Hs05462884_cn

• Gene Symbol: DPEP1
• Assay Reference Genome Location: Chr.16:89635294 on build GRCh38
• Cytoband: 16q24.3

Target Gene Details

• Entrez Gene ID: 1800
• Gene Name: dipeptidase 1 (renal)
• Gene Aliases: MBD1, MDP, RDP
• Location: Chr.16:89613308-89641540 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DPEP1	NM_001128141.2			NP_001121613.1
	NM_004413.3			NP_004404.1
	XM_005256285.4			XP_005256342.1
	XM_005256286.3			XP_005256343.1
	XM_011522925.2			XP_011521227.1
	XM_017023009.1			XP_016878498.1
	AK309577.1
	BC017023.1			AAH17023.1
	BM152944.1
	BT006664.1			AAP35310.1
	CR457404.1			CAG33685.1
	D13138.1			BAA02431.1
	J05257.1			AAB59410.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2715183	Chr.16:89634416 - 89635789 on Build GRCh38	Deletion	DPEP1
esv2762221	Chr.16:89610380 - 90039318 on Build GRCh38	Gain+Loss	SPATA33 CENPBD1 CHMP1A FANCA DPEP1 TUBB3 CDK10 TCF25 GAS8-AS1 AFG3L1P LOC105371419 DEF8 MC1R SPATA2L DBNDD1 GAS8 SPIRE2 LOC107984817 VPS9D1-AS1 ZNF276 VPS9D1
nsv952078	Chr.16:89602793 - 89640192 on Build GRCh38	Deletion	DPEP1
nsv1930	Chr.16:89633876 - 89640750 on Build GRCh38	Insertion	DPEP1
nsv428331	Chr.16:89216635 - 90185980 on Build GRCh38	Gain+Loss	CHMP1A SPG7 SNORD68 FANCA DPEP1 LOC105371414 TUBB3 CDK10 TCF25 ANKRD11 AFG3L1P LOC105371419 DEF8 LOC100287036 ZNF276 SPATA33 CENPBD1 LOC101927817 RPL13 GAS8-AS1 MC1R SPATA2L DBNDD1 GAS8 FAM157C CPNE7 TUBB8P7 PRDM7 SPIRE2 LOC107984817 URAHP VPS9D1-AS1 ZNF778 VPS9D1
nsv573739	Chr.16:89625890 - 89696855 on Build GRCh38	Gain	SPATA33 CHMP1A SPATA2L DPEP1 CDK10
esv2715186	Chr.16:89635030 - 89635269 on Build GRCh38	Deletion	DPEP1
nsv1063483	Chr.16:89347250 - 89661187 on Build GRCh38	Gain	SPATA33 ANKRD11 CHMP1A SPG7 SNORD68 CPNE7 LOC101927817 DPEP1 RPL13
nsv482951	Chr.16:88633593 - 90228345 on Build GRCh38	Loss	SNAI3 CHMP1A APRT SLC22A31 LOC105371414 TRAPPC2L ANKRD11 AFG3L1P LOC105371419 DEF8 LOC100289580 CYBA LOC100129697 PIEZO1 ZNF276 LOC105371409 SPATA33 RNF166 ACSF3 LOC107987238 IL17C GALNS LOC101927817 MIR4722 CDT1 GAS8-AS1 MC1R DBNDD1 TUBB8P7 LOC107984817 VPS9D1-AS1 LINC00304 VPS9D1 SPG7 PABPN1L SNORD68 LOC400558 FANCA DPEP1 TUBB3 CDK10 TCF25 SNAI3-AS1 LOC100287036 CBFA2T3 CENPBD1 CDH15 RPL13 MVD CTU2 SPATA2L GAS8 FAM157C CPNE7 PRDM7 SPIRE2 LOC339059 URAHP ZNF778 LOC101927793
nsv509639	Chr.16:89513538 - 89775915 on Build GRCh38	Insertion	SPATA33 CHMP1A SPG7 SNORD68 FANCA DPEP1 RPL13 CDK10 SPATA2L CPNE7 VPS9D1-AS1 ZNF276 VPS9D1
nsv1066382	Chr.16:89537178 - 89661187 on Build GRCh38	Gain	SPATA33 CHMP1A SPG7 SNORD68 CPNE7 DPEP1 RPL13

More Information

Additional Information:

For this assay, SNP(s) [rs73265357] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

proteolysis
leukotriene metabolic process
glutathione metabolic process
xenobiotic metabolic process
apoptotic process
antibiotic metabolic process
negative regulation of cell migration
cellular response to drug
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
homocysteine metabolic process
cellular response to calcium ion
cellular response to nitric oxide
cellular lactam catabolic process

Function(s)

protein binding
metalloexopeptidase activity
dipeptidyl-peptidase activity
zinc ion binding
dipeptidase activity
GPI anchor binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
metallodipeptidase activity
modified amino acid binding