Hs03809656_cn

• Gene Symbol: DDIT3
• Assay Reference Genome Location: Chr.12:57518314 on build GRCh38
• Cytoband: 12q13.3

Target Gene Details

• Entrez Gene ID: 1649
• Gene Name: DNA damage inducible transcript 3
• Gene Aliases: CEBPZ, CHOP, CHOP-10, CHOP10, GADD153
• Location: Chr.12:57516588-57520517 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DDIT3	NM_001195053.1			NP_001181982.1
	NM_001195054.1			NP_001181983.1
	NM_001195055.1			NP_001181984.1
	NM_001195056.1			NP_001181985.1
	NM_001195057.1			NP_001181986.1
	NM_004083.5			NP_004074.2
	AA054097.1
	AA476561.1
	AK316581.1
	AV729744.1
	AY461580.1
	BC003637.2			AAH03637.1
	BM464290.1
	BU664077.1
	CN482428.1
	S40706.1			AAB22646.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv428283	Chr.12:57435950 - 57608085 on Build GRCh38	Gain	GLI1 DCTN2 DTX3 INHBE MBD6 ARHGAP9 PIP4K2C MIR6758 INHBC MARS KIF5A DDIT3 MIR616
nsv559034	Chr.12:57466149 - 57618450 on Build GRCh38	Loss	ARHGEF25 GLI1 DCTN2 DTX3 LOC101927583 MBD6 ARHGAP9 PIP4K2C MIR6758 MARS KIF5A DDIT3 MIR616
nsv469411	Chr.12:57450266 - 57527405 on Build GRCh38	Loss	GLI1 INHBE MBD6 ARHGAP9 DDIT3 MIR616 MIR6758 INHBC MARS
nsv559036	Chr.12:57517429 - 57522259 on Build GRCh38	Loss	MBD6 DDIT3 MIR616
nsv482992	Chr.12:56206217 - 57706217 on Build GRCh38	Gain+Loss	ARHGEF25 GLI1 APOF CS RNF41 STAT2 IL23A ANKRD52 SNORA105C RBMS2 DDIT3 STAT6 SNORD59B B4GALNT1 NEMP1 GPR182 RDH16 LRP1 INHBC ZBTB39 PAN2 NAB2 PTGES3 SHMT2 PRIM1 MIR616 SNORD59A SLC26A10 CNPY2 STAC3 DTX3 LOC101927583 NACA MBD6 PIP4K2C ATP5B MIR6758 COQ10A LRP1-AS SPRYD4 NABP2 R3HDM2 NXPH4 MIP OS9 NDUFA4L2 DCTN2 INHBE ARHGAP9 GLS2 BAZ2A MIR1228 HSD17B6 MARS MYO1A SLC39A5 HBCBP TIMELESS KIF5A SDR9C7 TAC3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
response to amphetamine
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
ER overload response
response to unfolded protein
cell cycle arrest
aging
response to nutrient
Wnt signaling pathway
positive regulation of interleukin-8 production
negative regulation of CREB transcription factor activity
response to endoplasmic reticulum stress
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to drug
response to hydrogen peroxide
response to starvation
mRNA transcription from RNA polymerase II promoter
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
regulation of DNA-templated transcription in response to stress
regulation of transcription involved in anterior/posterior axis specification
cell redox homeostasis
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of canonical Wnt signaling pathway
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of determination of dorsal identity

Function(s)

transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
cAMP response element binding protein binding
protein homodimerization activity
leucine zipper domain binding
transcription regulatory region DNA binding
protein heterodimerization activity