Hs04024436_cn

• Gene Symbol: FSTL3
• Assay Reference Genome Location: Chr.19:677410 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 10272
• Gene Name: follistatin like 3
• Gene Aliases: FLRG, FSRP
• Location: Chr.19:676389-683392 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
FSTL3	NM_005860.2			NP_005851.1
	AK291958.1
	AK313341.1
	AY358917.1			AAQ89276.1
	BC005839.2			AAH05839.1
	BX439786.2
	U76702.1			AAC64321.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv578163	Chr.19:629303 - 682010 on Build GRCh38	Loss	POLRMT RNF126 FGF22 FSTL3
nsv428360	Chr.19:232069 - 702131 on Build GRCh38	Gain	CDC34 POLRMT TPGS1 HCN2 BSG SHC2 RNF126 MIER2 FGF22 ODF3L2 GZMM FSTL3 PLPP2 PRSS57 C2CD4C MADCAM1 THEG LOC101929060
dgv134n111	Chr.19:607984 - 967584 on Build GRCh38	Deletion	POLRMT KISS1R R3HDM4 LOC101928450 HCN2 RNF126 MISP FGF22 FSTL3 ARID3A PTBP1 PALM PRTN3 CFD ELANE MIR3187 PLPPR3 PRSS57 MED16 MIR4745 AZU1 RNU6-9
nsv577978	Chr.19:294526 - 782854 on Build GRCh38	Gain	CDC34 POLRMT TPGS1 LOC101928450 HCN2 BSG SHC2 RNF126 MISP MIER2 FGF22 ODF3L2 GZMM FSTL3 PALM PRSS57 C2CD4C MADCAM1 THEG LOC101929060
nsv953938	Chr.19:355801 - 1104501 on Build GRCh38	Deletion	CDC34 POLRMT SHC2 TMEM259 RNF126 MISP LOC105372235 FGF22 ODF3L2 FSTL3 ARHGAP45 PTBP1 PRSS57 MED16 MIR4745 AZU1 C2CD4C RNU6-9 MADCAM1 WDR18 KISS1R R3HDM4 TPGS1 GRIN3B LOC101928450 HCN2 BSG POLR2E GZMM ABCA7 ARID3A GPX4 CNN2 RNU6-2 PALM PRTN3 CFD ELANE MIR3187 PLPPR3 THEG
nsv470101	Chr.19:401714 - 1008505 on Build GRCh38	Loss	CDC34 POLRMT SHC2 RNF126 MISP LOC105372235 FGF22 ODF3L2 FSTL3 PTBP1 PRSS57 MED16 MIR4745 AZU1 C2CD4C RNU6-9 MADCAM1 WDR18 KISS1R R3HDM4 TPGS1 GRIN3B LOC101928450 HCN2 BSG GZMM ARID3A PALM PRTN3 CFD ELANE MIR3187 PLPPR3

More Information

Additional Information:

For this assay, SNP(s) [rs151127711] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

extracellular matrix glycoprotein

Gene Ontology Categories:

Process(es)

ossification
kidney development
hematopoietic progenitor cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
male gonad development
positive regulation of cell-cell adhesion
lung development
adrenal gland development
negative regulation of BMP signaling pathway
negative regulation of activin receptor signaling pathway
negative regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to metal ion
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Function(s)

fibronectin binding
protein binding
activin binding