Hs06458431_cn

• Gene Symbol: YES1
• Assay Reference Genome Location: Chr.18:770429 on build GRCh38
• Cytoband: 18p11.32

Target Gene Details

• Entrez Gene ID: 7525
• Gene Name: YES proto-oncogene 1, Src family tyrosine kinase
• Gene Aliases: HsT441, P61-YES, Yes, c-yes
• Location: Chr.18:721592-812326 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
YES1	NM_005433.3			NP_005424.1
	XM_005258139.3			XP_005258196.1
	XM_017025960.1			XP_016881449.1
	AK314063.1
	BC048960.1			AAH48960.1
	M15990.1			AAA35735.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv576236	Chr.18:319176 - 794272 on Build GRCh38	Gain	CLUL1 TYMSOS YES1 COLEC12 TYMS ENOSF1 CETN1 LOC105376854
dgv5810n54	Chr.18:351004 - 2238246 on Build GRCh38	Gain	CLUL1 TYMSOS ADCYAP1 YES1 COLEC12 TYMS ENOSF1 CETN1 LINC00470 LOC105376854 LOC388456
nsv576242	Chr.18:567127 - 841320 on Build GRCh38	Gain	CLUL1 TYMSOS YES1 TYMS ENOSF1 CETN1
nsv528169	Chr.18:551688 - 2240220 on Build GRCh38	Loss	CLUL1 TYMSOS ADCYAP1 YES1 TYMS ENOSF1 CETN1 LINC00470 LOC388456
nsv1060188	Chr.18:575087 - 863351 on Build GRCh38	Gain	CLUL1 TYMSOS YES1 TYMS ENOSF1 CETN1
nsv1057808	Chr.18:766118 - 803577 on Build GRCh38	Loss	YES1
esv2761984	Chr.18:724222 - 855263 on Build GRCh38	Loss	YES1
nsv482935	Chr.18:10001 - 2900002 on Build GRCh38	Loss	CLUL1 THOC1 YES1 NDC80 TYMS ENOSF1 USP14 METTL4 MIR8078 SMCHD1 CBX3P2 LOC105376854 ROCK1P1 EMILIN2 TYMSOS ADCYAP1 COLEC12 CETN1 LOC101926997 LINC00470 LOC388456
nsv576228	Chr.18:69836 - 1506323 on Build GRCh38	Loss	CLUL1 THOC1 YES1 TYMS ENOSF1 USP14 MIR8078 LOC105376854 ROCK1P1 TYMSOS ADCYAP1 COLEC12 CETN1 LINC00470 LOC388456

More Information

Additional Information:

For this assay, SNP(s) [rs79946736] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cellular protein modification process
transmembrane receptor protein tyrosine kinase signaling pathway
glucose transport
cell differentiation
T cell costimulation
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of cell proliferation
regulation of vascular permeability
innate immune response
positive regulation of transcription from RNA polymerase II promoter
ephrin receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
leukocyte migration
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
epidermal growth factor receptor binding
protein binding
ATP binding
enzyme binding
ion channel binding