Histology Reagents

Apexbio Technology LLC AMI5/Eosin Y disodium salt 17372-87-1 100mg

AMI5 Eosin Y disodium salt (CAS 17372-87-1) is a small-molecule inhibitor targeting protein methyltransferases including PRMTs and lysine methyltransferases such as Set7 and DOT1L It is designed to competitively bind at the S-adenosylmethionine (SAM) binding site reducing enzymatic methylation activity and influencing gene transcription events AMI5 Eosin Y disodium salt exerts its biological activity primarily through inhibition of protein methyltransferases It inhibits both arginine methyltransferases (including PRMT1 and Hmt1p at low micromolar IC50 values) and lysine-directed enzyme Set7 affecting cellular histone methylation states Based on these pharmacological properties AMI5 Eosin Y disodium salt holds research potential in studying epigenetic roles in transcription regulation and cellular signaling pathways as well as being used experimentally in histological staining