Organometallic Compounds
Medchemexpress LLC 5,8,11-trioxa-2-azatetradecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | 867062-95-1 | 99.8% | 443.49 g/mol | C24H29NO7 | 1 G
Fmoc-NH-PEG3-CH2CH2COOH is an Fmoc-protected PEG3 linker bearing a terminal carboxylic acid, used in research applications as a cleavable linker for antibody-drug conjugates and as a PEG-based linker for PROTAC synthesis.
- Fmoc-protected amine functionality for standard peptide chemistry
- Terminal carboxylic acid for conjugation
- High reported purity (≈99.8%)
- Molecular weight 443.49 g/mol
- Chemical formula C24H29NO7
- Available in small-scale quantities, including 1 G
Medchemexpress LLC NH-bis(PEG3-azide) | 1258939-39-7 | 98.0% | C16H33N7O6 | 50 MG
NH-bis(PEG3-azide) is a PEG-based PROTAC linker used in PROTAC synthesis. It is a click chemistry reagent containing an Azide group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups or strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups.
- Can be used in the synthesis of PROTACs.
- Contains an azide group, facilitating click chemistry reactions.
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups.
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
![Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl] | 1306615-51-9 | 95.0% | 234.25 g/mol | C8H18N4O4 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202344.png-250.jpg)
Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl] | 1306615-51-9 | 95.0% | 234.25 g/mol | C8H18N4O4 | 100 MG
Aminooxy-PEG3-azide is a PEG-based bifunctional linker containing an aminooxy (hydroxylamine) group and an azide group for orthogonal bioconjugation. It enables oxime formation with aldehydes or ketones and azide-alkyne click chemistry, and is supplied as a liquid at high purity for lab-scale synthesis.
- Contains aminooxy and azide functional groups for orthogonal conjugation
- Enables oxime ligation and azide-alkyne click reactions
- Suitable for ADC, PROTAC, and general bioconjugation workflows
- Supplied as a liquid with high laboratory-grade purity
- Available in small-scale pack sizes for research use
Medchemexpress LLC 14-azido-3,6,9,12-tetraoxatetradecan-1-ol | 86770-68-5 | 97.0% | 263.29 g/mol | C10H21N3O5 | 1 G
Azido-PEG5-alcohol is a polyethylene glycol (PEG) linker with a terminal azide and a terminal alcohol, used for bioconjugation and linker installation. The azide group enables copper-catalyzed and strain-promoted azide-alkyne cycloaddition reactions, while the PEG5 spacer improves solubility and flexibility for conjugation workflows.
- Terminal azide enables CuAAC and SPAAC click reactions.
- PEG5 spacer increases solubility and reduces steric hindrance.
- Suitable for use as a non-cleavable linker in conjugation chemistry.
- Colorless to light yellow liquid with high purity.
- Stable under recommended storage conditions for long-term use.
Medchemexpress LLC HO-PEG3- CH2 6-Cl
HO-PEG3-(CH2)6-Cl is a PROTAC linker that can be used to synthesize HaloPROTAC-E (HY-145752)[1]
Medchemexpress LLC Azido-PEG5-acid | 1425973-16-5 | MFCD23726612 | 98.0% | 335.35 g/mol | C13H25N3O7 | 500 MG
Azido-PEG5-acid is an azide-terminated, five-unit polyethylene glycol linker with a terminal carboxylic acid that enables click-chemistry bioconjugation reactions. It is used as a PROTAC and ADC linker and is compatible with copper-catalyzed azide-alkyne cycloaddition and strain-promoted cycloaddition reactions.
- Azide functional group for CuAAC and SPAAC reactions.
- Five-unit PEG spacer provides water solubility and flexibility.
- Terminal carboxylic acid enables amide or ester coupling.
- Typical purity ≥98.0%.
- Suitable for linker synthesis and bioconjugation applications.
Medchemexpress LLC Tos-PEG5-Boc | 581065-94-3 | ≥97.0% | 5 G
Tos-PEG5-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand and a target protein ligand via a linker. It has a molecular weight of 476.58 and the formula C22H36O9S, appearing as a viscous liquid that is colorless to light yellow.
- PEG-based PROTAC linker
- Used for the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- Viscous liquid, colorless to light yellow appearance
Medchemexpress LLC Mal-amido-PEG3-acid | 2055353-75-6 | 372.37 | 50 MG
Mal-amido-PEG3-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system, selectively degrading target proteins by connecting an E3 ubiquitin ligase ligand to a target protein ligand via a linker.
- PEG-based linker
- Used in PROTAC synthesis
- Exploits ubiquitin-proteasome system
- Facilitates selective degradation of target proteins
Medchemexpress LLC PEG3-C4-OBn | 2381196-79-6 | 99.3% | 100 MG
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It can be used in the synthesis of the PROTAC SGK3 degrader-1, which is a potent SKG3 degrader.
- Polyethylene glycol (PEG)-based PROTAC linker
- Used in the synthesis of PROTAC SGK3 degrader-1
- High solubility in DMSO (≥ 100 mg/mL)
- Long-term stability in pure form at -20°C (3 years) and 4°C (2 years)
- Extended stability in solvent at -80°C (6 months) and -20°C (1 month)
Medchemexpress LLC Tos-PEG5-Boc | 581065-94-3 | ≥97.0% | 250 MG
Tos-PEG5-Boc is a PEG-based PROTAC linker designed for the synthesis of PROTACs. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and a ligand for the target protein. It has a molecular weight of 476.58 and a chemical formula of C22H36O9S. Its appearance is a viscous liquid, colorless to light yellow.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
- Viscous liquid, colorless to light yellow appearance
- For research use only
Medchemexpress LLC (S,R,S)-AHPC-C2-PEG3-BCN | 2876198-36-4 | 99.2% | 810.01 g·mol⁻¹ | C42H59N5O9S | 10 MG
(S,R,S)-AHPC-C2-PEG3-BCN (Compound 16b) is a VHL E3 ligase ligand-linker conjugate used as a building block in the synthesis of PROTACs and other conjugates. It features a PEG3 spacer and a bicyclononyne (BCN) functional group to facilitate bioorthogonal conjugation and assembly of bifunctional molecules for targeted protein degradation research.
- VHL E3 ligase ligand for targeted protein degradation applications.
- PEG3 linker provides a flexible spacer for molecular conjugation.
- BCN functional group enables strain-promoted bioorthogonal click conjugation.
- Reported high purity suitable for synthetic chemistry use.
- Intended as a small-molecule building block for PROTAC assembly and conjugation workflows.
Medchemexpress LLC Azido-PEG5-acid | 1425973-16-5 | MFCD23726612 | >98.0% | 335.35 g/mol | C13H25N3O7 | 100 MG
Azido-PEG5-acid is an azide-terminated polyethylene glycol (PEG5) linker designed for click chemistry and bioconjugation. It features a terminal carboxylic acid and an azide functional group that enable copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted azide-alkyne cycloaddition (SPAAC), making it useful for PROTAC construction, ADC linker assembly, and general spacer chemistry.
- Azide-terminated PEG5 spacer for bioconjugation
- Compatible with CuAAC and SPAAC click reactions
- High purity for reliable coupling
- Colorless to light yellow liquid, easy to handle
- Stable under recommended storage conditions
Medchemexpress LLC Pomalidomide-PEG3-C2-NH2 hydrochloride | 2446474-09-3 | 96.6% | 250 MG
Pomalidomide-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a 3-unit PEG linker used in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a Pomalidomide-based cereblon ligand
- Includes a 3-unit PEG linker
- Used in PROTAC technology
- Appears as a light yellow to yellow solid
- Structure consistent by 1H NMR spectrum
- Structure consistent by LCMS
- Purity of 96.6% by LCMS
- For research use only
Medchemexpress LLC Azido-PEG5-acid | 1425973-16-5 | >98.0% | 335.35 | C13H25N3O7 | 10 G
Azido-PEG5-acid is an azide-terminated five-unit polyethylene glycol (PEG5) acid linker used for bioconjugation and linker synthesis. It functions as a click-chemistry reagent capable of undergoing azide-alkyne cycloaddition reactions and is commonly used in PROTAC and antibody-drug conjugate assembly.
- Azide functional group enables copper-catalyzed and strain-promoted click reactions.
- Five-unit PEG spacer provides solubility and flexibility for conjugation.
- High purity supports synthetic and bioconjugation applications.
- Available in multiple pack sizes for scalable workflows.
- Stable under recommended storage conditions to preserve reactivity.