Hs00490132_cn

• Gene Symbol: ARNT
• Assay Reference Genome Location: Chr.1:150816343 on build GRCh38
• Cytoband: 1q21.3

Target Gene Details

• Entrez Gene ID: 405
• Gene Name: aryl hydrocarbon receptor nuclear translocator
• Gene Aliases: HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2
• Location: Chr.1:150809705-150876768 on Build GRCh38
• Assay Gene Location: Within Exon 22

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
ARNT	NM_001197325.1	18	2022	NP_001184254.1
	NM_001286035.1	20	2108	NP_001272964.1
	NM_001286036.1	19	2061	NP_001272965.1
	NM_001668.3	19	2067	NP_001659.1
	NM_178427.2	18	2022	NP_848514.1
	XM_005245151.1	19	2009	XP_005245208.1
	XM_005245153.1	19	1994	XP_005245210.1
	XM_005245154.3	20	2037	XP_005245211.1
	XM_005245157.1	18	1898	XP_005245214.1
	XM_011509542.2	19	2070	XP_011507844.1
	XM_011509543.2	20	2065	XP_011507845.1
	XM_011509544.2	19	2034	XP_011507846.1
	XM_011509545.2	18	2025	XP_011507847.1
	XM_011509546.1	18	1785	XP_011507848.1
	XM_011509547.2	18	2025	XP_011507849.1
	XM_017001288.1	20	1912	XP_016856777.1
	XM_017001289.1	20	1897	XP_016856778.1
	XM_017001290.1	19	1866	XP_016856779.1
	XM_017001291.1	19	1868	XP_016856780.1
	XM_017001292.1	19	1802	XP_016856781.1
	XM_017001293.1	18	1759	XP_016856782.1
	XM_017001294.1	18	1898	XP_016856783.1
	XM_017001295.1	18	1883	XP_016856784.1
	XM_017001296.1	17	1862	XP_016856785.1
	AB209877.1	19	1872	BAD93114.1
	AF001307.1			AAC03365.1
	AK290177.1	19	2006
	AK291705.1	18	1864
	AK293027.1	19	2067
	AK304772.1	17	1760
	AK313780.1	19	2008
	AK315812.1	18	1861
	AL834279.1	20	2047	CAD38953.1
	M69238.1	19	1922	AAA51777.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv437169	Chr.1:150765721 - 150844410 on Build GRCh38	Loss	CTSK ARNT CTSS
nsv2788	Chr.1:150782858 - 150828309 on Build GRCh38	Deletion	CTSK ARNT

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

basic helix-loop-helix transcription factor

Gene Ontology Categories:

Process(es)

response to hypoxia
embryonic placenta development
positive regulation of endothelial cell proliferation
transcription, DNA-templated
positive regulation of vascular endothelial growth factor production
cell differentiation
intracellular receptor signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of protein sumoylation
mRNA transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
positive regulation of erythrocyte differentiation
positive regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of hormone biosynthetic process
regulation of transcription from RNA polymerase II promoter in response to hypoxia

Function(s)

transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription coactivator activity
aryl hydrocarbon receptor activity
protein binding
transcription factor binding
aryl hydrocarbon receptor binding
enhancer binding
sequence-specific DNA binding
protein heterodimerization activity