Hs05440983_cn

• Gene Symbol: NLRC5
• Assay Reference Genome Location: Chr.16:57020053 on build GRCh38
• Cytoband: 16q13

Target Gene Details

• Entrez Gene ID: 84166
• Gene Name: NLR family CARD domain containing 5
• Gene Aliases: CLR16.1, NOD27, NOD4
• Location: Chr.16:56989547-57083524 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NLRC5	NM_032206.4			NP_115582.4
	XM_005256193.2			XP_005256250.1
	XM_005256194.3			XP_005256251.1
	XM_005256195.2			XP_005256252.1
	XM_005256196.2			XP_005256253.1
	XM_005256197.2			XP_005256254.1
	XM_005256199.3			XP_005256256.1
	XM_005256201.3			XP_005256258.1
	XM_006721297.2			XP_006721360.1
	XM_006721298.2			XP_006721361.1
	XM_006721300.2			XP_006721363.1
	XM_011523373.2			XP_011521675.1
	XM_011523375.2			XP_011521677.1
	XM_017023766.1			XP_016879255.1
	XM_017023767.1			XP_016879256.1
	XM_017023768.1			XP_016879257.1
	XM_017023769.1			XP_016879258.1
	XM_017023770.1			XP_016879259.1
	XM_017023771.1			XP_016879260.1
	AK074182.1			BAB85008.1
	AK097030.1
	AL704292.1
	DB293035.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1059098	Chr.16:56733938 - 57028336 on Build GRCh38	Gain	NLRC5 MIR138-2 HERPUD1 NUP93 MIR6863 SLC12A3 CETP
nsv827683	Chr.16:57016822 - 57147283 on Build GRCh38	Loss	NLRC5 CPNE2

More Information

Additional Information:

For this assay, SNP(s) [rs79162839] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

non-motor microtubule binding protein

Gene Ontology Categories:

Process(es)

negative regulation of NF-kappaB transcription factor activity
negative regulation of type I interferon production
regulation of kinase activity
innate immune response
positive regulation of MHC class I biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
positive regulation of interferon-gamma-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
positive regulation of type I interferon-mediated signaling pathway

Function(s)

RNA polymerase II core promoter sequence-specific DNA binding
protein binding
ATP binding