Hs04051017_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63534647 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK301364.1
	AK301691.1	2	675
	AK315232.1
	BC035843.1			AAH35843.1
	DA762278.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	MIR3196 LOC100130587 LOC100130152 LOC102723788 COL20A1 YTHDF1 BIRC7 PTK6 SRMS FLJ16779 HELZ2 EEF1A2 LOC107985425 MIR124-3 CHRNA4 FNDC11 KCNQ2 PPDPF ARFGAP1 NKAIN4 MIR4326
dgv521n27	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	FNDC11 PTK6 SRMS HELZ2
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	LOC100130152 LINC00659 LOC102723788 COL20A1 YTHDF1 DIDO1 PTK6 MRGBP SRMS DPH3P1 LOC107985428 EEF1A2 OGFR-AS1 LOC63930 LOC107985425 MIR124-3 FNDC11 KCNQ2 GID8 HAR1A TCFL5 OGFR ARFGAP1 BHLHE23 NKAIN4 COL9A3 MIR3196 GMEB2 LOC100130587 SLC17A9 BIRC7 HAR1B FLJ16779 HELZ2 CHRNA4 PPDPF LINC01056 LINC00029 MIR4326
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	EEF1A2 FNDC11 KCNQ2 PPDPF PTK6 SRMS
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	LIME1 GMEB2 ZBTB46 ZGPAT LOC100505771 PTK6 RTEL1-TNFRSF6B SRMS HELZ2 EEF1A2 TNFRSF6B FNDC11 RTEL1 STMN3 PPDPF ARFRP1 SLC2A4RG
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	EEF1A2 GMEB2 FNDC11 KCNQ2 PPDPF PTK6 SRMS HELZ2
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	EEF1A2 PPDPF PTK6 SRMS
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	LIME1 GMEB2 ZBTB46 ZGPAT LOC100505771 PTK6 RTEL1-TNFRSF6B SRMS HELZ2 EEF1A2 TNFRSF6B FNDC11 KCNQ2 RTEL1 STMN3 PPDPF ARFRP1 SLC2A4RG

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding