AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. It inhibits the ID2-KDR signaling axis, leading to the down-regulation of downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), while up-regulating the tumor suppressor factor (PTEN). It can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and demonstrates significant cancer-suppressing potency. This compound is used for the study of glioma.
- Potent DNA binding inhibitor 2 (ID2) antagonist
- Inhibits cell migration and invasion of glioma cell lines
- Induces apoptosis
- Demonstrates significant cancer-suppressing potency
- Inhibits ID2-KDR signaling axis
- Down-regulates angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9)
- Up-regulates tumor suppressor factor (PTEN)
- Suitable for the study of glioma