Hs04358724_cn

• Gene Symbol: EXOSC4
• Assay Reference Genome Location: Chr.8:144070888 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 54512
• Gene Name: exosome component 4
• Gene Aliases: RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A
• Location: Chr.8:144064092-144080648 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EXOSC4	XM_011517134.2			XP_011515436.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	LOC101928953 LRRC14 MAF1 MIR6848 SLC39A4 SHARPIN SCRT1 BOP1 SCX MIR6846 EXOSC4 CYHR1 CYC1 DGAT1 WDR97 TMEM249 MFSD3 MIR1234 MIR7112 HSF1 FOXH1 MIR939 SPATC1 MIR6893 HGH1 VPS28 SLC52A2 KIFC2 FBXL6 TONSL OPLAH CPSF1 TONSL-AS1 GRINA PPP1R16A PLEC ADCK5 MROH1 MIR6847 GPT RECQL4 LOC101928902 MIR6849 SMPD5 PARP10 MIR661 GPAA1
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	OPLAH MAF1 GRINA SHARPIN PLEC MIR6846 MIR6847 EXOSC4 CYC1 WDR97 SMPD5 PARP10 GPAA1 SPATC1
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	OPLAH MAF1 GRINA SHARPIN EPPK1 PLEC MIR6846 MIR6847 EXOSC4 CYC1 WDR97 SMPD5 PARP10 MIR661 GPAA1 SPATC1
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	NRBP2 PUF60 OPLAH GRINA EPPK1 LOC642574 MIR937 PLEC MIR6846 MIR6845 MIR6847 EXOSC4 SMPD5 PARP10 MIR661 SCRIB SPATC1
nsv1025071	Chr.8:144044224 - 144300847 on Build GRCh38	Gain	HGH1 OPLAH MAF1 SHARPIN BOP1 SCX MIR6846 MROH1 MIR6847 EXOSC4 CYC1 WDR97 SMPD5 MIR7112 HSF1 GPAA1 SPATC1
esv29971	Chr.8:144068526 - 144172197 on Build GRCh38	Loss	HGH1 MROH1 MIR6847 MAF1 EXOSC4 CYC1 WDR97 SHARPIN GPAA1
nsv466014	Chr.8:144007080 - 144224185 on Build GRCh38	Loss	HGH1 OPLAH MAF1 SHARPIN MIR6846 MROH1 MIR6847 EXOSC4 CYC1 WDR97 SMPD5 GPAA1 SPATC1
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	LOC101928953 LRRC14 MAF1 MIR6848 SLC39A4 SHARPIN SCRT1 BOP1 SCX MIR6846 EXOSC4 CYHR1 CYC1 DGAT1 WDR97 TMEM249 MFSD3 MIR1234 MIR7112 HSF1 FOXH1 MIR939 SPATC1 MIR6893 HGH1 VPS28 SLC52A2 KIFC2 FBXL6 TONSL OPLAH CPSF1 TONSL-AS1 GRINA PPP1R16A PLEC ADCK5 MROH1 MIR6847 GPT RECQL4 LOC101928902 MIR6849 SMPD5 PARP10 MIR661 GPAA1
nsv6447	Chr.8:144064665 - 144087389 on Build GRCh38	Insertion	MIR6847 EXOSC4 GPAA1
dgv906n27	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	HGH1 OPLAH MAF1 GRINA SHARPIN EPPK1 PLEC MIR6846 MROH1 MIR6847 EXOSC4 CYC1 WDR97 SMPD5 PARP10 MIR661 GPAA1 SPATC1
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	OPLAH MAF1 GRINA SHARPIN PLEC MIR6846 MIR6847 EXOSC4 CYC1 WDR97 SMPD5 PARP10 MIR661 GPAA1 SPATC1
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	PLEC MIR6846 MIR6847 OPLAH EXOSC4 CYC1 GRINA SMPD5 PARP10 MIR661 GPAA1 SPATC1
nsv428208	Chr.8:144041826 - 144722291 on Build GRCh38	Gain	ZNF251 LOC101928953 LRRC14 MAF1 MIR6848 SLC39A4 SHARPIN SCRT1 BOP1 SCX MIR6846 ARHGAP39 EXOSC4 CYHR1 C8orf82 CYC1 DGAT1 WDR97 TMEM249 MFSD3 MIR1234 MIR7112 HSF1 FOXH1 MIR939 SPATC1 MIR6893 HGH1 VPS28 SLC52A2 KIFC2 FBXL6 TONSL OPLAH CPSF1 TONSL-AS1 PPP1R16A ADCK5 MROH1 MIR6847 GPT RECQL4 LRRC24 LOC101928902 MIR6849 SMPD5 GPAA1
nsv612907	Chr.8:143917935 - 144097007 on Build GRCh38	Gain+Loss	PLEC MIR6846 MIR6847 OPLAH EXOSC4 CYC1 GRINA SMPD5 PARP10 MIR661 GPAA1 SPATC1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

exoribonuclease

Gene Ontology Categories:

Process(es)

maturation of 5.8S rRNA
nuclear-transcribed mRNA catabolic process
rRNA processing
rRNA catabolic process
positive regulation of cell growth
rRNA 3'-end processing
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
U4 snRNA 3'-end processing
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
DNA deamination
defense response to virus
nuclear mRNA surveillance
histone mRNA catabolic process
polyadenylation-dependent snoRNA 3'-end processing
RNA phosphodiester bond hydrolysis, exonucleolytic

Function(s)

3'-5'-exoribonuclease activity
exoribonuclease activity
protein binding
AU-rich element binding