Hs04057071_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63531717 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK124082.1
	AK301364.1
	AK315232.1
	BC035843.1			AAH35843.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	YTHDF1 LOC100130152 FLJ16779 ARFGAP1 COL20A1 PPDPF KCNQ2 MIR124-3 LOC100130587 MIR4326 EEF1A2 LOC102723788 CHRNA4 LOC107985425 MIR3196 NKAIN4 FNDC11 PTK6 SRMS BIRC7 HELZ2
nsv521734	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	FNDC11 PTK6 SRMS HELZ2
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	FLJ16779 HAR1B LINC01056 MIR124-3 BHLHE23 MIR4326 DPH3P1 EEF1A2 LOC102723788 LINC00029 LINC00659 MRGBP MIR3196 NKAIN4 DIDO1 PTK6 BIRC7 OGFR HELZ2 YTHDF1 LOC100130152 HAR1A ARFGAP1 COL20A1 PPDPF KCNQ2 GID8 LOC100130587 SLC17A9 OGFR-AS1 LOC107985428 CHRNA4 LOC107985425 COL9A3 FNDC11 TCFL5 SRMS GMEB2 LOC63930
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	LIME1 STMN3 RTEL1 PPDPF ARFRP1 LOC100505771 ZBTB46 EEF1A2 RTEL1-TNFRSF6B FNDC11 TNFRSF6B PTK6 ZGPAT SRMS GMEB2 HELZ2 SLC2A4RG
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	PPDPF KCNQ2 FNDC11 PTK6 SRMS EEF1A2
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	PPDPF KCNQ2 FNDC11 PTK6 SRMS GMEB2 HELZ2 EEF1A2
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	PPDPF PTK6 SRMS EEF1A2
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	LIME1 STMN3 RTEL1 PPDPF KCNQ2 ARFRP1 LOC100505771 ZBTB46 EEF1A2 RTEL1-TNFRSF6B FNDC11 TNFRSF6B PTK6 ZGPAT SRMS GMEB2 HELZ2 SLC2A4RG

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding