Hs04039553_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63533002 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK124082.1	1	372
	AK301364.1
	AK315232.1
	BC035843.1			AAH35843.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	MIR3196 BIRC7 EEF1A2 YTHDF1 MIR124-3 SRMS PTK6 COL20A1 KCNQ2 ARFGAP1 CHRNA4 LOC100130587 LOC100130152 PPDPF FNDC11 LOC102723788 HELZ2 MIR4326 NKAIN4 LOC107985425 FLJ16779
nsv521734	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	FNDC11 SRMS PTK6 HELZ2
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	EEF1A2 YTHDF1 OGFR HAR1A SRMS PTK6 KCNQ2 LOC63930 LOC100130587 FNDC11 LINC00659 MIR4326 LINC01056 MIR3196 DPH3P1 BIRC7 LINC00029 MIR124-3 TCFL5 BHLHE23 COL20A1 DIDO1 ARFGAP1 CHRNA4 OGFR-AS1 LOC100130152 GMEB2 PPDPF LOC102723788 HAR1B GID8 SLC17A9 HELZ2 NKAIN4 MRGBP LOC107985425 COL9A3 LOC107985428 FLJ16779
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	PPDPF FNDC11 EEF1A2 SRMS PTK6 KCNQ2
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	EEF1A2 SRMS PTK6 RTEL1-TNFRSF6B LIME1 SLC2A4RG STMN3 GMEB2 LOC100505771 PPDPF FNDC11 HELZ2 ARFRP1 ZGPAT TNFRSF6B ZBTB46 RTEL1
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	GMEB2 PPDPF FNDC11 EEF1A2 SRMS PTK6 HELZ2 KCNQ2
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	PPDPF EEF1A2 SRMS PTK6
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	EEF1A2 SRMS PTK6 KCNQ2 RTEL1-TNFRSF6B LIME1 SLC2A4RG STMN3 GMEB2 LOC100505771 PPDPF FNDC11 HELZ2 ARFRP1 ZGPAT TNFRSF6B ZBTB46 RTEL1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding