Hs06501214_cn

• Gene Symbol: YES1
• Assay Reference Genome Location: Chr.18:765971 on build GRCh38
• Cytoband: 18p11.32

Target Gene Details

• Entrez Gene ID: 7525
• Gene Name: YES proto-oncogene 1, Src family tyrosine kinase
• Gene Aliases: HsT441, P61-YES, Yes, c-yes
• Location: Chr.18:721592-812326 on Build GRCh38
• Assay Gene Location: Within Intron 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
YES1	NM_005433.3			NP_005424.1
	XM_005258139.3			XP_005258196.1
	XM_017025960.1			XP_016881449.1
	AK314063.1
	BC048960.1			AAH48960.1
	M15990.1			AAA35735.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv576236	Chr.18:319176 - 794272 on Build GRCh38	Gain	ENOSF1 YES1 TYMS LOC105376854 CLUL1 TYMSOS COLEC12 CETN1
dgv5810n54	Chr.18:351004 - 2238246 on Build GRCh38	Gain	ENOSF1 LOC388456 YES1 TYMS LOC105376854 LINC00470 CLUL1 TYMSOS COLEC12 ADCYAP1 CETN1
nsv576242	Chr.18:567127 - 841320 on Build GRCh38	Gain	ENOSF1 YES1 TYMS CLUL1 TYMSOS CETN1
nsv528169	Chr.18:551688 - 2240220 on Build GRCh38	Loss	ENOSF1 LOC388456 YES1 TYMS LINC00470 CLUL1 TYMSOS ADCYAP1 CETN1
nsv1060188	Chr.18:575087 - 863351 on Build GRCh38	Gain	ENOSF1 YES1 TYMS CLUL1 TYMSOS CETN1
esv2761984	Chr.18:724222 - 855263 on Build GRCh38	Loss	YES1
nsv482935	Chr.18:10001 - 2900002 on Build GRCh38	Loss	CBX3P2 ENOSF1 LOC101926997 ROCK1P1 LOC388456 EMILIN2 YES1 TYMS LINC00470 TYMSOS SMCHD1 NDC80 CETN1 USP14 LOC105376854 CLUL1 THOC1 COLEC12 ADCYAP1 MIR8078 METTL4
nsv576228	Chr.18:69836 - 1506323 on Build GRCh38	Loss	ENOSF1 ROCK1P1 LOC388456 YES1 TYMS LINC00470 TYMSOS CETN1 USP14 LOC105376854 CLUL1 THOC1 COLEC12 ADCYAP1 MIR8078

More Information

Additional Information:

For this assay, SNP(s) [rs115546519] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

cellular protein modification process
transmembrane receptor protein tyrosine kinase signaling pathway
glucose transport
cell differentiation
T cell costimulation
cellular response to platelet-derived growth factor stimulus
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of cell proliferation
regulation of vascular permeability
innate immune response
positive regulation of transcription from RNA polymerase II promoter
ephrin receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
leukocyte migration
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
epidermal growth factor receptor binding
protein binding
ATP binding
enzyme binding
ion channel binding