Hs06803989_cn

• Gene Symbol: APOM
• Assay Reference Genome Location: Chr.6:31653435 on build GRCh38
• Cytoband: 6p21.33

Target Gene Details

• Entrez Gene ID: 55937
• Gene Name: apolipoprotein M
• Gene Aliases: G3a, HSPC336, NG20, apo-M
• Location: Chr.6:31652410-31658210 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
APOM	NM_001256169.1			NP_001243098.1
	NR_045828.1
	AA846749.1
	AF161454.1			AAF29014.1
	BF344944.1
	CB054016.1
	CN428415.1

Target Gene Details

• Entrez Gene ID: 7917
• Gene Name: BCL2 associated athanogene 6
• Gene Aliases: BAG-6, BAT3, D6S52E, G3
• Location: Chr.6:31639028-31660900 on Build GRCh38
• Assay Gene Location: Within Exon 2

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
BAG6	XM_011514892.2	1	249	XP_011513194.1
	XM_017011275.1	1	249	XP_016866764.1
	XM_017011279.1			XP_016866768.1
	XM_017011283.1	1	249	XP_016866772.1
	XM_017011284.1	1	249	XP_016866773.1
	XM_017011287.1	1	249	XP_016866776.1
	XM_017011289.1	1	249	XP_016866778.1
	XM_017011290.1	1	249	XP_016866779.1
	XM_017011291.1	1	249	XP_016866780.1
	XM_017011292.1	1	249	XP_016866781.1
	XM_017011294.1	1	249	XP_016866783.1
	XM_017011295.1	1	249	XP_016866784.1
	XM_017011296.1	1	249	XP_016866785.1
	XM_017011298.1	1	249	XP_016866787.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv601942	Chr.6:31607499 - 31664357 on Build GRCh38	Loss	PRRC2A AIF1 APOM C6orf47 BAG6 SNORA38 GPANK1 MIR6832
nsv1126749	Chr.6:31457323 - 32594423 on Build GRCh38	Deletion	C4B RNF5 SLC44A4 NOTCH4 CLIC1 SKIV2L AGPAT1 SAPCD1-AS1 LSM2 SNORD117 LOC100287329 PBX2 STK19 FKBPL LOC101929163 LY6G6D NEU1 TNXA C6orf10 HCP5 LY6G5C LTB ATF6B GPANK1 LOC100507547 PRRT1 C2-AS1 TNF MCCD1 HLA-DRB1 LTA NELFE ATP6V1G2 LY6G6C LY6G6F HLA-DRB5 MIR1236 SNORD48 LY6G6E EGFL8 C6orf25 HSPA1A ABHD16A LOC102725068 HLA-DRA CFB PRRC2A PPT2 MIR6833 CSNK2B MIR6721 APOM C6orf47 VWA7 MIR4646 HCG26 CYP21A1P MICB LST1 HLA-DRB6 ZBTB12 AIF1 HSPA1B AGER CYP21A2 HCG23 MSH5 BAG6 DDX39B GPSM3 EHMT2 C2 NFKBIL1 SNORA38 C6orf48 MIR6832 NCR3 LY6G5B SNORD52 DDAH2 DXO C4A VARS TNXB DDX39B-AS1 SNORD84 ATP6V1G2-DDX39B MSH5-SAPCD1 PPT2-EGFL8 SAPCD1 HSPA1L BTNL2
dgv10403n54	Chr.6:31312324 - 32049763 on Build GRCh38	Loss	C4B SLC44A4 CLIC1 SKIV2L SAPCD1-AS1 LSM2 SNORD117 LOC100287329 STK19 LY6G6D NEU1 TNXA HCP5 LY6G5C LTB GPANK1 C2-AS1 TNF MCCD1 LTA NELFE ATP6V1G2 LY6G6C LY6G6F MIR6891 MIR1236 SNORD48 LY6G6E C6orf25 HSPA1A ABHD16A MICA LOC102725068 CFB PRRC2A CSNK2B APOM C6orf47 VWA7 MIR4646 HCG26 CYP21A1P MICB LST1 ZBTB12 AIF1 HSPA1B CYP21A2 MSH5 BAG6 DDX39B EHMT2 C2 NFKBIL1 SNORA38 C6orf48 MIR6832 HLA-B NCR3 LY6G5B SNORD52 DDAH2 DXO C4A VARS TNXB DDX39B-AS1 SNORD84 ATP6V1G2-DDX39B MSH5-SAPCD1 SAPCD1 HSPA1L
nsv1073969	Chr.6:31456422 - 33480523 on Build GRCh38	Deletion	LOC100294145 HLA-DQB1-AS1 HLA-DPB1 SLC44A4 HLA-DOB AGPAT1 SNORD117 STK19 LOC101929163 TNXA HCP5 HCG25 HLA-DPB2 LY6G5C LOC100507547 HLA-DMA NELFE ATP6V1G2 LY6G6C MIR3135B LY6G6F RPS18 MIR1236 SNORD48 HLA-DQB2 EGFL8 C6orf25 LOC102725068 HSD17B8 HLA-DRA DAXX PPT2 MIR6833 CSNK2B HCG24 TAP2 COL11A2 PSMB8 MICB KIFC1 ZBTB12 AIF1 CUTA CYP21A2 DDX39B GPSM3 PSMB8-AS1 EHMT2 NFKBIL1 C6orf48 MIR6832 NCR3 LY6G5B SNORD52 DXO C4A VARS PPP1R2P1 TAP1 PHF1 RXRB VPS52 DDX39B-AS1 MIR6873 SNORD84 ATP6V1G2-DDX39B PPT2-EGFL8 SAPCD1 SLC39A7 RGL2 BTNL2 C4B RNF5 HLA-DQA2 NOTCH4 CLIC1 MIR6834 SKIV2L SAPCD1-AS1 LSM2 ZBTB9 LOC100287329 WDR46 PBX2 FKBPL LY6G6D NEU1 C6orf10 MIR219A1 LTB PSMB9 BRD2 TAPBP ATF6B GPANK1 ZBTB22 PRRT1 C2-AS1 TNF MCCD1 HLA-DRB1 LTA PFDN6 HLA-DRB5 HLA-DOA LY6G6E HSPA1A ABHD16A CFB PRRC2A SYNGAP1 MIR6721 APOM C6orf47 VWA7 MIR5004 MIR4646 HCG26 HLA-DMB CYP21A1P LST1 HLA-DRB6 HLA-DPA1 HSPA1B AGER HCG23 MSH5 BAG6 C2 SNORA38 HLA-DQA1 DDAH2 TNXB RING1 B3GALT4 MSH5-SAPCD1 HLA-DQB1 HSPA1L
nsv1112900	Chr.6:31455323 - 33480423 on Build GRCh38	Deletion	LOC100294145 HLA-DQB1-AS1 HLA-DPB1 SLC44A4 HLA-DOB AGPAT1 SNORD117 STK19 LOC101929163 TNXA HCP5 HCG25 HLA-DPB2 LY6G5C LOC100507547 HLA-DMA NELFE ATP6V1G2 LY6G6C MIR3135B LY6G6F RPS18 MIR1236 SNORD48 HLA-DQB2 EGFL8 C6orf25 LOC102725068 HSD17B8 HLA-DRA DAXX PPT2 MIR6833 CSNK2B HCG24 TAP2 COL11A2 PSMB8 MICB KIFC1 ZBTB12 AIF1 CUTA CYP21A2 DDX39B GPSM3 PSMB8-AS1 EHMT2 NFKBIL1 C6orf48 MIR6832 NCR3 LY6G5B SNORD52 DXO C4A VARS PPP1R2P1 TAP1 PHF1 RXRB VPS52 DDX39B-AS1 MIR6873 SNORD84 ATP6V1G2-DDX39B PPT2-EGFL8 SAPCD1 SLC39A7 RGL2 BTNL2 C4B RNF5 HLA-DQA2 NOTCH4 CLIC1 MIR6834 SKIV2L SAPCD1-AS1 LSM2 ZBTB9 LOC100287329 WDR46 PBX2 FKBPL LY6G6D NEU1 C6orf10 MIR219A1 LTB PSMB9 BRD2 TAPBP ATF6B GPANK1 ZBTB22 PRRT1 C2-AS1 TNF MCCD1 HLA-DRB1 LTA PFDN6 HLA-DRB5 HLA-DOA LY6G6E HSPA1A ABHD16A CFB PRRC2A SYNGAP1 MIR6721 APOM C6orf47 VWA7 MIR5004 MIR4646 HCG26 HLA-DMB CYP21A1P LST1 HLA-DRB6 HLA-DPA1 HSPA1B AGER HCG23 MSH5 BAG6 C2 SNORA38 HLA-DQA1 DDAH2 TNXB RING1 B3GALT4 MSH5-SAPCD1 HLA-DQB1 HSPA1L
dgv10404n54	Chr.6:31312550 - 32516591 on Build GRCh38	Loss	C4B RNF5 SLC44A4 NOTCH4 CLIC1 SKIV2L AGPAT1 SAPCD1-AS1 LSM2 SNORD117 LOC100287329 PBX2 STK19 FKBPL LOC101929163 LY6G6D NEU1 TNXA C6orf10 HCP5 LY6G5C LTB ATF6B GPANK1 LOC100507547 PRRT1 C2-AS1 TNF MCCD1 LTA NELFE ATP6V1G2 LY6G6C LY6G6F MIR6891 MIR1236 SNORD48 LY6G6E EGFL8 C6orf25 HSPA1A ABHD16A MICA LOC102725068 HLA-DRA CFB PRRC2A PPT2 MIR6833 CSNK2B MIR6721 APOM C6orf47 VWA7 MIR4646 HCG26 CYP21A1P MICB LST1 ZBTB12 AIF1 HSPA1B AGER CYP21A2 HCG23 MSH5 BAG6 DDX39B GPSM3 EHMT2 C2 NFKBIL1 SNORA38 C6orf48 MIR6832 HLA-B NCR3 LY6G5B SNORD52 DDAH2 DXO C4A VARS TNXB DDX39B-AS1 SNORD84 ATP6V1G2-DDX39B MSH5-SAPCD1 PPT2-EGFL8 SAPCD1 HSPA1L BTNL2
nsv1161370	Chr.6:31600692 - 31714252 on Build GRCh38	Deletion	PRRC2A CSNK2B LY6G5B APOM C6orf47 MIR4646 LY6G6F AIF1 LY6G6E LY6G5C BAG6 ABHD16A SNORA38 GPANK1 MIR6832
nsv830627	Chr.6:31528437 - 31692173 on Build GRCh38	Loss	PRRC2A CSNK2B APOM C6orf47 SNORD117 LST1 LOC100287329 AIF1 LY6G5C LTB BAG6 DDX39B NFKBIL1 SNORA38 GPANK1 MIR6832 TNF NCR3 LY6G5B MCCD1 LTA ATP6V1G2 DDX39B-AS1 SNORD84 ATP6V1G2-DDX39B ABHD16A

More Information

• Set Membership: Intragenic, Exonic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

apolipoprotein, transfer/carrier protein, chaperone

Gene Ontology Categories:

Process(es)

retinoid metabolic process
response to glucose
cholesterol efflux
high-density lipoprotein particle remodeling
high-density lipoprotein particle assembly
high-density lipoprotein particle clearance
negative regulation of plasma lipoprotein particle oxidation
lipoprotein metabolic process
cholesterol homeostasis
reverse cholesterol transport
cellular oxidant detoxification
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway

Function(s)

lipid transporter activity
phospholipid binding
antioxidant activity
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
ribosome binding
misfolded protein binding
proteasome binding
ubiquitin-specific protease binding