Mm00393518_cn

• Gene Symbol: Hmgcr
• Assay Reference Genome Location: Chr.13:96658907 on build GRCm38
• Cytoband: 13D1

Target Gene Details

• Entrez Gene ID: 15357
• Gene Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
• Gene Aliases: HMG-CoAR, Red
• Location: Chr.13:96648962-96670936 on Build GRCm38
• Assay Gene Location: Within Exon 10

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
Hmgcr	NM_008255.2	10	1302	NP_032281.2
	AK048784.1
	AK159899.1	9	1191
	BC059873.1			AAH59873.1
	BC085083.1	10	1214	AAH85083.1

More Information

• Set Membership: Intragenic, Exonic

Panther Classification:

Molecular Function -

oxidoreductase, reductase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
ubiquinone metabolic process
steroid metabolic process
cholesterol metabolic process
positive regulation of cell proliferation
isoprenoid biosynthetic process
visual learning
embryo development
negative regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
coenzyme A metabolic process
sterol biosynthetic process
positive regulation of stress-activated MAPK cascade
negative regulation of apoptotic process
negative regulation of MAP kinase activity
negative regulation of vasodilation
positive regulation of skeletal muscle tissue development
positive regulation of smooth muscle cell proliferation
protein tetramerization
oxidation-reduction process
negative regulation of wound healing
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of ERK1 and ERK2 cascade

Function(s)

hydroxymethylglutaryl-CoA reductase (NADPH) activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
hydroxymethylglutaryl-CoA reductase activity
protein homodimerization activity
NADP binding
coenzyme binding
protein phosphatase 2A binding
NADPH binding