Hs07533802_cn

• Gene Symbol: HHEX
• Assay Reference Genome Location: Chr.10:92690287 on build GRCh38
• Cytoband: 10q23.33

Target Gene Details

• Entrez Gene ID: 3087
• Gene Name: hematopoietically expressed homeobox
• Gene Aliases: HEX, HMPH, HOX11L-PEN, PRH, PRHX
• Location: Chr.10:92689924-92695651 on Build GRCh38
• Assay Gene Location: Within Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HHEX	NM_002729.4	1	364	NP_002720.1
	AK309463.1	1	333
	AK314891.1	1	333
	BC014336.1	1	337	AAH14336.1
	BC015110.1	1	337	AAH15110.1
	BC050638.1	1	304	AAH50638.1
	DB504532.1	1	364
	L16499.1	1	336	AAA02988.1
	X67235.1	1	308	CAA47661.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv1350n54	Chr.10:92689403 - 92690681 on Build GRCh38	Gain	HHEX
dgv168n67	Chr.10:92637392 - 92712752 on Build GRCh38	Gain	HHEX KIF11
nsv551939	Chr.10:92689930 - 92690681 on Build GRCh38	Gain+Loss	HHEX
nsv551938	Chr.10:92689860 - 92690681 on Build GRCh38	Loss	HHEX
nsv551929	Chr.10:92689529 - 92690255 on Build GRCh38	Gain+Loss	HHEX
dgv1351n54	Chr.10:92689478 - 92690472 on Build GRCh38	Gain	HHEX
dgv1352n54	Chr.10:92689583 - 92690681 on Build GRCh38	Gain+Loss	HHEX
nsv1046258	Chr.10:92107212 - 92706349 on Build GRCh38	Gain	CPEB3 MARCH5 HHEX KIF11 MARK2P9 IDE
esv29580	Chr.10:92689451 - 92690728 on Build GRCh38	Loss	HHEX

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

homeodomain transcription factor

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
in utero embryonic development
myeloid leukocyte differentiation
transcription, DNA-templated
mRNA export from nucleus
Notch signaling pathway
endoderm development
cell proliferation
anterior/posterior pattern specification
negative regulation of transcription by transcription factor localization
negative regulation of transcription by competitive promoter binding
Wnt signaling pathway
negative regulation of angiogenesis
poly(A)+ mRNA export from nucleus
interkinetic nuclear migration
cell differentiation
positive regulation of Wnt signaling pathway
B cell differentiation
thyroid gland development
negative regulation of vascular endothelial growth factor receptor signaling pathway
pancreas development
protein localization to nucleus
embryonic heart tube development
multicellular organism growth
regulation of cell proliferation
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
forebrain morphogenesis
primary lung bud formation
gall bladder development
hepatic duct development
hepatoblast differentiation
hepatocyte differentiation
DNA conformation change
primitive streak formation

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein binding
transcription factor binding
eukaryotic initiation factor 4E binding
DNA binding, bending
TBP-class protein binding
protein homodimerization activity
sequence-specific DNA binding
transcription regulatory region DNA binding
repressing transcription factor binding
HMG box domain binding