Hs07539728_cn

• Gene Symbol: HDAC4
• Assay Reference Genome Location: Chr.2:239401397 on build GRCh38
• Cytoband: 2q37.3

Target Gene Details

• Entrez Gene ID: 9759
• Gene Name: histone deacetylase 4
• Gene Aliases: AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA
• Location: Chr.2:239048168-239401647 on Build GRCh38
• Assay Gene Location: Overlaps Intron 1 - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
HDAC4	XM_011512221.1			XP_011510523.1
	AK308791.1

Target Gene Details

• Entrez Gene ID: 101928111
• Gene Name: uncharacterized LOC101928111
• Gene Aliases: -
• Location: Chr.2:239401436-239402364 on Build GRCh38
• Assay Gene Location: Overlaps - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
LOC101928111	NR_135575.1
	BF434856.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1072508	Chr.2:239400205 - 239401506 on Build GRCh38	Deletion	LOC101928111 HDAC4
nsv1118899	Chr.2:239400106 - 239401406 on Build GRCh38	Deletion	HDAC4
dgv7357n54	Chr.2:239400751 - 239401967 on Build GRCh38	Loss	LOC101928111 HDAC4
esv23834	Chr.2:239400174 - 239401561 on Build GRCh38	Loss	LOC101928111 HDAC4
dgv689n67	Chr.2:239392555 - 239406318 on Build GRCh38	Gain	LOC101928111 HDAC4
nsv584793	Chr.2:239400958 - 239401522 on Build GRCh38	Loss	LOC101928111 HDAC4
dgv7355n54	Chr.2:239400274 - 239401967 on Build GRCh38	Gain	LOC101928111 HDAC4
nsv584781	Chr.2:239397060 - 239401967 on Build GRCh38	Gain	LOC101928111 HDAC4
nsv584791	Chr.2:239400622 - 239401522 on Build GRCh38	Gain+Loss	LOC101928111 HDAC4

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

histone modifying enzyme

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast development
chromatin remodeling
transcription, DNA-templated
inflammatory response
nervous system development
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of lamellipodium assembly
negative regulation of myotube differentiation
regulation of cardiac muscle contraction by calcium ion signaling
response to denervation involved in regulation of muscle adaptation
cardiac muscle hypertrophy in response to stress
positive regulation of smooth muscle cell migration
chromatin modification
histone deacetylation
B cell differentiation
positive regulation of protein sumoylation
peptidyl-lysine deacetylation
regulation of gene expression, epigenetic
B cell activation
response to drug
regulation of protein binding
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
negative regulation of osteoblast differentiation
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
regulation of skeletal muscle fiber development
positive regulation of sequence-specific DNA binding transcription factor activity
response to interleukin-1
histone H3 deacetylation
histone H4 deacetylation
cellular response to mechanical stimulus
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
positive regulation of reactive oxygen species biosynthetic process

Function(s)

RNA polymerase III transcription factor binding
core promoter binding
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein binding
transcription factor binding
zinc ion binding
protein kinase binding
potassium ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
activating transcription factor binding
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
repressing transcription factor binding