Hs04091056_cn

• Gene Symbol: DGCR8
• Assay Reference Genome Location: Chr.22:20088423 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 54487
• Gene Name: DGCR8 microprocessor complex subunit
• Gene Aliases: C22orf12, DGCRK6, Gy1, pasha
• Location: Chr.22:20080232-20111877 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DGCR8	NM_001190326.1			NP_001177255.1
	NM_022720.6			NP_073557.3
	AK025539.1			BAB15165.1
	AK222796.1			BAD96516.1
	AK313357.1
	BC009323.2			AAH09323.2
	BC009984.2			AAH09984.1
	BC078147.1			AAH78147.1
	BX649187.1			CAE46205.2
	CR456356.1			CAG30242.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv726n67	Chr.22:20070444 - 20324465 on Build GRCh38	Gain	MIR1286 CCDC188 ZDHHC8 DGCR6L MIR6816 LINC00896 TRMT2A DGCR8 MIR1306 MIR3618 RANBP1 LOC440792 RTN4R LOC284865
esv3893434	Chr.22:19470889 - 20343372 on Build GRCh38	Gain	TXNRD2 ARVCF TANGO2 MIR185 MIR4761 GNB1L MIR6816 LINC00895 LINC00896 TRMT2A LOC440792 LOC284865 MIR1286 COMT CCDC188 CLDN5 ZDHHC8 GP1BB DGCR6L TBX1 SEPT5 LOC101927859 DGCR8 UFD1L MIR1306 MIR3618 RANBP1 RTN4R CDC45 SEPT5-GP1BB C22orf29
esv3647284	Chr.22:19985583 - 20137122 on Build GRCh38	Gain	ZDHHC8 ARVCF TRMT2A DGCR8 MIR1306 MIR3618 RANBP1 TANGO2 MIR185 MIR6816
nsv828938	Chr.22:19691069 - 20324465 on Build GRCh38	Gain	TXNRD2 ARVCF TANGO2 MIR185 MIR4761 GNB1L MIR6816 LINC00896 TRMT2A LOC440792 LOC284865 MIR1286 COMT CCDC188 ZDHHC8 GP1BB DGCR6L TBX1 SEPT5 DGCR8 MIR1306 MIR3618 RANBP1 RTN4R SEPT5-GP1BB C22orf29
nsv828939	Chr.22:19696032 - 20324465 on Build GRCh38	Loss	TXNRD2 ARVCF TANGO2 MIR185 MIR4761 GNB1L MIR6816 LINC00896 TRMT2A LOC440792 LOC284865 MIR1286 COMT CCDC188 ZDHHC8 GP1BB DGCR6L TBX1 SEPT5 DGCR8 MIR1306 MIR3618 RANBP1 RTN4R SEPT5-GP1BB C22orf29
esv2758825	Chr.22:20038970 - 20321924 on Build GRCh38	Loss	MIR1286 CCDC188 ZDHHC8 TANGO2 DGCR6L MIR6816 LINC00896 TRMT2A DGCR8 MIR1306 MIR3618 RANBP1 LOC440792 RTN4R LOC284865
dgv4480n100	Chr.22:20069620 - 20262667 on Build GRCh38	Gain	MIR1286 CCDC188 ZDHHC8 LINC00896 TRMT2A DGCR8 MIR1306 MIR3618 RANBP1 RTN4R LOC284865 MIR6816
dgv1291e212	Chr.22:20088151 - 20092050 on Build GRCh38	Loss	DGCR8
nsv471183	Chr.22:20018517 - 20319470 on Build GRCh38	Loss	MIR1286 CCDC188 ZDHHC8 TANGO2 MIR185 DGCR6L MIR6816 LINC00896 TRMT2A DGCR8 MIR1306 MIR3618 RANBP1 LOC440792 RTN4R LOC284865
dgv7983n54	Chr.22:19762002 - 20321870 on Build GRCh38	Gain	TXNRD2 MIR1286 COMT CCDC188 ZDHHC8 ARVCF TANGO2 MIR185 DGCR6L MIR4761 GNB1L TBX1 MIR6816 LINC00896 TRMT2A DGCR8 MIR1306 MIR3618 RANBP1 LOC440792 RTN4R LOC284865 C22orf29
nsv834133	Chr.22:20029363 - 20176708 on Build GRCh38	Loss	CCDC188 ZDHHC8 TRMT2A DGCR8 MIR1306 MIR3618 RANBP1 TANGO2 MIR185 MIR6816
nsv953027	Chr.22:20085378 - 20303977 on Build GRCh38	Deletion	MIR1286 CCDC188 ZDHHC8 MIR6816 LINC00896 TRMT2A DGCR8 MIR1306 MIR3618 RANBP1 LOC440792 RTN4R LOC284865

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, RNA processing factor, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

gene silencing by RNA
primary miRNA processing
regulation of stem cell proliferation
RNA phosphodiester bond hydrolysis, endonucleolytic

Function(s)

double-stranded RNA binding
ribonuclease III activity
protein binding
heme binding
protein homodimerization activity
metal ion binding
primary miRNA binding