Hs04047625_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63532033 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK124082.1
	AK301364.1
	AK315232.1
	BC035843.1			AAH35843.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	MIR4326 SRMS HELZ2 KCNQ2 MIR124-3 FNDC11 EEF1A2 LOC107985425 BIRC7 LOC100130587 CHRNA4 ARFGAP1 MIR3196 PTK6 YTHDF1 LOC102723788 PPDPF LOC100130152 COL20A1 FLJ16779 NKAIN4
nsv521734	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	SRMS PTK6 HELZ2 FNDC11
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	LOC107985428 DIDO1 FNDC11 EEF1A2 BIRC7 MRGBP LOC100130587 OGFR MIR3196 PPDPF DPH3P1 LOC100130152 COL20A1 BHLHE23 FLJ16779 NKAIN4 LINC00029 MIR4326 SRMS OGFR-AS1 HAR1B GID8 HELZ2 GMEB2 KCNQ2 MIR124-3 TCFL5 LOC107985425 SLC17A9 CHRNA4 HAR1A ARFGAP1 LINC01056 PTK6 YTHDF1 LOC102723788 LINC00659 COL9A3 LOC63930
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	LOC100505771 SRMS HELZ2 SLC2A4RG GMEB2 RTEL1 TNFRSF6B FNDC11 EEF1A2 ZBTB46 STMN3 LIME1 ZGPAT PTK6 PPDPF RTEL1-TNFRSF6B ARFRP1
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	SRMS PTK6 PPDPF KCNQ2 FNDC11 EEF1A2
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	SRMS PTK6 HELZ2 PPDPF GMEB2 KCNQ2 FNDC11 EEF1A2
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	SRMS PTK6 PPDPF EEF1A2
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	LOC100505771 SRMS HELZ2 SLC2A4RG GMEB2 KCNQ2 RTEL1 TNFRSF6B FNDC11 EEF1A2 ZBTB46 STMN3 LIME1 ZGPAT PTK6 PPDPF RTEL1-TNFRSF6B ARFRP1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding