Hs04090450_cn

• Gene Symbol: TXNRD2
• Assay Reference Genome Location: Chr.22:19876535 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 10587
• Gene Name: thioredoxin reductase 2
• Gene Aliases: SELZ, TR, TR-BETA, TR3, TRXR2
• Location: Chr.22:19875518-19941992 on Build GRCh38
• Assay Gene Location: Within Intron 18

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TXNRD2	NM_006440.4			NP_006431.2
	AB019694.1			BAA77601.2
	AB019695.1			BAA77602.2
	AB209724.1			BAD92961.1
	AF044212.1			AAD25167.1
	AF106697.1			AAD19597.1
	AF166126.1			AAF21431.1
	AF166127.1			AAF21432.1
	AF171054.1			AAD51324.1
	AF201385.1	17	2142	AAG47635.1
	AK094698.1	5	1689
	AK097708.1
	BC007489.2			AAH07489.3
	BC117354.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv834129	Chr.22:19705617 - 19919068 on Build GRCh38	Loss	C22orf29 GNB1L SEPT5 SEPT5-GP1BB TBX1 TXNRD2 GP1BB
esv3893434	Chr.22:19470889 - 20343372 on Build GRCh38	Gain	RANBP1 LINC00896 CDC45 LOC101927859 LINC00895 RTN4R MIR1286 MIR6816 TANGO2 C22orf29 MIR1306 LOC284865 GNB1L CCDC188 DGCR8 TRMT2A SEPT5-GP1BB COMT ZDHHC8 ARVCF DGCR6L TXNRD2 GP1BB UFD1L MIR4761 MIR3618 TBX1 CLDN5 MIR185 SEPT5 LOC440792
nsv828939	Chr.22:19696032 - 20324465 on Build GRCh38	Loss	RANBP1 LINC00896 RTN4R MIR1286 MIR6816 TANGO2 C22orf29 MIR1306 LOC284865 GNB1L CCDC188 DGCR8 TRMT2A SEPT5-GP1BB COMT ZDHHC8 ARVCF DGCR6L TXNRD2 GP1BB MIR4761 MIR3618 TBX1 MIR185 SEPT5 LOC440792
nsv828938	Chr.22:19691069 - 20324465 on Build GRCh38	Gain	RANBP1 LINC00896 RTN4R MIR1286 MIR6816 TANGO2 C22orf29 MIR1306 LOC284865 GNB1L CCDC188 DGCR8 TRMT2A SEPT5-GP1BB COMT ZDHHC8 ARVCF DGCR6L TXNRD2 GP1BB MIR4761 MIR3618 TBX1 MIR185 SEPT5 LOC440792
nsv515664	Chr.22:19873352 - 19892114 on Build GRCh38	Loss	TXNRD2
nsv834130	Chr.22:19837923 - 19940567 on Build GRCh38	Loss	C22orf29 GNB1L TXNRD2
esv3568260	Chr.22:19777375 - 19881883 on Build GRCh38	Loss	C22orf29 GNB1L TBX1 TXNRD2
esv3647279	Chr.22:19719848 - 19878980 on Build GRCh38	Gain	C22orf29 GNB1L SEPT5 SEPT5-GP1BB TBX1 TXNRD2 GP1BB
nsv953025	Chr.22:19869078 - 19937977 on Build GRCh38	Deletion	TXNRD2
dgv7983n54	Chr.22:19762002 - 20321870 on Build GRCh38	Gain	RANBP1 LINC00896 MIR4761 MIR3618 RTN4R TBX1 MIR1286 MIR185 MIR6816 TANGO2 C22orf29 MIR1306 LOC284865 GNB1L CCDC188 DGCR8 TRMT2A COMT ZDHHC8 ARVCF LOC440792 DGCR6L TXNRD2
esv3575418	Chr.22:18161776 - 19963846 on Build GRCh38	Gain	LOC100996432 USP18 LOC642643 DGCR5 FAM230A CDC45 TMEM191B LINC01311 LINC00895 C22orf39 PI4KAP1 CLTCL1 C22orf29 MRPL40 SLC25A1 GNB1L DGCR11 GSC2 SEPT5-GP1BB LOC729461 COMT DGCR10 LOC100996415 DGCR9 TXNRD2 GP1BB DGCR14 UFD1L HIRA MIR4761 LOC100996401 DGCR2 DGCR6 GGT3P RIMBP3 TBX1 CLDN5 TSSK2 SEPT5 PRODH LOC102725072

More Information

Additional Information:

For this assay, SNP(s) [rs73877383] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

reductase

Gene Ontology Categories:

Process(es)

response to reactive oxygen species
response to oxygen radical
cell redox homeostasis
oxidation-reduction process
cellular oxidant detoxification

Function(s)

thioredoxin-disulfide reductase activity
protein binding
flavin adenine dinucleotide binding