Hs04550737_cn

• Gene Symbol: NTRK1
• Assay Reference Genome Location: Chr.1:156838938 on build GRCh38
• Cytoband: 1q23.1

Target Gene Details

• Entrez Gene ID: 4914
• Gene Name: neurotrophic receptor tyrosine kinase 1
• Gene Aliases: MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA
• Location: Chr.1:156815750-156881850 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NTRK1	NM_001007792.1			NP_001007793.1
	AK126428.1
	CR936794.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv831648	Chr.1:156694085 - 156912126 on Build GRCh38	Loss	PRCC CRABP2 HDGF SH2D2A INSRR NTRK1 PEAR1 ISG20L2 MRPL24 RRNAD1
nsv831659	Chr.1:156771159 - 156980204 on Build GRCh38	Loss	PRCC LRRC71 ARHGEF11 SH2D2A INSRR MIR765 NTRK1 PEAR1
nsv998265	Chr.1:156834329 - 156903671 on Build GRCh38	Gain	INSRR NTRK1 PEAR1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

activation of MAPKK activity
positive regulation of protein phosphorylation
protein phosphorylation
microtubule-based movement
axon guidance
aging
learning or memory
circadian rhythm
negative regulation of cell proliferation
response to radiation
programmed cell death involved in cell development
positive regulation of neuron projection development
response to activity
peptidyl-tyrosine phosphorylation
olfactory nerve development
B cell differentiation
response to nutrient levels
nerve growth factor signaling pathway
mechanoreceptor differentiation
response to drug
positive regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
response to ethanol
positive regulation of Ras protein signal transduction
protein autophosphorylation
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
phosphatidylinositol-mediated signaling
sympathetic nervous system development
response to axon injury
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of NF-kappaB transcription factor activity
response to hydrostatic pressure
response to electrical stimulus
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
Sertoli cell development
axonogenesis involved in innervation
behavioral response to formalin induced pain
positive regulation of ERK1 and ERK2 cascade
cellular response to nicotine
cellular response to nerve growth factor stimulus

Function(s)

transmembrane receptor protein tyrosine kinase activity
GPI-linked ephrin receptor activity
neurotrophin p75 receptor binding
protein binding
ATP binding
nerve growth factor receptor activity
kinase binding
protein homodimerization activity
neurotrophin binding
nerve growth factor binding