Hs06458431_cn

• Gene Symbol: YES1
• Assay Reference Genome Location: Chr.18:770429 on build GRCh38
• Cytoband: 18p11.32

Target Gene Details

• Entrez Gene ID: 7525
• Gene Name: YES proto-oncogene 1, Src family tyrosine kinase
• Gene Aliases: HsT441, P61-YES, Yes, c-yes
• Location: Chr.18:721592-812326 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
YES1	NM_005433.3			NP_005424.1
	XM_005258139.3			XP_005258196.1
	XM_017025960.1			XP_016881449.1
	AK314063.1
	BC048960.1			AAH48960.1
	M15990.1			AAA35735.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv576236	Chr.18:319176 - 794272 on Build GRCh38	Gain	YES1 TYMS LOC105376854 CETN1 ENOSF1 COLEC12 CLUL1 TYMSOS
dgv5810n54	Chr.18:351004 - 2238246 on Build GRCh38	Gain	YES1 TYMS LOC105376854 CETN1 LOC388456 ADCYAP1 ENOSF1 COLEC12 LINC00470 CLUL1 TYMSOS
nsv576242	Chr.18:567127 - 841320 on Build GRCh38	Gain	YES1 TYMS CETN1 ENOSF1 CLUL1 TYMSOS
nsv528169	Chr.18:551688 - 2240220 on Build GRCh38	Loss	YES1 TYMS CETN1 LOC388456 ADCYAP1 ENOSF1 LINC00470 CLUL1 TYMSOS
nsv1060188	Chr.18:575087 - 863351 on Build GRCh38	Gain	YES1 TYMS CETN1 ENOSF1 CLUL1 TYMSOS
nsv1057808	Chr.18:766118 - 803577 on Build GRCh38	Loss	YES1
esv2761984	Chr.18:724222 - 855263 on Build GRCh38	Loss	YES1
nsv482935	Chr.18:10001 - 2900002 on Build GRCh38	Loss	YES1 LOC105376854 CETN1 CBX3P2 ADCYAP1 ENOSF1 THOC1 USP14 COLEC12 LINC00470 EMILIN2 METTL4 TYMSOS TYMS LOC388456 NDC80 LOC101926997 ROCK1P1 MIR8078 CLUL1 SMCHD1
nsv576228	Chr.18:69836 - 1506323 on Build GRCh38	Loss	YES1 LOC105376854 CETN1 ADCYAP1 ENOSF1 THOC1 USP14 COLEC12 LINC00470 TYMSOS TYMS LOC388456 ROCK1P1 MIR8078 CLUL1

More Information

Additional Information:

For this assay, SNP(s) [rs79946736] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cellular protein modification process
transmembrane receptor protein tyrosine kinase signaling pathway
glucose transport
cell differentiation
T cell costimulation
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of cell proliferation
regulation of vascular permeability
innate immune response
positive regulation of transcription from RNA polymerase II promoter
ephrin receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
leukocyte migration
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
epidermal growth factor receptor binding
protein binding
ATP binding
enzyme binding
ion channel binding