Hs05456953_cn

• Gene Symbol: TFAP4
• Assay Reference Genome Location: Chr.16:4265149 on build GRCh38
• Cytoband: 16p13.3

Target Gene Details

• Entrez Gene ID: 7023
• Gene Name: transcription factor AP-4 (activating enhancer binding protein 4)
• Gene Aliases: AP-4, bHLHc41
• Location: Chr.16:4257186-4273000 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TFAP4	NM_003223.2			NP_003214.1
	XM_011522633.2			XP_011520935.1
	XM_011522635.2			XP_011520937.1
	AB209146.1	1	2039	BAD92383.1
	AK309301.1
	BC010576.1			AAH10576.1
	BU159415.1
	CR541726.1			CAG46527.1
	DA449763.1
	S73885.1			AAB32235.1
	X57435.1			CAA40683.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1046986	Chr.16:4049000 - 5555721 on Build GRCh38	Gain	NMRAL1 SEPT12 SMIM22 DNAJA3 HMOX2 C16orf89 GLYR1 ZNF500 TFAP4 VASN MIR6769A GLIS2 PAM16 MGRN1 PPL SRL UBALD1 NAGPA-AS1 ALG1 SEC14L5 EEF2KMT ANKS3 LOC105371063 CORO7 UBN1 GLIS2-AS1 NUDT16L1 CDIP1 CORO7-PAM16 LINC01569 C16orf96 ROGDI RBFOX1 C16orf71 NAGPA ADCY9
esv21490	Chr.16:3825338 - 4270692 on Build GRCh38	Gain+Loss	LOC105371063 LINC01569 CREBBP LOC102724927 TFAP4 SRL ADCY9
nsv527866	Chr.16:4206462 - 4412618 on Build GRCh38	Loss	LOC105371063 LINC01569 GLIS2 CORO7 PAM16 GLIS2-AS1 TFAP4 VASN SRL CORO7-PAM16

More Information

Additional Information:

For this assay, SNP(s) [rs115769827] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA-binding transcription factor

Gene Ontology Categories:

Process(es)

transcription from RNA polymerase II promoter
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
negative regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
positive regulation by host of viral transcription
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of cell cycle arrest
cellular response to dexamethasone stimulus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
protein binding
protein homodimerization activity
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding