Hs04564182_cn

• Gene Symbol: SOCS5
• Assay Reference Genome Location: Chr.2:46738629 on build GRCh38
• Cytoband: 2p21

Target Gene Details

• Entrez Gene ID: 9655
• Gene Name: suppressor of cytokine signaling 5
• Gene Aliases: CIS6, CISH6, Cish5, SOCS-5
• Location: Chr.2:46698960-46762788 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SOCS5	NM_014011.4			NP_054730.1
	NM_144949.2			NP_659198.1
	AB014571.1
	AF073958.1			AAD40484.1
	AK290194.1
	AK296796.1
	AL136896.1			CAB66830.1
	BC032862.1			AAH32862.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1013079	Chr.2:46722198 - 46771278 on Build GRCh38	Loss	SOCS5

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

kinase modulator

Gene Ontology Categories:

Process(es)

epidermal growth factor receptor signaling pathway
negative regulation of epidermal growth factor-activated receptor activity
JAK-STAT cascade
negative regulation of signal transduction
cell growth
protein ubiquitination
cytokine-mediated signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of interleukin-6 production
regulation of growth
positive regulation of T-helper 1 cell differentiation
negative regulation of T-helper 2 cell differentiation
negative regulation of JAK-STAT cascade
negative regulation of inflammatory response
negative regulation of monocyte chemotactic protein-1 production
negative regulation of endothelial cell activation

Function(s)

protein kinase inhibitor activity
epidermal growth factor receptor binding
protein binding
receptor tyrosine kinase binding