Hs06459307_cn

• Gene Symbol: THOC1
• Assay Reference Genome Location: Chr.18:248605 on build GRCh38
• Cytoband: 18p11.32

Target Gene Details

• Entrez Gene ID: 9984
• Gene Name: THO complex 1
• Gene Aliases: HPR1, P84, P84N5
• Location: Chr.18:214348-268059 on Build GRCh38
• Assay Gene Location: Within Intron 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
THOC1	NM_005131.2			NP_005122.2
	XM_011525772.2			XP_011524074.1
	XM_011525773.1			XP_011524075.1
	XM_017026103.1			XP_016881592.1
	XM_017026104.1			XP_016881593.1
	AK225067.1
	AK225709.1
	AK314755.1
	AY573303.1			AAT81409.1
	BC010381.1			AAH10381.1
	L36529.1			AAA53571.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv2174	Chr.18:240074 - 285087 on Build GRCh38	Deletion	THOC1
dgv3303n100	Chr.18:219990 - 290812 on Build GRCh38	Gain	THOC1
nsv576227	Chr.18:52933 - 322183 on Build GRCh38	Gain	COLEC12 ROCK1P1 USP14 MIR8078 THOC1
esv3641475	Chr.18:153985 - 282924 on Build GRCh38	Gain	USP14 THOC1
nsv518642	Chr.18:196829 - 331506 on Build GRCh38	Gain	COLEC12 USP14 THOC1
nsv1064150	Chr.18:99036 - 321710 on Build GRCh38	Gain	COLEC12 ROCK1P1 USP14 MIR8078 THOC1
dgv3301n100	Chr.18:11543 - 326679 on Build GRCh38	Gain	COLEC12 ROCK1P1 USP14 MIR8078 THOC1
nsv1160503	Chr.18:200576 - 249255 on Build GRCh38	Duplication	USP14 THOC1
nsv482935	Chr.18:10001 - 2900002 on Build GRCh38	Loss	LOC105376854 METTL4 CLUL1 ROCK1P1 CBX3P2 TYMSOS LINC00470 MIR8078 TYMS LOC101926997 COLEC12 NDC80 ENOSF1 EMILIN2 SMCHD1 YES1 LOC388456 ADCYAP1 USP14 CETN1 THOC1
dgv3302n100	Chr.18:136228 - 249310 on Build GRCh38	Gain	USP14 THOC1
esv3641473	Chr.18:128077 - 323706 on Build GRCh38	Gain	COLEC12 USP14 THOC1
nsv576228	Chr.18:69836 - 1506323 on Build GRCh38	Loss	LOC105376854 CLUL1 ROCK1P1 TYMSOS LINC00470 MIR8078 TYMS COLEC12 ENOSF1 YES1 LOC388456 ADCYAP1 USP14 CETN1 THOC1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

regulation of DNA recombination
termination of RNA polymerase II transcription
RNA processing
RNA export from nucleus
mRNA export from nucleus
apoptotic process
signal transduction
RNA splicing
mRNA 3'-end processing
replication fork processing
regulation of DNA-templated transcription, elongation
positive regulation of DNA-templated transcription, elongation
viral mRNA export from host cell nucleus
negative regulation of isotype switching to IgA isotypes
negative regulation of DNA damage checkpoint

Function(s)

DNA binding
RNA binding
protein binding