Hs06112721_cn

• Gene Symbol: IL6ST
• Assay Reference Genome Location: Chr.5:55935989 on build GRCh38
• Cytoband: 5q11.2

Target Gene Details

• Entrez Gene ID: 3572
• Gene Name: interleukin 6 signal transducer
• Gene Aliases: CD130, CDW130, GP130, IL-6RB
• Location: Chr.5:55935095-55994993 on Build GRCh38
• Assay Gene Location: Within Exon 18

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
IL6ST	NM_001190981.1	16	7980	NP_001177910.1
	NM_002184.3	17	8163	NP_002175.2
	NM_175767.2	16	8080	NP_786943.1
	NR_120480.1	18	8209

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv830307	Chr.5:55867930 - 56048443 on Build GRCh38	Gain	IL6ST FLJ31104 IL31RA

More Information

Additional Information:

For this assay, SNP(s) [rs79149215] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

positive regulation of acute inflammatory response
positive regulation of adaptive immune response
glycogen metabolic process
positive regulation of cell proliferation
regulation of Notch signaling pathway
positive regulation of vascular endothelial growth factor production
positive regulation of cardiac muscle hypertrophy
viral process
cytokine-mediated signaling pathway
response to cytokine
interleukin-11-mediated signaling pathway
oncostatin-M-mediated signaling pathway
positive regulation of T cell proliferation
positive regulation of tyrosine phosphorylation of Stat1 protein
positive regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of apoptotic process
positive regulation of osteoblast differentiation
positive regulation of astrocyte differentiation
leukemia inhibitory factor signaling pathway
interleukin-6-mediated signaling pathway
interleukin-27-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway

Function(s)

ciliary neurotrophic factor receptor activity
interleukin-6 receptor activity
interleukin-11 receptor activity
leukemia inhibitory factor receptor activity
oncostatin-M receptor activity
ciliary neurotrophic factor receptor binding
interleukin-6 receptor binding
protein binding
growth factor binding
interleukin-11 binding
interleukin-6 binding
protein homodimerization activity
interleukin-27 receptor activity