Hs05406075_cn

• Gene Symbol: TFAP4
• Assay Reference Genome Location: Chr.16:4259714 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 7023
• Gene Name: transcription factor AP-4 (activating enhancer binding protein 4)
• Gene Aliases: AP-4, bHLHc41
• Location: Chr.16:4257186-4273000 on Build GRCh38
• Assay Gene Location: Within Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TFAP4	NM_003223.2			NP_003214.1
	XM_011522633.2			XP_011520935.1
	XM_011522635.2			XP_011520937.1
	AB209146.1			BAD92383.1
	BC010576.1			AAH10576.1
	BU159415.1
	CR541726.1			CAG46527.1
	S73885.1			AAB32235.1
	X57435.1			CAA40683.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1046986	Chr.16:4049000 - 5555721 on Build GRCh38	Gain	NAGPA UBN1 VASN SMIM22 LOC105371063 SEC14L5 DNAJA3 CORO7-PAM16 C16orf89 ROGDI UBALD1 ADCY9 CDIP1 GLYR1 ZNF500 GLIS2-AS1 SEPT12 MIR6769A C16orf96 EEF2KMT CORO7 ANKS3 NMRAL1 RBFOX1 LINC01569 ALG1 NUDT16L1 GLIS2 SRL MGRN1 PPL PAM16 C16orf71 HMOX2 NAGPA-AS1 TFAP4
esv21490	Chr.16:3825338 - 4270692 on Build GRCh38	Gain+Loss	LINC01569 ADCY9 LOC105371063 CREBBP TFAP4 SRL LOC102724927
nsv527866	Chr.16:4206462 - 4412618 on Build GRCh38	Loss	CORO7-PAM16 LINC01569 PAM16 GLIS2-AS1 VASN LOC105371063 GLIS2 CORO7 TFAP4 SRL

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of cell cycle arrest
cellular response to dexamethasone stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding