Hs04051668_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63535178 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK301364.1
	AK301691.1
	AK315232.1
	BC035843.1			AAH35843.1
	DA762278.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	MIR3196 NKAIN4 PPDPF MIR4326 BIRC7 EEF1A2 YTHDF1 LOC100130152 LOC100130587 KCNQ2 SRMS PTK6 LOC107985425 ARFGAP1 FNDC11 FLJ16779 MIR124-3 CHRNA4 LOC102723788 COL20A1 HELZ2
dgv521n27	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	FNDC11 SRMS HELZ2 PTK6
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	MIR3196 BIRC7 EEF1A2 YTHDF1 KCNQ2 OGFR-AS1 COL9A3 PTK6 LOC107985425 DIDO1 DPH3P1 FNDC11 LINC00029 OGFR FLJ16779 HAR1A LINC00659 LOC102723788 HAR1B COL20A1 HELZ2 LINC01056 NKAIN4 PPDPF MIR4326 LOC63930 SLC17A9 LOC100130152 LOC100130587 LOC107985428 SRMS GMEB2 ARFGAP1 GID8 BHLHE23 TCFL5 MIR124-3 CHRNA4 MRGBP
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	PPDPF FNDC11 EEF1A2 KCNQ2 SRMS PTK6
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	ARFRP1 ZGPAT PPDPF EEF1A2 RTEL1 ZBTB46 SRMS RTEL1-TNFRSF6B TNFRSF6B PTK6 GMEB2 LOC100505771 STMN3 FNDC11 LIME1 HELZ2 SLC2A4RG
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	PPDPF FNDC11 EEF1A2 KCNQ2 SRMS HELZ2 PTK6 GMEB2
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	PPDPF EEF1A2 SRMS PTK6
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	ARFRP1 ZGPAT PPDPF EEF1A2 RTEL1 ZBTB46 KCNQ2 SRMS RTEL1-TNFRSF6B TNFRSF6B PTK6 GMEB2 LOC100505771 STMN3 FNDC11 LIME1 HELZ2 SLC2A4RG

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding