Hs04039553_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63533002 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK124082.1	1	372
	AK301364.1
	AK315232.1
	BC035843.1			AAH35843.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	SRMS NKAIN4 FLJ16779 LOC107985425 KCNQ2 LOC100130587 MIR124-3 ARFGAP1 COL20A1 YTHDF1 LOC100130152 FNDC11 MIR4326 CHRNA4 LOC102723788 PTK6 PPDPF BIRC7 EEF1A2 HELZ2 MIR3196
dgv521n27	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	SRMS FNDC11 PTK6 HELZ2
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	DIDO1 SRMS FLJ16779 GID8 LOC100130587 COL9A3 SLC17A9 MIR124-3 ARFGAP1 HAR1A TCFL5 LOC100130152 OGFR CHRNA4 PTK6 LOC63930 EEF1A2 MIR3196 LINC00659 NKAIN4 LOC107985425 KCNQ2 LINC00029 LINC01056 DPH3P1 LOC107985428 MRGBP COL20A1 YTHDF1 GMEB2 FNDC11 MIR4326 BHLHE23 LOC102723788 HAR1B PPDPF BIRC7 HELZ2 OGFR-AS1
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	SRMS LOC100505771 RTEL1-TNFRSF6B STMN3 SLC2A4RG ZGPAT TNFRSF6B GMEB2 FNDC11 ARFRP1 PTK6 PPDPF LIME1 RTEL1 EEF1A2 HELZ2 ZBTB46
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	SRMS FNDC11 KCNQ2 PTK6 PPDPF EEF1A2
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	SRMS GMEB2 FNDC11 KCNQ2 PTK6 PPDPF EEF1A2 HELZ2
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	SRMS PTK6 PPDPF EEF1A2
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	SRMS KCNQ2 LOC100505771 RTEL1-TNFRSF6B STMN3 SLC2A4RG ZGPAT TNFRSF6B GMEB2 FNDC11 ARFRP1 PTK6 PPDPF LIME1 RTEL1 EEF1A2 HELZ2 ZBTB46

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding