Hs04057071_cn

• Gene Symbol: PTK6
• Assay Reference Genome Location: Chr.20:63531717 on build GRCh38
• Cytoband: 20q13.33

Target Gene Details

• Entrez Gene ID: 5753
• Gene Name: protein tyrosine kinase 6
• Gene Aliases: BRK
• Location: Chr.20:63528413-63537370 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PTK6	NM_001256358.1			NP_001243287.1
	NM_005975.3			NP_005966.1
	XM_017027982.1			XP_016883471.1
	AK124082.1
	AK301364.1
	AK315232.1
	BC035843.1			AAH35843.1
	X78549.1			CAA55295.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv953306	Chr.20:63151949 - 63571247 on Build GRCh38	Deletion	YTHDF1 FLJ16779 FNDC11 LOC107985425 MIR124-3 PTK6 HELZ2 LOC100130587 COL20A1 MIR3196 SRMS BIRC7 MIR4326 LOC102723788 EEF1A2 PPDPF CHRNA4 KCNQ2 ARFGAP1 NKAIN4 LOC100130152
dgv521n27	Chr.20:63522433 - 63566995 on Build GRCh38	Loss	FNDC11 PTK6 HELZ2 SRMS
nsv9825	Chr.20:62775470 - 63601330 on Build GRCh38	Gain	FLJ16779 LOC107985425 PTK6 LOC100130587 MRGBP MIR3196 HAR1A BIRC7 OGFR-AS1 MIR4326 LOC102723788 GMEB2 PPDPF CHRNA4 KCNQ2 ARFGAP1 DIDO1 LINC00659 YTHDF1 FNDC11 MIR124-3 HELZ2 COL20A1 DPH3P1 TCFL5 OGFR SRMS LINC01056 COL9A3 LOC63930 HAR1B EEF1A2 LOC107985428 BHLHE23 NKAIN4 LINC00029 GID8 SLC17A9 LOC100130152
nsv834033	Chr.20:63421436 - 63554987 on Build GRCh38	Gain	FNDC11 EEF1A2 PPDPF PTK6 KCNQ2 SRMS
nsv470563	Chr.20:63486715 - 63793308 on Build GRCh38	Loss	FNDC11 LOC100505771 LIME1 PTK6 HELZ2 SRMS ZBTB46 TNFRSF6B EEF1A2 GMEB2 PPDPF ZGPAT ARFRP1 STMN3 RTEL1 RTEL1-TNFRSF6B SLC2A4RG
nsv834034	Chr.20:63462825 - 63625901 on Build GRCh38	Loss	FNDC11 EEF1A2 GMEB2 PPDPF PTK6 HELZ2 KCNQ2 SRMS
nsv586569	Chr.20:63496168 - 63548764 on Build GRCh38	Loss	EEF1A2 PPDPF PTK6 SRMS
esv2758806	Chr.20:63470996 - 63745014 on Build GRCh38	Gain+Loss	FNDC11 LOC100505771 LIME1 PTK6 HELZ2 SRMS ZBTB46 TNFRSF6B EEF1A2 GMEB2 PPDPF KCNQ2 ZGPAT ARFRP1 STMN3 RTEL1 RTEL1-TNFRSF6B SLC2A4RG

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protein-binding activity modulator, scaffold/adaptor protein

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
negative regulation of signal transduction
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine autophosphorylation
ERBB2 signaling pathway
regulation of cell proliferation
tyrosine phosphorylation of Stat3 protein
tyrosine phosphorylation of Stat5 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
innate immune response
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of cell cycle
negative regulation of growth
protein autophosphorylation
intestinal epithelial cell differentiation
negative regulation of protein tyrosine kinase activity
cellular response to retinoic acid

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
identical protein binding