Hs04051017_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63534647 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK301364.1
	AK301691.1	2	675
	AK315232.1
	BC035843.1			AAH35843.1
	DA762278.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	ARFGAP1 MIR3196 HELZ2 FLJ16779 LOC100130587 KCNQ2 MIR124-3 LOC102723788 LOC107985425 PTK6 SRMS EEF1A2 LOC100130152 MIR4326 BIRC7 CHRNA4 PPDPF FNDC11 YTHDF1 NKAIN4 COL20A1
nsv521734	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	SRMS HELZ2 FNDC11 PTK6
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	MIR3196 FLJ16779 SLC17A9 LOC102723788 HAR1B LINC01056 LINC00029 SRMS MIR4326 BIRC7 CHRNA4 PPDPF FNDC11 NKAIN4 MRGBP OGFR-AS1 HAR1A LINC00659 DPH3P1 ARFGAP1 HELZ2 LOC100130587 KCNQ2 MIR124-3 GID8 LOC107985428 LOC107985425 TCFL5 LOC63930 PTK6 EEF1A2 COL9A3 LOC100130152 GMEB2 OGFR YTHDF1 DIDO1 BHLHE23 COL20A1
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	RTEL1 LOC100505771 ZBTB46 HELZ2 RTEL1-TNFRSF6B STMN3 PTK6 ARFRP1 SRMS EEF1A2 SLC2A4RG TNFRSF6B GMEB2 PPDPF FNDC11 LIME1 ZGPAT
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	SRMS EEF1A2 KCNQ2 PPDPF FNDC11 PTK6
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	SRMS EEF1A2 HELZ2 GMEB2 KCNQ2 PPDPF FNDC11 PTK6
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	SRMS EEF1A2 PPDPF PTK6
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	RTEL1 LOC100505771 ZBTB46 HELZ2 RTEL1-TNFRSF6B KCNQ2 STMN3 PTK6 ARFRP1 SRMS EEF1A2 SLC2A4RG TNFRSF6B GMEB2 PPDPF FNDC11 LIME1 ZGPAT

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding