Hs06197848_cn

• Gene Symbol: CNOT7
• Assay Reference Genome Location: Chr.8:17246668 on build GRCh38
• Cytoband: 8p22

Target Gene Details

• Entrez Gene ID: 29883
• Gene Name: CCR4-NOT transcription complex subunit 7
• Gene Aliases: CAF-1, CAF1, Caf1a, hCAF-1
• Location: Chr.8:17226030-17246909 on Build GRCh38
• Assay Gene Location: Overlaps Exon 1 - Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CNOT7	NM_001322087.1			NP_001309016.1
	NM_001322088.1			NP_001309017.1
	NM_001322090.1			NP_001309019.1
	NM_001322091.1			NP_001309020.1
	NM_001322092.1			NP_001309021.1
	NM_001322093.1			NP_001309022.1
	NM_001322094.1			NP_001309023.1
	NM_001322095.1			NP_001309024.1
	NM_001322096.1			NP_001309025.1
	NM_001322097.1			NP_001309026.1
	NM_001322098.1			NP_001309027.1
	NM_001322099.1			NP_001309028.1
	NM_001322100.1			NP_001309029.1
	NM_013354.6			NP_037486.2
	NM_054026.3			NP_473367.2
	AF086915.1			AAP97145.1
	AK001209.1
	AK021808.1
	AK023466.1
	AK225893.1
	AL528251.3
	AL833642.1
	BC007315.2			AAH07315.1
	BC060852.1			AAH60852.1
	BC070187.1			AAH70187.1
	BI458088.1
	BI552176.1
	DA508565.1
	DA720240.1
	DA752620.1
	L46722.1			AAF01500.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv831244	Chr.8:17105917 - 17270710 on Build GRCh38	Gain	VPS37A MICU3 LOC105379298 CNOT7 ZDHHC2

More Information

Additional Information:

For this assay, SNP(s) [rs117960717] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

mRNA polyadenylation factor

Gene Ontology Categories:

Process(es)

nuclear-transcribed mRNA poly(A) tail shortening
deadenylation-dependent decapping of nuclear-transcribed mRNA
carbohydrate metabolic process
transcription, DNA-templated
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction
positive regulation of cell proliferation
negative regulation of cell proliferation
negative regulation of gene expression
gene silencing by RNA
cytoplasmic mRNA processing body assembly
gene silencing by miRNA
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
positive regulation of transcription from RNA polymerase II promoter
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of mRNA catabolic process
RNA phosphodiester bond hydrolysis, exonucleolytic
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Function(s)

3'-5'-exoribonuclease activity
transcription factor activity, sequence-specific DNA binding
RNA binding
exoribonuclease activity
poly(A)-specific ribonuclease activity
signal transducer activity
protein binding
metal ion binding