Hs05484145_cn

• Gene Symbol: SMURF2
• Assay Reference Genome Location: Chr.17:64542784 on build GRCh38
• Cytoband: 17q23.3

Target Gene Details

• Entrez Gene ID: 64750
• Gene Name: SMAD specific E3 ubiquitin protein ligase 2
• Gene Aliases: -
• Location: Chr.17:64542282-64662268 on Build GRCh38
• Assay Gene Location: Within Exon 20

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
SMURF2	XM_005257585.3	18	5299	XP_005257642.1
	XM_011525128.1	19	5317	XP_011523430.1
	CR936721.1	20	5434

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1066765	Chr.17:64520760 - 65128185 on Build GRCh38	Gain	PLEKHM1P1 MIR6080 LOC100507002 LOC146880 GNA13 MIR4315-2 AMZ2P1 CEP95 LRRC37A3 SMURF2

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
ubiquitin-dependent protein catabolic process
regulation of transforming growth factor beta receptor signaling pathway
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
ubiquitin-dependent SMAD protein catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of transcription, DNA-templated
Wnt signaling pathway, planar cell polarity pathway
positive regulation of canonical Wnt signaling pathway
positive regulation of trophoblast cell migration

Function(s)

ubiquitin-protein transferase activity
transforming growth factor beta receptor binding
protein binding
ligase activity
identical protein binding
SMAD binding
ubiquitin protein ligase activity