Hs04741517_cn

• Gene Symbol: PAK2
• Assay Reference Genome Location: Chr.3:196764265 on build GRCh38
• Cytoband: 3q29

Target Gene Details

• Entrez Gene ID: 5062
• Gene Name: p21 (RAC1) activated kinase 2
• Gene Aliases: PAK65, PAKgamma
• Location: Chr.3:196739857-196832647 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PAK2	NM_002577.4			NP_002568.2
	XM_017006501.1			XP_016861990.1
	AI140979.1
	AK291339.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3599293	Chr.3:196759100 - 197444213 on Build GRCh38	Gain	PIGZ NCBP2 MELTF MIR4797 NCBP2-AS2 DLG1-AS1 PAK2 MFI2-AS1 SENP5 DLG1
nsv1009975	Chr.3:196680410 - 196822871 on Build GRCh38	Gain	PIGX PAK2 CEP19
nsv829829	Chr.3:196747858 - 196887060 on Build GRCh38	Loss	PAK2 SENP5
nsv1001045	Chr.3:196703082 - 196900384 on Build GRCh38	Gain	PIGX PAK2 CEP19 SENP5
nsv1003135	Chr.3:196621850 - 197012082 on Build GRCh38	Gain	PIGZ NCBP2 NRROS MELTF NCBP2-AS2 PIGX PAK2 MFI2-AS1 CEP19 LINC01063 SENP5
esv2763775	Chr.3:196727069 - 197015419 on Build GRCh38	Gain+Loss	PIGZ NCBP2 MELTF NCBP2-AS2 PIGX PAK2 MFI2-AS1 SENP5
nsv1014692	Chr.3:196515378 - 196804953 on Build GRCh38	Gain	FBXO45 NRROS WDR53 PIGX PAK2 CEP19 LINC01063

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

mitotic cell cycle
stimulatory C-type lectin receptor signaling pathway
protein phosphorylation
negative regulation of protein kinase activity
apoptotic process
signal transduction
viral process
phosphorylation
peptidyl-serine phosphorylation
signal transduction by protein phosphorylation
T cell costimulation
Fc-epsilon receptor signaling pathway
regulation of growth
negative regulation of apoptotic process
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
regulation of defense response to virus by virus
positive regulation of peptidyl-tyrosine phosphorylation
T cell receptor signaling pathway
dendritic spine development
positive regulation of protein tyrosine kinase activity
cellular response to organic cyclic compound
cell-cell adhesion
positive regulation of extrinsic apoptotic signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Function(s)

protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase binding
protein tyrosine kinase activator activity
identical protein binding
cadherin binding involved in cell-cell adhesion