Hs05509729_cn

• Gene Symbol: ITGB3
• Assay Reference Genome Location: Chr.17:47305392 on build GRCh38
• Cytoband: 17q21.32

Target Gene Details

• Entrez Gene ID: 3690
• Gene Name: integrin subunit beta 3
• Gene Aliases: BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT
• Location: Chr.17:47253842-47312711 on Build GRCh38
• Assay Gene Location: Within Intron 13

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ITGB3	NM_000212.2			NP_000203.2
	BC127666.1
	BC127667.1
	J02703.1			AAA52589.1
	KC120777.1
	KC120778.1
	M20311.1			AAA60122.1
	M25108.1			AAA36121.1
	M35999.1			AAA35927.1
	U95204.1			AAB71380.1

Target Gene Details

• Entrez Gene ID: 102724508
• Gene Name: thyroid cancer-associated transcript 158
• Gene Aliases: -
• Location: Chr.17:47303443-47323901 on Build GRCh38
• Assay Gene Location: Within Intron 3

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
THCAT158	NR_110880.1
	NR_110881.1
	AA430297.1
	AA609236.1
	AW293117.1
	HY036509.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv3640696	Chr.17:47304736 - 47307029 on Build GRCh38	Loss	THCAT158 ITGB3

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

integrin

Gene Ontology Categories:

Process(es)

positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
platelet degranulation
cell-substrate junction assembly
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
blood coagulation
positive regulation of endothelial cell migration
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
smooth muscle cell migration
cell growth
cell migration
platelet activation
extracellular matrix organization
positive regulation of vascular endothelial growth factor receptor signaling pathway
cell-substrate adhesion
activation of protein kinase activity
negative regulation of lipid transport
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
tube development
apolipoprotein A-I-mediated signaling pathway
wound healing
regulation of bone resorption
negative regulation of low-density lipoprotein particle receptor biosynthetic process
viral entry into host cell
vascular endothelial growth factor receptor signaling pathway
mesodermal cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of lipoprotein metabolic process
leukocyte migration
negative chemotaxis
angiogenesis involved in wound healing
platelet aggregation

Function(s)

virus receptor activity
fibronectin binding
protease binding
protein disulfide isomerase activity
platelet-derived growth factor receptor binding
protein binding
coreceptor activity
fibroblast growth factor binding
enzyme binding
C-X3-C chemokine binding
insulin-like growth factor I binding
neuregulin binding
identical protein binding
vascular endothelial growth factor receptor 2 binding
cell adhesion molecule binding
extracellular matrix binding