of apoptotic process
positive regulation of JUN kinase activity
cellular protein complex assembly
positive regulation of T cell activation
regulation of immunoglobulin secretion
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
protein autoubiquitination
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
protein homotrimerization
protein K63-linked ubiquitination
death-inducing signaling complex assembly
cellular response to nitric oxide
positive regulation of protein homodimerization activity
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
programmed necrotic cell death
negative regulation of neuron death
regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of I-kappaB phosphorylation
positive regulation of extrinsic apoptotic signaling pathway

Function(s)

ubiquitin-protein transferase activity
signal transducer activity
tumor necrosis factor receptor binding
CD40 receptor binding
protein binding
zinc ion binding
ligase activity
enzyme binding
protein kinase binding
protein phosphatase binding
mitogen-activated protein kinase kinase kinase binding
ubiquitin protein ligase binding
thioesterase binding
protein complex binding
identical protein binding
sphingolipid binding