Hs03808186_cn

• Gene Symbol: DDIT3
• Assay Reference Genome Location: Chr.12:57519743 on build GRCh38
• Cytoband: 12q13.3

Target Gene Details

• Entrez Gene ID: 1649
• Gene Name: DNA damage inducible transcript 3
• Gene Aliases: CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
• Location: Chr.12:57516588-57520517 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DDIT3	NM_001195053.1			NP_001181982.1
	NM_001195054.1			NP_001181983.1
	NM_001195055.1			NP_001181984.1
	NM_001195056.1			NP_001181985.1
	NM_001195057.1			NP_001181986.1
	NM_004083.5			NP_004074.2
	AA054097.1
	AA476561.1
	AK316581.1
	AV729744.1
	AY461580.1
	BC003637.2			AAH03637.1
	BM464290.1
	BU664077.1
	CN482428.1
	S40706.1			AAB22646.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2759901	Chr.12:57435950 - 57608085 on Build GRCh38	Gain	MIR616 DDIT3 KIF5A MIR6758 MARS INHBE PIP4K2C INHBC GLI1 DCTN2 MBD6 ARHGAP9 DTX3
nsv559034	Chr.12:57466149 - 57618450 on Build GRCh38	Loss	MIR616 DDIT3 KIF5A MIR6758 MARS PIP4K2C GLI1 LOC101927583 DCTN2 MBD6 ARHGAP9 DTX3 ARHGEF25
dgv2651n54	Chr.12:57450266 - 57552694 on Build GRCh38	Loss	INHBC MIR616 GLI1 DDIT3 KIF5A DCTN2 MBD6 ARHGAP9 MIR6758 MARS INHBE
nsv482992	Chr.12:56206217 - 57706217 on Build GRCh38	Gain+Loss	R3HDM2 NEMP1 APOF RDH16 KIF5A NACA STAT2 HBCBP RBMS2 COQ10A DCTN2 ARHGAP9 DTX3 NDUFA4L2 LRP1 ARHGEF25 SLC39A5 STAC3 NXPH4 MYO1A MIP TAC3 SDR9C7 B4GALNT1 BAZ2A PRIM1 IL23A PIP4K2C ZBTB39 NABP2 SNORD59A PAN2 LRP1-AS PTGES3 CS OS9 MIR6758 INHBC SNORD59B GLI1 GLS2 MBD6 SHMT2 ATP5B GPR182 ANKRD52 RNF41 STAT6 TIMELESS SNORA105C MIR616 DDIT3 HSD17B6 SLC26A10 CNPY2 MARS INHBE MIR1228 NAB2 LOC101927583 SPRYD4
nsv559036	Chr.12:57517429 - 57522259 on Build GRCh38	Loss	MIR616 DDIT3 MBD6

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
response to amphetamine
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
ER overload response
response to unfolded protein
cell cycle arrest
aging
response to nutrient
Wnt signaling pathway
positive regulation of interleukin-8 production
negative regulation of CREB transcription factor activity
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to drug
response to hydrogen peroxide
response to starvation
mRNA transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
regulation of DNA-templated transcription in response to stress
regulation of transcription involved in anterior/posterior axis specification
cell redox homeostasis
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of canonical Wnt signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of determination of dorsal identity

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
cAMP response element binding protein binding
protein homodimerization activity
leucine zipper domain binding
transcription regulatory region DNA binding
protein heterodimerization activity