Hs04094247_cn

• Gene Symbol: DGCR8
• Assay Reference Genome Location: Chr.22:20084527 on build GRCh38
• Cytoband: 22q11.21

Target Gene Details

• Entrez Gene ID: 54487
• Gene Name: DGCR8 microprocessor complex subunit
• Gene Aliases: C22orf12, DGCRK6, Gy1, pasha
• Location: Chr.22:20080232-20111877 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DGCR8	NM_001190326.1			NP_001177255.1
	NM_022720.6			NP_073557.3
	AK313357.1
	BC009984.2			AAH09984.1
	BQ227899.1
	DA433651.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv726n67	Chr.22:20070444 - 20324465 on Build GRCh38	Gain	CCDC188 MIR3618 MIR1286 LOC284865 DGCR6L TRMT2A MIR6816 MIR1306 RANBP1 DGCR8 RTN4R ZDHHC8 LINC00896 LOC440792
esv3893434	Chr.22:19470889 - 20343372 on Build GRCh38	Gain	CCDC188 UFD1L LOC284865 DGCR6L MIR6816 CDC45 C22orf29 SEPT5-GP1BB ARVCF RANBP1 DGCR8 RTN4R TBX1 GNB1L COMT CLDN5 MIR3618 MIR1286 LOC101927859 LINC00895 GP1BB TRMT2A MIR1306 TXNRD2 ZDHHC8 MIR4761 SEPT5 TANGO2 LINC00896 MIR185 LOC440792
esv3647284	Chr.22:19985583 - 20137122 on Build GRCh38	Gain	ARVCF RANBP1 DGCR8 MIR3618 ZDHHC8 TANGO2 TRMT2A MIR185 MIR6816 MIR1306
nsv828938	Chr.22:19691069 - 20324465 on Build GRCh38	Gain	CCDC188 LOC284865 DGCR6L MIR6816 C22orf29 SEPT5-GP1BB ARVCF RANBP1 DGCR8 RTN4R TBX1 GNB1L COMT MIR3618 MIR1286 GP1BB TRMT2A MIR1306 TXNRD2 ZDHHC8 MIR4761 SEPT5 TANGO2 LINC00896 MIR185 LOC440792
nsv828939	Chr.22:19696032 - 20324465 on Build GRCh38	Loss	CCDC188 LOC284865 DGCR6L MIR6816 C22orf29 SEPT5-GP1BB ARVCF RANBP1 DGCR8 RTN4R TBX1 GNB1L COMT MIR3618 MIR1286 GP1BB TRMT2A MIR1306 TXNRD2 ZDHHC8 MIR4761 SEPT5 TANGO2 LINC00896 MIR185 LOC440792
esv2758825	Chr.22:20038970 - 20321924 on Build GRCh38	Loss	CCDC188 MIR3618 MIR1286 LOC284865 DGCR6L TRMT2A MIR6816 MIR1306 RANBP1 DGCR8 RTN4R ZDHHC8 TANGO2 LINC00896 LOC440792
dgv4480n100	Chr.22:20069620 - 20262667 on Build GRCh38	Gain	CCDC188 RANBP1 DGCR8 MIR3618 RTN4R ZDHHC8 MIR1286 LOC284865 TRMT2A LINC00896 MIR6816 MIR1306
nsv471183	Chr.22:20018517 - 20319470 on Build GRCh38	Loss	CCDC188 MIR3618 MIR1286 LOC284865 DGCR6L TRMT2A MIR6816 MIR1306 RANBP1 DGCR8 RTN4R ZDHHC8 TANGO2 LINC00896 MIR185 LOC440792
dgv7983n54	Chr.22:19762002 - 20321870 on Build GRCh38	Gain	COMT CCDC188 MIR3618 MIR1286 LOC284865 DGCR6L TRMT2A MIR6816 MIR1306 C22orf29 ARVCF RANBP1 DGCR8 RTN4R TXNRD2 ZDHHC8 MIR4761 TBX1 TANGO2 LINC00896 MIR185 LOC440792 GNB1L
nsv834133	Chr.22:20029363 - 20176708 on Build GRCh38	Loss	CCDC188 RANBP1 DGCR8 MIR3618 ZDHHC8 TANGO2 TRMT2A MIR185 MIR6816 MIR1306

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

RNA metabolism protein, RNA processing factor, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

gene silencing by RNA
primary miRNA processing
regulation of stem cell proliferation
RNA phosphodiester bond hydrolysis, endonucleolytic

Function(s)

double-stranded RNA binding
ribonuclease III activity
protein binding
heme binding
protein homodimerization activity
metal ion binding
primary miRNA binding