Hs04053813_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63535584 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK301364.1
	AK301691.1
	AK315232.1
	BC035843.1			AAH35843.1
	DA762278.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	BIRC7 EEF1A2 MIR124-3 YTHDF1 FLJ16779 LOC100130152 HELZ2 MIR3196 MIR4326 KCNQ2 LOC102723788 COL20A1 LOC100130587 NKAIN4 PPDPF FNDC11 PTK6 SRMS ARFGAP1 LOC107985425 CHRNA4
nsv521734	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	FNDC11 PTK6 HELZ2 SRMS
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	MRGBP BIRC7 MIR124-3 FLJ16779 LOC100130152 OGFR-AS1 COL9A3 MIR4326 GID8 LOC100130587 NKAIN4 HAR1A OGFR SRMS DIDO1 ARFGAP1 GMEB2 EEF1A2 DPH3P1 LOC63930 YTHDF1 TCFL5 HELZ2 SLC17A9 LOC107985428 MIR3196 KCNQ2 LOC102723788 COL20A1 LINC01056 LINC00659 PPDPF FNDC11 PTK6 BHLHE23 LINC00029 LOC107985425 HAR1B CHRNA4
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	GMEB2 EEF1A2 RTEL1-TNFRSF6B LOC100505771 LIME1 HELZ2 STMN3 RTEL1 ARFRP1 ZGPAT TNFRSF6B SLC2A4RG PPDPF FNDC11 PTK6 SRMS ZBTB46
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	EEF1A2 KCNQ2 PPDPF FNDC11 PTK6 SRMS
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	GMEB2 EEF1A2 KCNQ2 PPDPF FNDC11 PTK6 HELZ2 SRMS
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	EEF1A2 PPDPF PTK6 SRMS
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	GMEB2 EEF1A2 RTEL1-TNFRSF6B LOC100505771 LIME1 HELZ2 STMN3 RTEL1 ARFRP1 ZGPAT TNFRSF6B KCNQ2 SLC2A4RG PPDPF FNDC11 PTK6 SRMS ZBTB46

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding