Hs07131353_cn

• Gene Symbol: TYK2
• Assay Reference Genome Location: Chr.19:10362657 on build GRCh38
• Cytoband: 19p13.2

Target Gene Details

• Entrez Gene ID: 7297
• Gene Name: tyrosine kinase 2
• Gene Aliases: IMD35, JTK1
• Location: Chr.19:10350528-10380572 on Build GRCh38
• Assay Gene Location: Overlaps Intron 12 - Exon 13

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TYK2	NM_003331.4			NP_003322.3
	XM_011528245.1			XP_011526547.1
	XM_011528246.2			XP_011526548.1
	XM_011528247.1			XP_011526549.1
	XM_011528249.2			XP_011526551.1
	XM_011528251.1			XP_011526553.1
	XM_011528252.1			XP_011526554.1
	AK222672.1			BAD96392.1
	AK303627.1
	AK308360.1
	AK308379.1
	BC014243.2			AAH14243.1
	X54637.1			CAA38449.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv2415	Chr.19:10340631 - 10373197 on Build GRCh38	Insertion	TYK2
nsv518008	Chr.19:10338682 - 10426592 on Build GRCh38	Gain	TYK2 PDE4A MIR1181 CDC37 ICAM3
nsv470125	Chr.19:10334150 - 10380799 on Build GRCh38	Loss	TYK2 ICAM3

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
cell migration
cell differentiation
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
growth hormone receptor binding
protein binding
ATP binding
type 1 angiotensin receptor binding