Hs06803989_cn

• Gene Symbol: APOM
• Assay Reference Genome Location: Chr.6:31653435 on build GRCh38
• Cytoband: 6p21.33

Target Gene Details

• Entrez Gene ID: 55937
• Gene Name: apolipoprotein M
• Gene Aliases: G3a, HSPC336, NG20, apo-M
• Location: Chr.6:31652410-31658210 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APOM	NM_001256169.1			NP_001243098.1
	NR_045828.1
	AA846749.1
	AF161454.1			AAF29014.1
	BF344944.1
	CB054016.1
	CN428415.1

Target Gene Details

• Entrez Gene ID: 7917
• Gene Name: BCL2 associated athanogene 6
• Gene Aliases: BAG-6, BAT3, D6S52E, G3
• Location: Chr.6:31639028-31660900 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BAG6	XM_011514892.2	1	249	XP_011513194.1
	XM_017011275.1	1	249	XP_016866764.1
	XM_017011279.1			XP_016866768.1
	XM_017011283.1	1	249	XP_016866772.1
	XM_017011284.1	1	249	XP_016866773.1
	XM_017011287.1	1	249	XP_016866776.1
	XM_017011289.1	1	249	XP_016866778.1
	XM_017011290.1	1	249	XP_016866779.1
	XM_017011291.1	1	249	XP_016866780.1
	XM_017011292.1	1	249	XP_016866781.1
	XM_017011294.1	1	249	XP_016866783.1
	XM_017011295.1	1	249	XP_016866784.1
	XM_017011296.1	1	249	XP_016866785.1
	XM_017011298.1	1	249	XP_016866787.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1126749	Chr.6:31457323 - 32594423 on Build GRCh38	Deletion	C6orf47 ATP6V1G2 EGFL8 SLC44A4 TNF SAPCD1-AS1 SNORD84 DXO BTNL2 HCP5 SNORA38 NOTCH4 ATF6B CSNK2B PRRC2A LY6G6E MICB C2-AS1 C6orf25 VARS SNORD117 LSM2 LY6G5B SNORD52 LTA PBX2 NEU1 HLA-DRB6 DDX39B-AS1 C2 HCG23 MSH5-SAPCD1 NFKBIL1 APOM DDAH2 MSH5 MIR6833 HSPA1L AIF1 RNF5 LOC102725068 SAPCD1 NCR3 LST1 TNXA STK19 SKIV2L PRRT1 MIR6721 CFB ATP6V1G2-DDX39B BAG6 PPT2 PPT2-EGFL8 LY6G6F AGPAT1 LTB SNORD48 HSPA1B GPSM3 AGER DDX39B MCCD1 ABHD16A HCG26 LY6G5C VWA7 HLA-DRB5 ZBTB12 HSPA1A NELFE CLIC1 C4B MIR4646 LOC100287329 EHMT2 CYP21A2 LY6G6C LOC100507547 MIR1236 GPANK1 C6orf10 LY6G6D C6orf48 MIR6832 FKBPL HLA-DRA LOC101929163 C4A TNXB HLA-DRB1 CYP21A1P
nsv462871	Chr.6:31607499 - 31664357 on Build GRCh38	Loss	PRRC2A C6orf47 AIF1 MIR6832 BAG6 GPANK1 SNORA38 APOM
nsv1073969	Chr.6:31456422 - 33480523 on Build GRCh38	Deletion	ATP6V1G2 TNF SAPCD1-AS1 DXO BTNL2 PFDN6 NOTCH4 ATF6B MICB VARS SNORD117 LSM2 HLA-DQB1-AS1 LY6G5B TAP1 ZBTB22 WDR46 HSD17B8 C2 MSH5-SAPCD1 SYNGAP1 B3GALT4 NFKBIL1 HLA-DQB2 APOM DDAH2 MSH5 HLA-DOA HCG25 HSPA1L AIF1 PSMB8-AS1 RNF5 LOC102725068 SAPCD1 NCR3 TNXA SKIV2L MIR6721 RXRB CFB AGPAT1 SNORD48 MCCD1 ABHD16A ZBTB9 ZBTB12 C4B LOC100287329 EHMT2 TAP2 CYP21A2 GPANK1 BRD2 LY6G6D COL11A2 MIR6832 HLA-DRA RGL2 C4A TNXB HLA-DRB1 MIR6873 CYP21A1P HCG24 C6orf47 EGFL8 SLC44A4 SNORD84 HCP5 SNORA38 CSNK2B PRRC2A LY6G6E C2-AS1 C6orf25 RPS18 CUTA SNORD52 LTA PPP1R2P1 HLA-DPB2 PBX2 HLA-DOB NEU1 HLA-DRB6 DDX39B-AS1 HCG23 PSMB9 MIR6833 LST1 HLA-DMA STK19 HLA-DQA2 PRRT1 MIR3135B HLA-DMB TAPBP ATP6V1G2-DDX39B BAG6 KIFC1 PPT2 DAXX PPT2-EGFL8 HLA-DQB1 LY6G6F SLC39A7 LTB HSPA1B GPSM3 AGER DDX39B MIR6834 HCG26 LY6G5C VWA7 HLA-DRB5 HSPA1A MIR5004 NELFE CLIC1 MIR4646 HLA-DQA1 LY6G6C PHF1 LOC100507547 MIR1236 LOC100294145 HLA-DPA1 C6orf10 RING1 VPS52 C6orf48 FKBPL HLA-DPB1 LOC101929163 PSMB8 MIR219A1
dgv10403n54	Chr.6:31312324 - 32049763 on Build GRCh38	Loss	C6orf47 ATP6V1G2 SLC44A4 TNF SAPCD1-AS1 SNORD84 DXO HCP5 SNORA38 CSNK2B PRRC2A LY6G6E MICB C2-AS1 C6orf25 VARS SNORD117 LSM2 LY6G5B SNORD52 LTA NEU1 DDX39B-AS1 C2 MSH5-SAPCD1 NFKBIL1 APOM DDAH2 MSH5 HSPA1L AIF1 HLA-B LOC102725068 SAPCD1 NCR3 LST1 TNXA STK19 SKIV2L MIR6891 CFB ATP6V1G2-DDX39B BAG6 LY6G6F LTB SNORD48 HSPA1B DDX39B MCCD1 ABHD16A HCG26 LY6G5C VWA7 ZBTB12 MICA HSPA1A NELFE CLIC1 C4B MIR4646 LOC100287329 EHMT2 CYP21A2 LY6G6C MIR1236 GPANK1 LY6G6D C6orf48 MIR6832 C4A TNXB CYP21A1P
nsv1112900	Chr.6:31455323 - 33480423 on Build GRCh38	Deletion	ATP6V1G2 TNF SAPCD1-AS1 DXO BTNL2 PFDN6 NOTCH4 ATF6B MICB VARS SNORD117 LSM2 HLA-DQB1-AS1 LY6G5B TAP1 ZBTB22 WDR46 HSD17B8 C2 MSH5-SAPCD1 SYNGAP1 B3GALT4 NFKBIL1 HLA-DQB2 APOM DDAH2 MSH5 HLA-DOA HCG25 HSPA1L AIF1 PSMB8-AS1 RNF5 LOC102725068 SAPCD1 NCR3 TNXA SKIV2L MIR6721 RXRB CFB AGPAT1 SNORD48 MCCD1 ABHD16A ZBTB9 ZBTB12 C4B LOC100287329 EHMT2 TAP2 CYP21A2 GPANK1 BRD2 LY6G6D COL11A2 MIR6832 HLA-DRA RGL2 C4A TNXB HLA-DRB1 MIR6873 CYP21A1P HCG24 C6orf47 EGFL8 SLC44A4 SNORD84 HCP5 SNORA38 CSNK2B PRRC2A LY6G6E C2-AS1 C6orf25 RPS18 CUTA SNORD52 LTA PPP1R2P1 HLA-DPB2 PBX2 HLA-DOB NEU1 HLA-DRB6 DDX39B-AS1 HCG23 PSMB9 MIR6833 LST1 HLA-DMA STK19 HLA-DQA2 PRRT1 MIR3135B HLA-DMB TAPBP ATP6V1G2-DDX39B BAG6 KIFC1 PPT2 DAXX PPT2-EGFL8 HLA-DQB1 LY6G6F SLC39A7 LTB HSPA1B GPSM3 AGER DDX39B MIR6834 HCG26 LY6G5C VWA7 HLA-DRB5 HSPA1A MIR5004 NELFE CLIC1 MIR4646 HLA-DQA1 LY6G6C PHF1 LOC100507547 MIR1236 LOC100294145 HLA-DPA1 C6orf10 RING1 VPS52 C6orf48 FKBPL HLA-DPB1 LOC101929163 PSMB8 MIR219A1
dgv10404n54	Chr.6:31312550 - 32516591 on Build GRCh38	Loss	C6orf47 ATP6V1G2 EGFL8 SLC44A4 TNF SAPCD1-AS1 SNORD84 DXO BTNL2 HCP5 SNORA38 NOTCH4 ATF6B CSNK2B PRRC2A LY6G6E MICB C2-AS1 C6orf25 VARS SNORD117 LSM2 LY6G5B SNORD52 LTA PBX2 NEU1 DDX39B-AS1 C2 HCG23 MSH5-SAPCD1 NFKBIL1 APOM DDAH2 MSH5 MIR6833 HSPA1L AIF1 HLA-B RNF5 LOC102725068 SAPCD1 NCR3 LST1 TNXA STK19 SKIV2L PRRT1 MIR6891 MIR6721 CFB ATP6V1G2-DDX39B BAG6 PPT2 PPT2-EGFL8 LY6G6F AGPAT1 LTB SNORD48 HSPA1B GPSM3 AGER DDX39B MCCD1 ABHD16A HCG26 LY6G5C VWA7 ZBTB12 MICA HSPA1A NELFE CLIC1 C4B MIR4646 LOC100287329 EHMT2 CYP21A2 LY6G6C LOC100507547 MIR1236 GPANK1 C6orf10 LY6G6D C6orf48 MIR6832 FKBPL HLA-DRA LOC101929163 C4A TNXB CYP21A1P
nsv1161370	Chr.6:31600692 - 31714252 on Build GRCh38	Deletion	MIR4646 C6orf47 BAG6 GPANK1 LY6G6F SNORA38 APOM CSNK2B PRRC2A LY6G6E AIF1 MIR6832 ABHD16A LY6G5B LY6G5C
nsv830627	Chr.6:31528437 - 31692173 on Build GRCh38	Loss	C6orf47 ATP6V1G2 TNF ATP6V1G2-DDX39B BAG6 SNORD84 LTB SNORA38 CSNK2B PRRC2A DDX39B MCCD1 ABHD16A SNORD117 LY6G5B LTA LY6G5C LOC100287329 DDX39B-AS1 GPANK1 NFKBIL1 APOM AIF1 MIR6832 NCR3 LST1

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

apolipoprotein, transfer/carrier protein, chaperone

Gene Ontology Categories:

Process(es)

retinoid metabolic process
response to glucose
cholesterol efflux
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
negative regulation of plasma lipoprotein particle oxidation
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
cellular oxidant detoxification
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway

Function(s)

lipid transporter activity
phospholipid binding
antioxidant activity
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
ribosome binding
misfolded protein binding
proteasome binding
ubiquitin-specific protease binding