Hs05462884_cn

• Gene Symbol: DPEP1
• Assay Reference Genome Location: Chr.16:89635294 on build GRCh38
• Cytoband: 16q24.3

Target Gene Details

• Entrez Gene ID: 1800
• Gene Name: dipeptidase 1 (renal)
• Gene Aliases: MBD1, MDP, RDP
• Location: Chr.16:89613308-89641540 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DPEP1	NM_001128141.2			NP_001121613.1
	NM_004413.3			NP_004404.1
	XM_005256285.4			XP_005256342.1
	XM_005256286.3			XP_005256343.1
	XM_011522925.2			XP_011521227.1
	XM_017023009.1			XP_016878498.1
	AK309577.1
	BC017023.1			AAH17023.1
	BM152944.1
	BT006664.1			AAP35310.1
	CR457404.1			CAG33685.1
	D13138.1			BAA02431.1
	J05257.1			AAB59410.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2715183	Chr.16:89634416 - 89635789 on Build GRCh38	Deletion	DPEP1
nsv952078	Chr.16:89602793 - 89640192 on Build GRCh38	Deletion	DPEP1
nsv1057351	Chr.16:89610380 - 89707988 on Build GRCh38	Loss	VPS9D1 DPEP1 CDK10 SPATA33 CHMP1A SPATA2L
nsv428331	Chr.16:89216635 - 90185980 on Build GRCh38	Gain+Loss	TCF25 DBNDD1 SPIRE2 FANCA ZNF276 CDK10 CPNE7 LOC105371419 ZNF778 SPG7 DEF8 LOC100287036 LOC107984817 VPS9D1-AS1 FAM157C GAS8-AS1 SPATA33 LOC105371414 TUBB8P7 AFG3L1P SNORD68 TUBB3 MC1R DPEP1 PRDM7 SPATA2L RPL13 GAS8 VPS9D1 LOC101927817 URAHP CHMP1A CENPBD1 ANKRD11
nsv1930	Chr.16:89633876 - 89640750 on Build GRCh38	Insertion	DPEP1
nsv573739	Chr.16:89625890 - 89696855 on Build GRCh38	Gain	DPEP1 CDK10 SPATA33 CHMP1A SPATA2L
nsv1063483	Chr.16:89347250 - 89661187 on Build GRCh38	Gain	SPG7 SNORD68 LOC101927817 DPEP1 SPATA33 CHMP1A RPL13 CPNE7 ANKRD11
esv2715186	Chr.16:89635030 - 89635269 on Build GRCh38	Deletion	DPEP1
nsv482951	Chr.16:88633593 - 90228345 on Build GRCh38	Loss	TCF25 LOC101927793 APRT FANCA ZNF276 CDK10 RNF166 PIEZO1 IL17C LOC105371414 PABPN1L TUBB3 SNAI3 MC1R SNAI3-AS1 DPEP1 PRDM7 LOC100129697 CDH15 LOC400558 SPATA2L RPL13 GAS8 CYBA VPS9D1 LOC101927817 GALNS CENPBD1 DBNDD1 MVD SPIRE2 LOC105371409 LOC339059 CPNE7 LOC105371419 ZNF778 SPG7 DEF8 LINC00304 LOC100287036 LOC107984817 VPS9D1-AS1 CBFA2T3 FAM157C GAS8-AS1 SPATA33 TUBB8P7 AFG3L1P CDT1 LOC107987238 CTU2 SNORD68 TRAPPC2L MIR4722 SLC22A31 ACSF3 URAHP CHMP1A ANKRD11 LOC100289580
nsv509639	Chr.16:89513538 - 89775915 on Build GRCh38	Insertion	SNORD68 FANCA ZNF276 DPEP1 CDK10 SPATA2L RPL13 CPNE7 SPG7 VPS9D1-AS1 VPS9D1 SPATA33 CHMP1A
nsv1066382	Chr.16:89537178 - 89661187 on Build GRCh38	Gain	SPG7 SNORD68 DPEP1 SPATA33 CHMP1A RPL13 CPNE7

More Information

Additional Information:

For this assay, SNP(s) [rs73265357] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

protease

Gene Ontology Categories:

Process(es)

proteolysis
leukotriene metabolic process
glutathione metabolic process
xenobiotic metabolic process
apoptotic process
antibiotic metabolic process
negative regulation of cell migration
cellular response to drug
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
homocysteine metabolic process
cellular response to calcium ion
cellular response to nitric oxide
cellular lactam catabolic process

Function(s)

protein binding
metalloexopeptidase activity
dipeptidyl-peptidase activity
zinc ion binding
dipeptidase activity
GPI anchor binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
metallodipeptidase activity
modified amino acid binding