Hs04009112_cn

• Gene Symbol: PPP1R15A
• Assay Reference Genome Location: Chr.19:48872873 on build GRCh38
• Cytoband: 19q13.33

Target Gene Details

• Entrez Gene ID: 23645
• Gene Name: protein phosphatase 1 regulatory subunit 15A
• Gene Aliases: GADD34
• Location: Chr.19:48872392-48876062 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PPP1R15A	NM_014330.3			NP_055145.3
	AK001361.1			BAA91649.1
	AK225632.1
	AK296668.1
	AK297615.1
	AK298765.1
	AK311366.1
	BC003067.2			AAH03067.1
	DA484808.1
	U83981.1			AAC25631.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv9739	Chr.19:47901840 - 50143063 on Build GRCh38	Gain+Loss	SNAR-A12 PLA2G4C NUCB1 CGB1 GFY LOC105372430 IRF3 MIR4324 SPACA4 MIR4750 SNAR-A4 SNORD35B SNAR-A2 SYNGR4 ZNF114 FLT3LG ATF5 CGB5 MIR6800 SNAR-C3 SNAR-A10 LHB SNRNP70 NTN5 C19orf68 NOSIP SNAR-A6 FAM83E ELSPBP1 FLJ26850 GRIN2D TSKS PIH1D1 CCDC114 MIR5088 HSD17B14 SEC1P DHDH RUVBL2 LIG1 FTL SNAR-A8 BCL2L12 SNORD34 SNAR-G1 SNAR-A1 SNAR-D RPL18 SNAR-B1 LOC101928295 NTF4 LOC101059948 SNAR-A3 SNAR-A13 MIR4751 SNAR-C4 CARD8-AS1 KCNA7 FUT1 CABP5 EMP3 SNAR-C2 C19orf73 SNAR-B2 RRAS MED25 TEAD2 MIR6798 SIGLEC16 CGB8 SLC17A7 RPS11 PNKP ADM5 BCAT2 SULT2B1 LOC105447645 PLEKHA4 IZUMO1 PLA2G4C-AS1 KCNJ14 DKKL1 HRC CYTH2 RASIP1 SNAR-A14 NUP62 CARD8 CD37 SPHK2 PPFIA3 PRRG2 SNAR-C1 RCN3 MIR4749 AP2A1 CGB2 GRWD1 SLC6A16 FUT2 SNAR-C5 SNAR-A9 CGB7 SNAR-A7 TMEM143 LMTK3 PTOV1-AS1 VRK3 BAX LIN7B AKT1S1 FCGRT CCDC155 DBP CGB3 MIR6799 BSPH1 SNAR-A5 SNORD35A FGF21 CA11 SNAR-G2 TRPM4 CPT1C PTH2 PTOV1 SIGLEC11 SNORD33 NUCB1-AS1 LOC100287477 PTOV1-AS2 SNORD32A MAMSTR SCAF1 KDELR1 TBC1D17 GYS1 PRR12 TULP2 PRMT1 ZNF473 MIR150 PPP1R15A IL4I1 ALDH16A1 SNAR-A11 RPL13A FUZ
nsv470148	Chr.19:48865586 - 48906934 on Build GRCh38	Gain	PPP1R15A NUCB1 TULP2 PLEKHA4
nsv833856	Chr.19:48847866 - 48986483 on Build GRCh38	Loss	PPP1R15A GYS1 FTL NUCB1 BAX TULP2 DHDH PLEKHA4 NUCB1-AS1
nsv833855	Chr.19:48750098 - 48949781 on Build GRCh38	Loss	FGF21 PPP1R15A NUCB1 TULP2 BCAT2 HSD17B14 DHDH PLEKHA4 NUCB1-AS1 FUT1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
cell cycle arrest
aging
negative regulation of cell proliferation
negative regulation of peptidyl-threonine phosphorylation
negative regulation of protein processing
endoplasmic reticulum unfolded protein response
positive regulation of translational initiation in response to stress
negative regulation of phosphoprotein phosphatase activity
positive regulation of phosphoprotein phosphatase activity
cellular response to UV
response to endoplasmic reticulum stress
negative regulation of protein dephosphorylation
cellular response to drug
response to immobilization stress
regulation of translational initiation by eIF2 alpha dephosphorylation
response to cocaine
positive regulation of apoptotic process
regulation of angiogenesis
negative regulation of cell death
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
peptidyl-serine dephosphorylation
protein localization to endoplasmic reticulum
cellular response to antibiotic
cellular response to carbohydrate stimulus
cellular response to methyl methanesulfonate
cellular response to calcium ion starvation
response to environmental enrichment
cellular response to oxygen-glucose deprivation
positive regulation of peptidyl-serine dephosphorylation
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
cellular response to desipramine
cellular response to cordycepin
cellular response to gold(3+)
cellular response to methamphetamine hydrochloride
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Function(s)

protein binding
protein phosphatase 1 binding
protein phosphatase type 1 regulator activity
protein kinase binding
protein phosphatase type 1 activator activity