Hs04022421_cn

• Gene Symbol: MED25
• Assay Reference Genome Location: Chr.19:49837270 on build GRCh38
• Cytoband: 19q13.33

Target Gene Details

• Entrez Gene ID: 81857
• Gene Name: mediator complex subunit 25
• Gene Aliases: ACID1, ARC92, BVSYS, CMT2B2, P78, PTOV2, TCBAP0758
• Location: Chr.19:49818279-49840384 on Build GRCh38
• Assay Gene Location: Within Intron 18

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
MED25	XM_011527353.1			XP_011525655.1
	AF283769.2			AAG15589.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv9739	Chr.19:47901840 - 50143063 on Build GRCh38	Gain+Loss	CD37 RPS11 FGF21 MED25 SNAR-A2 MIR4749 SIGLEC16 PTOV1-AS1 BAX SULT2B1 SNAR-A13 SPACA4 C19orf68 SYNGR4 LOC105372430 FLT3LG TEAD2 RPL18 MIR150 PRMT1 TBC1D17 SEC1P PRRG2 SNAR-D LMTK3 RPL13A FCGRT HRC SNORD35B FUZ GRWD1 NTN5 NUP62 NTF4 SLC17A7 DKKL1 DBP CARD8 MIR6799 KCNA7 SNORD33 FTL BSPH1 SNAR-C5 CCDC155 SNAR-A4 CA11 TSKS GFY RASIP1 CGB5 SNRNP70 SNAR-A14 FUT2 PLA2G4C VRK3 RRAS CCDC114 SNAR-C1 IL4I1 GYS1 SNAR-A3 SIGLEC11 LOC101059948 SLC6A16 SNAR-G2 LOC100287477 SCAF1 MIR5088 ZNF114 LHB EMP3 CGB2 PRR12 CPT1C SNORD34 SNAR-A5 SNAR-A6 SNAR-A12 ATF5 CABP5 KDELR1 TULP2 FAM83E RUVBL2 NOSIP SNAR-A11 NUCB1 FLJ26850 BCAT2 MIR4324 AP2A1 PNKP ELSPBP1 MIR4751 CGB3 PIH1D1 ALDH16A1 LIN7B GRIN2D CARD8-AS1 LIG1 RCN3 SNAR-G1 SNAR-B1 AKT1S1 LOC101928295 PLA2G4C-AS1 SNORD32A C19orf73 BCL2L12 SNAR-A9 SNAR-C4 SNAR-C2 ZNF473 PTOV1-AS2 MAMSTR SNAR-C3 LOC105447645 CGB1 PLEKHA4 SPHK2 IRF3 MIR6800 NUCB1-AS1 KCNJ14 MIR4750 PPFIA3 DHDH SNAR-A10 PTH2 ADM5 TRPM4 FUT1 CGB8 HSD17B14 CYTH2 SNAR-A7 MIR6798 SNAR-B2 PPP1R15A SNAR-A1 SNORD35A IZUMO1 TMEM143 PTOV1 CGB7 SNAR-A8
nsv470150	Chr.19:49618821 - 49856789 on Build GRCh38	Gain	TSKS BCL2L12 ADM5 MIR5088 MIR6799 PRMT1 PRR12 CPT1C AP2A1 PTOV1-AS2 MED25 RRAS MIR4749 PTOV1-AS1 FUZ IRF3 MIR6800 SCAF1 PTOV1
dgv53n68	Chr.19:49724393 - 49943224 on Build GRCh38	Loss	TSKS MIR6799 TBC1D17 AP2A1 PNKP MIR4751 PTOV1-AS2 MED25 ATF5 MIR4749 PTOV1-AS1 IL4I1 FUZ AKT1S1 MIR6800 MIR4750 PTOV1 NUP62
nsv953600	Chr.19:49555044 - 49938043 on Build GRCh38	Deletion	BCL2L12 MIR5088 MIR6799 PRR12 CPT1C PTOV1-AS2 MED25 ATF5 MIR4749 PTOV1-AS1 NOSIP IRF3 MIR6800 MIR4750 TSKS ADM5 PRMT1 TBC1D17 AP2A1 PNKP MIR4751 PRRG2 RRAS IL4I1 FUZ AKT1S1 SCAF1 PTOV1 NUP62
nsv1160655	Chr.19:49489110 - 49841830 on Build GRCh38	Deletion	BCL2L12 MIR5088 MIR6799 PRR12 CPT1C RPS11 SNORD33 SNORD34 MED25 PTOV1-AS1 NOSIP IRF3 MIR6800 TSKS ADM5 MIR150 PRMT1 AP2A1 PRRG2 RRAS RPL13A FCGRT SNORD35B FUZ RCN3 SNORD35A SCAF1 SNORD32A

More Information

Additional Information:

For this assay, SNP(s) [rs117280890] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

general transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
positive regulation of chromatin binding
positive regulation of transcription from RNA polymerase II promoter
negative regulation of fibroblast proliferation
positive regulation of cell cycle arrest
positive regulation of mediator complex assembly

Function(s)

protein binding
transcription factor binding
retinoic acid receptor binding
retinoid X receptor binding