Hs06760455_cn

• Gene Symbol: BMP6
• Assay Reference Genome Location: Chr.6:7734858 on build GRCh38
• Cytoband: 6p24.3

Target Gene Details

• Entrez Gene ID: 654
• Gene Name: bone morphogenetic protein 6
• Gene Aliases: VGR, VGR1
• Location: Chr.6:7726778-7881728 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BMP6	NM_001718.4			NP_001709.1
	AK300628.1
	BC096084.2			AAH96084.1
	BC096085.2			AAH96085.1
	BC099624.1			AAH99624.1
	BC099625.1			AAH99625.1
	BC111763.1			AAI11764.1
	BC112352.1			AAI12353.1
	BC113018.1
	BC113019.1
	BC128031.1
	M60315.1			AAA36737.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv830582	Chr.6:7706847 - 7889468 on Build GRCh38	Loss	TXNDC5 BLOC1S5-TXNDC5 BMP6
nsv525566	Chr.6:7733826 - 7735555 on Build GRCh38	Loss	BMP6
esv3890787	Chr.6:6996928 - 7981438 on Build GRCh38	Loss	RREB1 SNRNP48 TXNDC5 RIOK1 BLOC1S5-TXNDC5 CAGE1 DSP LOC101928076 BMP6 SSR1

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

growth factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
eye development
kidney development
positive regulation of endothelial cell proliferation
endochondral ossification
type B pancreatic cell development
cellular iron ion homeostasis
inflammatory response
immune response
positive regulation of pathway-restricted SMAD protein phosphorylation
response to activity
positive regulation of bone mineralization
BMP signaling pathway
male genitalia development
positive regulation of lipopolysaccharide-mediated signaling pathway
response to magnesium ion
positive regulation of chondrocyte differentiation
positive regulation of aldosterone biosynthetic process
response to retinoic acid
growth
regulation of apoptotic process
regulation of MAPK cascade
positive regulation of endothelial cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
positive regulation of protein secretion
cartilage development
response to glucocorticoid
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
multicellular organismal iron ion homeostasis
cellular response to mechanical stimulus
cellular response to iron ion
cellular response to BMP stimulus
positive regulation of DNA-dependent DNA replication
positive regulation of aldosterone secretion

Function(s)

cytokine activity
transforming growth factor beta receptor binding
growth factor activity
protein heterodimerization activity
BMP receptor binding