Hs04026755_cn

• Gene Symbol: PPP1R15A
• Assay Reference Genome Location: Chr.19:48875335 on build GRCh38
• Cytoband: 19q13.33

Target Gene Details

• Entrez Gene ID: 23645
• Gene Name: protein phosphatase 1 regulatory subunit 15A
• Gene Aliases: GADD34
• Location: Chr.19:48872392-48876062 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PPP1R15A	NM_014330.3			NP_055145.3
	AK001361.1			BAA91649.1
	AK225632.1
	AK296668.1
	AK297615.1
	AK298765.1
	BC003067.2			AAH03067.1
	CR457259.1			CAG33540.1
	U83981.1			AAC25631.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv9739	Chr.19:47901840 - 50143063 on Build GRCh38	Gain+Loss	GRIN2D GYS1 FCGRT CPT1C LMTK3 DBP C19orf68 RPL18 PTH2 RUVBL2 PLA2G4C CGB8 PRRG2 CGB3 MIR4750 MIR6799 GRWD1 CCDC155 SNAR-A5 CGB1 TRPM4 BAX FUT1 SNAR-A1 LIN7B TMEM143 SNORD35A BCAT2 SIGLEC16 TULP2 ALDH16A1 SNAR-A2 RPS11 PTOV1-AS2 SNAR-D EMP3 SNAR-A11 RPL13A SNAR-C3 IZUMO1 HRC SNORD33 IRF3 FUZ CARD8 ATF5 KDELR1 RCN3 TBC1D17 PRMT1 CGB7 SNORD34 PPP1R15A SNAR-G1 FTL CARD8-AS1 LOC100287477 TSKS PTOV1 SPHK2 MIR6798 FLJ26850 FAM83E FUT2 AP2A1 LIG1 SNAR-A12 LHB SIGLEC11 CCDC114 SNAR-C1 NUCB1-AS1 SCAF1 MIR4324 SNRNP70 SNAR-A13 MIR5088 TEAD2 PLA2G4C-AS1 SNAR-A7 BCL2L12 SNAR-B2 CGB2 SNAR-C4 SNAR-A6 PIH1D1 GFY SNAR-G2 LOC101059948 SLC6A16 CA11 SLC17A7 SNAR-B1 SYNGR4 MIR4751 SNAR-C2 PPFIA3 ELSPBP1 SNORD32A SNAR-A14 CGB5 CYTH2 NUP62 RRAS KCNJ14 LOC105447645 NOSIP NUCB1 MED25 SNAR-A9 PRR12 MAMSTR VRK3 NTN5 AKT1S1 SEC1P NTF4 SNORD35B HSD17B14 SULT2B1 BSPH1 SNAR-A10 SNAR-C5 ZNF114 DKKL1 CABP5 SNAR-A4 ADM5 DHDH CD37 SPACA4 RASIP1 FLT3LG PTOV1-AS1 LOC101928295 SNAR-A8 MIR150 PNKP LOC105372430 PLEKHA4 FGF21 MIR6800 SNAR-A3 MIR4749 ZNF473 C19orf73 IL4I1 KCNA7
nsv470148	Chr.19:48865586 - 48906934 on Build GRCh38	Gain	PLEKHA4 TULP2 PPP1R15A NUCB1
nsv833856	Chr.19:48847866 - 48986483 on Build GRCh38	Loss	PLEKHA4 GYS1 TULP2 DHDH NUCB1-AS1 PPP1R15A FTL NUCB1 BAX
nsv833855	Chr.19:48750098 - 48949781 on Build GRCh38	Loss	PLEKHA4 BCAT2 FGF21 TULP2 DHDH NUCB1-AS1 PPP1R15A HSD17B14 NUCB1 FUT1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
cell cycle arrest
aging
negative regulation of cell proliferation
negative regulation of peptidyl-threonine phosphorylation
negative regulation of protein processing
endoplasmic reticulum unfolded protein response
positive regulation of translational initiation in response to stress
negative regulation of phosphoprotein phosphatase activity
positive regulation of phosphoprotein phosphatase activity
cellular response to UV
response to endoplasmic reticulum stress
negative regulation of protein dephosphorylation
cellular response to drug
response to immobilization stress
regulation of translational initiation by eIF2 alpha dephosphorylation
response to cocaine
positive regulation of apoptotic process
regulation of angiogenesis
negative regulation of cell death
regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
peptidyl-serine dephosphorylation
protein localization to endoplasmic reticulum
cellular response to antibiotic
cellular response to carbohydrate stimulus
cellular response to methyl methanesulfonate
cellular response to calcium ion starvation
response to environmental enrichment
cellular response to oxygen-glucose deprivation
positive regulation of peptidyl-serine dephosphorylation
negative regulation of PERK-mediated unfolded protein response
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation
cellular response to desipramine
cellular response to cordycepin
cellular response to gold(3+)
cellular response to methamphetamine hydrochloride
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Function(s)

protein binding
protein phosphatase 1 binding
protein phosphatase type 1 regulator activity
protein kinase binding
protein phosphatase type 1 activator activity