Hs05014841_cn

• Gene Symbol: EGFR
• Assay Reference Genome Location: Chr.7:55180129 on build GRCh38
• Cytoband: 7p11.2

Target Gene Details

• Entrez Gene ID: 1956
• Gene Name: epidermal growth factor receptor
• Gene Aliases: ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
• Location: Chr.7:55019032-55207338 on Build GRCh38
• Assay Gene Location: Within Intron 21

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EGFR	NM_005228.3			NP_005219.2
	AB209442.1			BAD92679.1
	AK225422.1
	AK290352.1
	AK294750.1
	AU137334.1
	AY550966.1			AAT52212.1
	BC094761.1			AAH94761.1
	DQ088980.1
	GU255993.1
	HQ912715.1
	K03193.1			AAA52371.1
	X00588.1			CAA25240.1
	X00663.1			CAA25282.1

Target Gene Details

• Entrez Gene ID: 100507500
• Gene Name: EGFR antisense RNA 1
• Gene Aliases: -
• Location: Chr.7:55179750-55188949 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
EGFR-AS1	NR_047551.1	2	2442
	AK123474.1	2	2427

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2734425	Chr.7:53868335 - 55917254 on Build GRCh38	Deletion	SEC61G LOC101060341 VSTM2A-OT1 ELDR LANCL2 VOPP1 HPVC1 LOC100996654 EGFR LINC01445 EGFR-AS1 VSTM2A LOC107986797 PSPHP1 FKBP9P1 SEPT14 ZNF713

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

MAPK cascade
activation of MAPKK activity
cell morphogenesis
ossification
embryonic placenta development
positive regulation of protein phosphorylation
hair follicle development
response to stress
signal transduction
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
activation of phospholipase C activity
salivary gland morphogenesis
learning or memory
cell proliferation
positive regulation of cell proliferation
regulation of phosphatidylinositol 3-kinase signaling
single organismal cell-cell adhesion
peptidyl-tyrosine phosphorylation
cerebral cortex cell migration
positive regulation of cell growth
positive regulation of cell migration
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
positive regulation of catenin import into nucleus
ERBB2 signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of protein catabolic process
positive regulation of phosphorylation
activation of phospholipase A2 activity by calcium-mediated signaling
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of nitric oxide biosynthetic process
positive regulation of DNA repair
positive regulation of DNA replication
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
digestive tract morphogenesis
positive regulation of epithelial cell proliferation
regulation of peptidyl-tyrosine phosphorylation
regulation of nitric-oxide synthase activity
protein insertion into membrane
positive regulation of protein kinase B signaling
morphogenesis of an epithelial fold
eyelid development in camera-type eye
response to UV-A
positive regulation of ERK1 and ERK2 cascade
cellular response to amino acid stimulus
cellular response to epidermal growth factor stimulus
cellular response to estradiol stimulus
positive regulation of production of miRNAs involved in gene silencing by miRNA
regulation of cell motility

Function(s)

chromatin binding
double-stranded DNA binding
MAP kinase kinase kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
transmembrane signaling receptor activity
epidermal growth factor-activated receptor activity
Ras guanyl-nucleotide exchange factor activity
protein binding
ATP binding
enzyme binding
protein phosphatase binding
nitric-oxide synthase regulator activity
ubiquitin protein ligase binding
identical protein binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
actin filament binding
cadherin binding involved in cell-cell adhesion